Pancreatitis

This study investigates whether giving phosphate through an IV can reduce the severity of acute pancreatitis in adults. Researchers want to know if low phosphate levels make the disease worse and if replenishing it helps. Participants receive either standard care or IV phosphate …

This trial tests whether giving fluids based on real-time changes in stroke volume—a measure of how much blood the heart pumps—can improve outcomes in people with moderate to severe acute pancreatitis. Standard care uses a fixed weight-based amount, which can sometimes lead to fl…

This study tests a single injection of a drug called RABI-767, given through a scope into the area around the pancreas, for people with predicted severe acute pancreatitis. About 36 participants will be randomly assigned to get the drug plus standard care or standard care alone. …

This study tests two diabetes medications, pioglitazone and empagliflozin, to see which one better controls blood sugar in people whose diabetes is caused by chronic or recurrent acute pancreatitis. About 40 adults aged 18-80 with this type of diabetes will take one of the drugs,…

This study tests a drug called pirfenidone, currently used for lung disease, to see if it can safely reduce repeat attacks of pancreatitis. About 60 adults who have had two or more pancreatitis episodes will receive either the drug or a placebo. The goal is to lower the number an…

This trial tests whether adding a specific probiotic (Bacillus subtilis and Enterococcus faecium) to standard lipid-lowering therapy can reduce triglyceride levels and inflammation in people hospitalized with pancreatitis caused by very high triglycerides. About 180 adults with m…

This study tests whether a single infusion of infliximab, a drug used for arthritis and Crohn's disease, can reduce inflammation in adults with acute pancreatitis. About 290 participants will receive either a low dose, a high dose, or a placebo. The main goal is to see if inflixi…

This study tests a freezing device called a cryoprobe to remove dead tissue from the pancreas in people with a serious complication of acute pancreatitis. Instead of using standard tools like forceps or snares, the cryoprobe freezes the dead tissue so it can be pulled out more ea…

This study tests a drug called CM4620 in children and young adults who develop pancreatitis (inflammation of the pancreas) from a chemotherapy drug called asparaginase. The goal is to see if CM4620 is safe and can prevent severe complications like pancreatic cysts or tissue death…

This study tests a device called RELiZORB that adds digestive enzymes directly to liquid food given through a feeding tube. It is for people who have trouble digesting food after pancreatitis. The goal is to see if it improves symptoms and quality of life. About 60 adults will ta…

This phase 3 trial tests whether taking pancreatic enzyme capsules can help people who have lost significant weight after a severe bout of pancreatitis. The study will enroll 140 adults with more than 50% pancreatic damage and at least 5% weight loss. Participants will receive ei…

This study tests a device called Efferon LPS that filters toxins and inflammatory substances from the blood. It is being given to 150 people with severe acute pancreatitis within 24 hours of ICU admission. The goal is to see if it reduces organ failure and improves outcomes compa…

This study tests whether a short course of the steroid hydrocortisone can reduce inflammation and improve outcomes for people with severe pancreatitis. Researchers will give the drug or a placebo to 86 ICU patients and track their organ failure scores and hospital stay length. Th…

This early-stage trial tests a single infusion of CS-121, a gene editing therapy, in 15 adults with familial chylomicronemia syndrome (FCS), a rare condition causing extremely high blood fat levels. The therapy targets the APOC3 gene to lower triglycerides and reduce disease burd…

This early-stage trial tests a new gene-editing treatment called CS-121 in 15 children and teens (ages 4-18) with a rare condition causing extremely high triglycerides. The therapy uses lipid nanoparticles to deliver a base editor that targets the APOC3 gene in the liver. The mai…

This study is testing whether taking pancreatic enzyme supplements (Creon) can improve blood sugar control and digestive function in people with chronic pancreatitis who have trouble digesting food. Researchers will monitor 80 participants over time to see how their glucose level…

This trial tests whether giving three treatments together—two medicines and a surgical patch—can lower the risk of major complications after Whipple surgery for pancreatic cancer and other tumors. The study includes 400 high-risk patients with a small pancreatic duct. If successf…

This trial looks at whether removing the gallbladder early (during the same hospital stay) or waiting 4 weeks after recovery is better for people with severe pancreatitis caused by gallstones. About 134 adults will be randomly assigned to one of the two timing options. The main g…

This study tests whether transplanting healthy gut bacteria (FMT) can reduce infections in people with moderate to severe acute pancreatitis. 80 participants will receive either FMT or a placebo through a feeding tube for five days. The goal is to see if FMT lowers the risk of se…

