Viral infectious disease

This early-stage trial tests an experimental flu vaccine called FluMos-v2, with or without an adjuvant (ALFQ), in 45 healthy adults aged 18-50. Participants receive two shots four months apart and are followed for 15 months. The goal is to check safety and how well the vaccine tr…

This study is testing two experimental COVID-19 booster vaccines in 80 healthy volunteers aged 40-64. One vaccine includes an extra component called 's3' designed to improve the body's immune response. Participants will receive a single dose of either vaccine or a placebo and be …

This trial is testing an updated version of the BNT162b2 COVID-19 vaccine in healthy adults aged 18 to 64. Participants will receive either the updated COVID-19 vaccine or a Tdap vaccine (for tetanus, diphtheria, and whooping cough) to compare safety and measure spike protein lev…

This early-stage study tests a new vaccine designed to prevent Sudan virus disease, a severe illness similar to Ebola. About 112 healthy adults aged 18-50 will receive either the vaccine or a placebo to check for side effects and measure immune responses. The goal is to see if th…

This study tests several updated mRNA COVID-19 vaccines designed to target new variants of the virus. About 1,100 adults and children with certain risk factors will receive one of the vaccines to see how well it boosts immunity and how safe it is. The goal is to ensure vaccines r…

This Phase 2 trial tests an experimental drug called AHB-137 in 84 adults with chronic hepatitis B who are already on antiviral therapy. The goal is to see if AHB-137 can clear the hepatitis B surface antigen and keep the virus under control, potentially leading to a functional c…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This large Phase 3 trial is testing an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. Participants receive either a single dose of tozorakimab or a placebo, added to standard care. The main goal is to see…

This phase 2 trial tests an experimental drug called AHB-137 in 70 adults with chronic hepatitis B who are already on antiviral pills. The drug is given as a shot under the skin. The goal is to see if it can lower the virus to undetectable levels and allow some people to stop the…

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesiv…

This study tests an oral medication called ibuzatrelvir in adults and teens with COVID-19 who are not hospitalized but have a high risk of becoming severely ill. Participants will receive either the drug or a placebo for 5 days, and researchers will track whether it reduces emerg…

This study tests an experimental antiviral drug called S-337395 in adults with RSV who are at high risk for severe illness. Participants must have symptoms for less than 72 hours and a confirmed RSV infection. The goal is to see if the drug can lower the amount of virus in the bo…

This early-phase trial tests a treatment called LB-DTK-MV, which uses immune cells from a healthy donor to fight three viruses (CMV, BKV, and EBV) that have become resistant to standard antiviral drugs. The study includes 27 adults who have had a stem cell transplant or certain c…

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether reducing anti-rejection drugs, with or without an extra treatment called IVIG, can better control BK virus in kidney transplant patients. BK virus can damage the new kidney and lead to transplant failure. About 280 adults and children who have a kidney or…

This study tests whether specially grown immune cells (BK-specific cytotoxic T-cells) from a related donor can safely lower BK virus levels in children, teens, and young adults. Participants have BK infections that did not get better with standard treatment, often after a stem ce…

This early-stage trial tests whether specially grown immune cells (norovirus-specific T-cells) can safely treat chronic norovirus infections in people with weakened immune systems, such as those who had a stem cell or organ transplant. The study will enroll 48 participants and gi…

This study is testing whether a blood test called Karius Spectrum can help doctors find infections faster in adults with weakened immune systems (e.g., organ transplant recipients, cancer patients). The test looks for DNA from bacteria, fungi, viruses, and parasites in the blood.…

This study is testing a new diagnostic tool that helps doctors quickly tell if a respiratory infection is caused by bacteria or a virus. The goal is to see if using this test leads to better treatment decisions, fewer unnecessary antibiotics, and lower healthcare costs. About 100…

This study looks at how well a live shingles vaccine prevents shingles over 6 years in adults aged 40 and older. It follows about 24,740 people who were in an earlier vaccine trial, comparing those who got the vaccine first to those who got it later. Researchers will track new sh…

This study tests whether portable HEPA air cleaners placed in elementary school classrooms can lower the amount of viruses in the air and reduce infections among students, teachers, and their families. About 200 participants from grades K-5 will be randomly assigned to classrooms…

This study tests whether giving the COVID-19 vaccine (Comirnaty) to children starting at 6 months old can lower their chance of developing type 1 diabetes. The trial will include 2,252 children who have a high genetic risk for the disease. Half will get the vaccine, half a placeb…

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or the flu. Researchers want to find out if these people have hidden immune system or genetic problems that make them more vulnerable. Up to 600 participa…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study follows 400 people with mitochondrial disease and their household members to learn how infections affect them. Researchers will analyze blood samples and health records to find immune patterns linked to severe illness. The goal is to improve care and identify potential…

This study aims to understand how the human body responds to dengue virus infection, including in people who have had dengue before. Healthy volunteers aged 18 to 50 receive a single injection of a weakened dengue virus and are closely monitored for six months. Researchers measur…

This study looks at how viruses change the environment around tumors in people with lymphoma, lung cancer, or anal cancer. Researchers will analyze blood and tumor samples from 254 patients to understand why some cancers resist treatment. The goal is to find new ways to make anti…

This study aims to develop a predictive model for mortality in critically ill patients who carry multidrug-resistant gram-negative bacteria (MDR-GNB). Researchers will follow about 1,500 adults in intensive care units (ICUs) who are colonized with these bacteria, tracking their i…

This study aims to find genetic mutations that cause chronic active Epstein-Barr virus (CAEBV), a rare and serious disease mainly affecting children and young adults. Researchers will analyze blood and tissue samples from up to 50 patients and 150 relatives, plus anonymous donor …

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This study is creating a registry of 600 children under 18 with meningitis treated at hospitals across Brazil. Researchers will collect data during and after hospitalization to see how well current treatments work and what long-term problems, like hearing loss, occur. The goal is…

This study looks at whether it is safe to stop antibiotics early in elderly patients (65+) hospitalized for a viral lung infection. Many patients get antibiotics even when they have a virus, which can cause side effects and lead to antibiotic resistance. Researchers will compare …

This study looks at how two over-the-counter mouthwashes (Listerine and Lumineux Oral Essentials) affect bacteria and three common viruses in the mouth and gut. Two hundred healthy adults aged 18-25 will rinse twice daily with one of the mouthwashes or water for about six months.…

This study looks at whether people bitten by monkeys can catch certain viruses, like STLV-1 and SFV. Researchers will collect blood and saliva samples from 80 adults who have had a recent monkey bite. The goal is to better understand the risk of virus transmission from these bite…

This study looks at how breast milk influences viruses like HTLV-1, Zika, and dengue. Researchers will mix milk samples with these viruses in the lab to see if the milk changes how well the viruses infect cells. The goal is to understand if breastfeeding can spread or block these…

This study follows 1,088 newborns in Colombia and Panama until age 5 to learn how often respiratory infections happen, which viruses or bacteria cause them, and why some children get sicker than others. Families report symptoms twice a week and provide nasal and blood samples dur…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…