This study tests a new blood test (Malabsorption Blood Test, or MBT) to find mild-to-moderate pancreatic insufficiency in people with chronic or recurrent acute pancreatitis. A small group of participants who respond to pancreatic enzyme replacement therapy (PERT) will then be ra…

This study tests an artificial intelligence (AI) system that analyzes contrast-enhanced CT scans to help diagnose and manage pancreatic diseases. The AI will classify patients into three groups: needing immediate treatment, close monitoring, or routine follow-up. Researchers will…

This trial tests whether rinsing the bile-duct opening with ice-cold water, on top of standard anti-inflammatory medication, can lower the chance of pancreatitis after an ERCP procedure. About 462 adults who need an ERCP will receive either the usual NSAID pill alone or the NSAID…

This trial tests whether giving a rapid, short course of IV fluids (Lactated Ringer's) along with a rectal anti-inflammatory drug (indomethacin) can prevent pancreatitis, a common and serious complication after ERCP, a procedure used to diagnose and treat bile duct issues. The st…

This study compares two rectal non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and diclofenac, to see which one better prevents pancreatitis after an ERCP procedure. About 4050 adults aged 18-90 with an intact papilla will be randomly assigned to receive one of the d…

This study tests whether rinsing the bile duct opening with cold water at the end of an ERCP procedure, on top of standard medication, can reduce the risk of pancreatitis—the most common major complication after ERCP. About 950 adults with a natural papilla (the bile duct opening…

This study tests whether fecal microbiota transplantation (FMT) — transferring gut bacteria from healthy donors — can prevent infections in people with moderately severe or severe acute pancreatitis. About 150 adults will receive either FMT liquid or a placebo through a feeding t…

This study tests whether giving extra IV fluids along with a standard anti-inflammatory suppository can better prevent pancreatitis after a procedure to break up pancreatic stones. About 1250 adults with chronic pancreatitis will be randomly assigned to receive either the combina…

This study tests if spraying nitroglycerin directly into the bile duct during an ERCP procedure can prevent pancreatitis, a common and serious complication. About 440 adults who need ERCP to remove bile duct stones will take part. The goal is to see if this simple, local treatmen…

This pilot study tests whether simvastatin, a common cholesterol medication, can improve quality of life in adults with recurrent acute or chronic pancreatitis. Researchers will enroll 90 participants to check if the drug is feasible and acceptable. The goal is to see if it helps…

This study tests a mobile app that gives personalized exercise coaching and feedback on blood sugar, sleep, and mood to help middle-aged adults with type 1 diabetes exercise more. Participants get a free Garmin smartwatch and program membership. The goal is to see if the app help…

This study tests an internet-delivered pain self-management program for adults with chronic pancreatitis who suffer from severe abdominal pain. The program uses psychological techniques to help reduce pain's impact on daily life and improve quality of life. Researchers aim to enr…

This study is testing whether people with recurrent acute or chronic pancreatitis can safely drink a soy tomato juice beverage every day. Researchers will check for side effects, measure inflammation in the blood, and ask participants how they feel. The goal is to see if the drin…

This study tracks how well a nerve block procedure called celiac plexus neurolysis (CPN) helps manage pain in people with chronic pancreatitis. Researchers will follow 35 patients for 24 weeks, recording their pain scores and pain medication use. The goal is to see if the procedu…

This pilot study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain the brain's pain response. Forty adults with chronic pancreatitis and persistent abdominal pain will receive 5-10 daily sessions. Researchers will measure pai…

This study is for people with pancreatic cysts or other pancreas issues. Researchers will collect blood, tissue, and scan data from over 1,100 participants to create a large database. The goal is to develop noninvasive tools that predict which cysts may become cancerous, helping …

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

This study looks at whether a special pain test called Pancreatic Quantitative Sensory Testing (P-QST) can predict how well people with chronic pancreatitis will respond to treatments like endoscopy or surgery. About 150 adults with chronic pancreatitis and ongoing pain will take…

This study gathers blood, saliva, urine, and stool from up to 1,600 children with recurrent or chronic pancreatitis. Researchers look for genetic markers that might increase the risk of pancreatic cancer later in life. No treatment is given—the goal is simply to learn more about …

Researchers are studying whether the mix of bacteria in the gut relates to complications of gallstone disease, such as pancreatitis and acute cholecystitis. Adults with confirmed gallstones at East Kent hospitals provide stool samples at several points, including before and after…

Researchers at IRCCS San Raffaele are creating a registry of images and videos from endoscopic ultrasound procedures performed to investigate pancreatic diseases. The study will gather data from about 12,000 patients with conditions like pancreatitis, pancreatic cancer, and neuro…

Researchers are creating a biobank of biological samples and clinical data from 2000 adults with various pancreatic conditions, including pancreatitis and pancreatic cancer. The goal is to investigate how genetic predisposition and environmental exposures interact to trigger thes…

This study aims to find new blood-based markers that can predict or diagnose infected pancreatic necrosis (IPN) in people with severe pancreatitis. About 20% of acute pancreatitis cases develop tissue death (necrosis), and when that tissue gets infected, the risk of death rises t…

This study follows 150 patients who have had part of their pancreas removed. Researchers will measure blood levels of amylase and lipase before, during, and after surgery to see if high levels can predict serious complications like pancreatitis. The goal is to improve how doctors…

This study aims to create a simple, minimally invasive test to find pancreatic cancer at an early stage and track how well treatment is working. Researchers will study 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to identify biological markers…

This study is a registry that will follow 1,000 people who receive standard endoscopic treatment for fluid collections caused by pancreatitis. The goal is to see how well the procedure works and what outcomes patients experience. No new treatment is being tested—this is about gat…

This study is testing a new ultrasound method that uses tiny, safe bubbles to measure blood flow in the pancreas. The goal is to see if changes in blood flow can help detect type 1 diabetes early, before symptoms appear. Researchers will compare 50 healthy adults and people recen…

This study explores whether monitoring bowel sounds can help predict which patients with acute pancreatitis will develop a severe form of the disease. Researchers will enroll 352 adults across three hospitals and track their bowel sounds for at least 48 hours. The goal is to see …

The PREDICT study is creating a registry and biospecimen bank for people with pancreatic disease or at high risk for pancreatic cancer. Researchers will collect blood, tissue, urine, and other samples from 1,000 participants to study the causes and biology of the disease. This is…

This study is a registry that gathers information from up to 500 people in Russia who have extremely high triglyceride levels (a type of fat in the blood). The goal is to learn more about their health, genetics, and current treatments. No new drugs or procedures are tested—just o…

This study collects blood, tissue, and health information from 20,000 people with pancreas diseases like pancreatic cancer, pancreatitis, or cysts. The goal is to create a large database and sample bank that researchers can use to better understand these conditions and develop be…

This study will review the medical records of 10 patients who developed acute pancreatitis within two weeks after a procedure to remove blood clots (percutaneous mechanical thrombectomy). The goal is to find out how often this complication happens, what patient or procedure facto…

This study looks at whether a continuous glucose monitor (CGM) can help predict who will develop diabetes after an episode of acute pancreatitis. Researchers will follow 800 people for up to 36 months, using the CGM device to track blood sugar levels. The goal is to see if CGM ca…

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study compares two imaging techniques—laparoscopic ultrasound and a special dye called indocyanine green—to help surgeons see important bile duct structures during difficult gallbladder removal surgery. About 62 adults with conditions like acute cholecystitis, prior abdomina…

This study looks at whether feeding through a tube into the small intestine is better than eating by mouth after a procedure to drain a pancreatic cyst caused by severe pancreatitis. About 50 adults with this condition will be randomly assigned to one of the two feeding methods. …

This study looks at 500 adults with acute pancreatitis to find out how often blood clots form in the veins around the pancreas (splanchnic veins). Researchers will also check if these clots are linked to more severe pancreatitis. Participants will have imaging scans to detect clo…

This study looks at blood markers and how well transplanted insulin-making cells (islets) work in people with chronic pancreatitis who have their pancreas removed and get their own islets back. Researchers will follow 100 adults for at least two years to understand graft function…

This study follows 800 people who recently had acute pancreatitis to see who develops diabetes and why. Participants are observed for 36 months with tests and surveys. No new treatments are tested; the goal is to learn how and why diabetes occurs after pancreatitis.

This study is following over 2,300 people across the US to better understand chronic pancreatitis, a painful long-term condition of the pancreas. Researchers will track participants' symptoms and disease changes over time to identify what causes the disease and how it progresses.…

This study tracks 300 adults in Tehran who are getting a pancreas biopsy (EUS-guided FNB) to see how often pancreatitis occurs afterward. Researchers will measure enzyme levels 24 hours later and check for pain. The goal is to find out which factors—like age, gender, or biopsy lo…

This study follows 250 patients who are having surgery to remove part of their pancreas due to cancer, pancreatitis, or cysts. Researchers will track changes in quality of life, symptoms, and emotional well-being for up to two years after surgery. The goal is to understand how th…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …