Orthocoronavirinae infectious disease

This trial tests a new vaccine called LV-SMENP, designed to teach the body's immune cells to recognize and attack the COVID-19 virus. The vaccine uses a harmless virus to deliver pieces of the coronavirus into dendritic cells, which then activate T cells to fight infection. The s…

This Phase 1 trial tests a new type of COVID-19 vaccine made from artificial antigen presenting cells (aAPC). The vaccine is designed to teach the body's T cells to recognize and attack the SARS-CoV-2 virus. The study includes healthy volunteers and people with mild COVID-19, and…

This Phase 3 study tested two Sanofi COVID-19 vaccines (one targeting the original virus, another targeting two variants) in about 24,000 adults. The goal was to see if they could prevent COVID-19 safely. The trial was terminated early, so final results are limited, but the data …

This study looked at whether the mRNA-1273.214 COVID-19 vaccine is safe and works in infants as young as 12 weeks to under 6 months old. It was a small, early-stage trial that was stopped before completion. The main goal was to check for side effects like fever, fussiness, and in…

This study tested Sanofi's experimental mRNA vaccine against COVID-19 in 182 healthy adults aged 18 and older. The main goals were to check safety and measure the body's immune response. The trial was terminated early, so full results are not available.

This study tested whether using a baby shampoo nasal wash and Listerine mouthwash for 4 days could lower the amount of COVID-19 virus in the nose and throat of recently infected adults aged 18-65. Participants were randomly assigned to different wash combinations, including plain…

This small Phase 2 trial tested an experimental drug called Auxora in 10 patients with critical COVID-19 pneumonia who were on ventilators. The goal was to see how the drug affected immune cells in the lungs and to check its safety. The study was terminated early, so results are …

This phase II trial tests whether a single, ultra-low dose of radiation to both lungs can reduce the dangerous inflammation caused by COVID-19 pneumonia in critically ill patients who need a ventilator. The treatment, a one-time 80 cGy X-ray session, aims to calm the immune syste…

This trial is investigating how the COVID-19 treatment Paxlovid (nirmatrelvir/ritonavir) is absorbed and eliminated by the body, and how well it is tolerated, in pregnant women with mild-to-moderate COVID-19. The study will compare these results to those from non-pregnant women w…

This trial is testing whether adding flunotinib, an experimental drug that targets inflammation, to standard antiviral treatment can help people hospitalized with severe COVID-19. The study includes adults with confirmed COVID-19 who are getting worse despite standard care. The m…

This study tests whether a single infusion of hyperimmune immunoglobulin (hIVIG) — concentrated antibodies from recovered COVID-19 patients — can help adults at high risk (age 55+ or with weakened immune systems) who have early COVID-19. Participants receive either the antibody i…

This trial is testing an organic compound called NP-101 in adults with mild-to-moderate COVID-19 who are at high risk of severe illness. The study aims to find the safest and most effective dose, and to see whether NP-101 can help patients recover faster and reduce the amount of …

This trial tests whether an experimental drug called BIO101 can prevent severe breathing problems in hospitalized adults with COVID-19 pneumonia. Participants receive either BIO101 or a placebo for 28 days, and researchers track who develops respiratory failure, needs high-flow o…

This trial tests whether an experimental stem cell therapy called MultiStem can help people with moderate to severe acute respiratory distress syndrome (ARDS) caused by infections like COVID-19. ARDS is a serious lung condition that often requires a breathing tube and ventilator.…

This study tested the drug baricitinib in children aged 1 to 18 who were hospitalized with COVID-19 and needed extra oxygen. The goal was to see if the drug was safe and how it worked in kids. Only 6 children took part before the study was stopped early.

This early-stage trial is testing whether genetically modified T-cells can safely control viral infections in cancer patients with weakened immune systems. The T-cells are designed to target specific viruses like CMV, BK virus, or COVID-19. The study involves 30 participants and …

This phase 3 trial tests whether an inhaled combination of budesonide (a corticosteroid) and formoterol (a bronchodilator) can prevent acute respiratory failure in hospitalized adults with pneumonia and low blood oxygen levels. Participants receive either the active treatment or …

This study tests whether a specific type of exercise, called eccentric exercise, can help people recover muscle strength and walking ability after a severe COVID-19 infection. Participants, aged 18 to 80, will be randomly assigned to either eccentric or standard concentric exerci…

This phase 2 trial tests whether a combination of atovaquone (an anti-malarial) and azithromycin (an antibiotic) can clear the COVID-19 virus in infected adults. The study enrolls people at high risk for complications, such as those with moderate to severe illness. Participants r…

This early-phase trial tested a new therapy called CYNK-001, which uses natural killer cells from the placenta to fight COVID-19. It enrolled only 7 adults with moderate COVID-19. The study was terminated early, so we have limited information on safety and effectiveness.

This study tested a drug called deupirfenidone (LYT-100) in 185 adults who had breathing problems after a serious COVID-19 infection. Participants took either the drug or a placebo for several weeks to see if it improved their ability to walk. The trial was stopped early, so the …

This study tests whether an additional dose of a COVID-19 vaccine can improve immune protection in adults and children with autoimmune diseases like rheumatoid arthritis, lupus, multiple sclerosis, and others who are taking immunosuppressive medications. Participants who had a we…

This study tested an experimental drug called APX-115 in hospitalized patients with mild to moderate COVID-19. The goal was to see if it was safe and could help people recover faster. However, the trial was stopped early and only 16 people took part, so we don't have enough infor…

This study tested whether a low dose of tocilizumab, a drug used for arthritis, could help hospitalized COVID-19 patients with lung inflammation who were not on a breathing machine. The goal was to see if it sped up recovery and reduced deaths. The trial was stopped early, but re…

This study tested a drug called INB03 in 79 high-risk COVID-19 patients to see if it could prevent their breathing from getting worse. Participants received two weekly injections of either INB03 or a placebo. The trial was terminated early, so we do not have clear results on whet…

This study tested whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help hospitalized patients with moderate to severe COVID-19. The plasma contains antibodies that might fight the virus. The trial planned to enroll many patients but w…

This study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…

This study tested whether imatinib, a drug used for certain cancers, could help hospitalized adults with COVID-19. Participants received either imatinib or a placebo alongside standard care. The trial was stopped early and only included 21 people, so no firm conclusions can be dr…

This study tested whether breathing in nitric oxide gas could keep mild-to-moderate COVID-19 from becoming severe. Researchers enrolled 62 hospitalized adults who were breathing on their own. The goal was to see if the gas reduced the need for a breathing tube. The trial was stop…

This phase 2 trial tested whether adding aprepitant, a drug usually used for nausea, to standard care could help hospitalized COVID-19 patients recover faster. The study planned to enroll adults recently admitted to the hospital with COVID-19 and signs of lung involvement. Howeve…

This study tested whether adding reparixin to standard care could prevent death or the need for a breathing machine in 414 hospitalized adults with COVID-19 or other pneumonia. The trial was stopped early. Researchers compared reparixin to a placebo to see if it reduced severe ou…

This study tested the drug tocilizumab (Actemra) in hospitalized adults with severe COVID-19 and signs of inflammation. Participants received either the drug or a placebo, with the goal of improving clinical status by day 28. The trial was terminated early after enrolling only 20…

This study tested whether hydroxychloroquine (a malaria drug) could help hospitalized COVID-19 patients recover faster. It planned to enroll 350 people but was stopped early with just 17 participants. Because it ended so early, we cannot say whether the drug works or is safe for …

This study tested a single dose of ensovibep, a lab-made protein, in 407 adults with mild COVID-19 symptoms. The goal was to see if it could lower the amount of virus in the body and reduce hospitalizations. The trial was stopped early, so we don't have complete answers on how we…

This study tested whether a medicine called emetine could help adults aged 30 and older recover from COVID-19. Participants took emetine or a placebo daily for 10 days. The trial was stopped early after only 4 people enrolled, so we don't have enough information to know if emetin…

This early-phase study aimed to see if combining two immune-stimulating drugs (rintatolimod and interferon alpha-2b) could help cancer patients fight off COVID-19. Only 4 people took part before the study was stopped early. The main goals were to check safety and measure how the …

This Phase 2 trial tested the drug silmitasertib (CX-4945) plus standard care in adults with pneumonia caused by COVID-19 or influenza. The goal was to see if the drug could reduce the need for hospitalization or prevent death. The study planned to enroll 120 people but was termi…

This study tested an experimental drug called ABX464 in 509 high-risk COVID-19 patients aged 65 and older, or those 18+ with risk factors like obesity or diabetes. The goal was to see if the drug could reduce inflammation and prevent the need for high-flow oxygen or a breathing m…

This study tested an oral antiviral drug called ensitrelvir in hospitalized COVID-19 patients. The goal was to see if it could help them recover faster. However, the trial was stopped early, so we have limited information on whether it works.

This study tested an experimental drug called LAU-7b in adults hospitalized with COVID-19 who had health issues like diabetes that put them at higher risk for complications. The goal was to see if LAU-7b could prevent respiratory failure or the need for a breathing machine. The t…

This early-stage study tested a new antibody drug (REGN14256) alone or with imdevimab in 25 adults with mild COVID-19 and no risk factors for severe illness. The goal was to check safety and whether the drug could lower virus levels. However, the trial was terminated early, so we…

This study tested a lab-made antibody called SCTA01 in adults hospitalized with severe COVID-19. The goal was to see if it could help them recover faster. The trial was stopped early, so we don't have clear results on its effectiveness.

This study tested a single injection of two lab-made antibodies (casirivimab and imdevimab) in children under 12 who are at high risk for severe COVID-19. The goal was to see how the drug behaves in the body, if it is safe, and if it triggers an immune response. Only 7 children t…

This study tested a single dose of casirivimab+imdevimab (REGN-COV2) in children hospitalized with COVID-19. The goal was to see how the drug behaves in the body and whether it is safe. However, the study was terminated early and only enrolled 2 participants, so we have very litt…

This study tested whether infusions of stem cells from donated fat tissue could help people with COVID-19. The trial planned to enroll 48 adults and compare four doses of stem cells against a placebo. The goal was to see if the treatment could reduce inflammation and improve oxyg…

This early-phase study tested whether hydroxychloroquine, a drug used for malaria and autoimmune diseases, could reduce the amount of virus in adults with mild COVID-19 not needing oxygen. Only 8 people took part before the trial was stopped early. The study was too small to draw…

This study tested a drug called fosmanogepix in 21 adults with invasive mold infections (like Aspergillus or rare molds) who had few other options. The trial was stopped early, so we have limited data on how well it works or its safety.

This phase 3 trial tested whether a dose of the Janssen COVID-19 vaccine could boost immunity in kidney transplant recipients who had already received two or three mRNA vaccine doses. The study enrolled 468 participants and also looked at reducing immunosuppression medication. Ho…

This study tested a nasal spray called AD17002 in 180 adults with mild to moderate COVID-19. Participants received either a low dose, high dose, or placebo spray alongside standard care. The goal was to see if the spray speeds up recovery and improves symptoms. However, the trial…

This study tested whether a single infusion of stem cells from umbilical cord tissue (ProTrans®) could help hospitalized adults with severe COVID-19 avoid ventilators or death. The trial was stopped early after enrolling only 19 people, so we cannot draw firm conclusions. Both th…

This study looked at using a fast, point-of-care COVID-19 test to help doctors quickly decide how to treat patients with serious heart or breathing problems. It involved 66 adults who already tested positive for COVID-19. The goal was to find the best way to collect samples (nose…

This study explored whether analyzing sweat from fingerprints using a special camera could quickly detect COVID-19. Researchers enrolled 66 adults who had tested positive or negative for COVID-19 within the past week. Participants provided a fingerprint sweat sample and a blood s…

This study tested whether a one-minute sit-to-stand test could help emergency doctors decide if COVID-19 patients need hospital care. The test measures oxygen levels and breathing effort during repeated standing from a chair. The trial aimed to reduce unnecessary hospital stays b…

This study tested whether breathing in nitric oxide gas could prevent healthcare workers from catching COVID-19. The plan was to enroll 470 workers, but the trial was stopped early with only 24 participants. Workers in the treatment group inhaled the gas at the start and end of e…

This study tested whether a combination of antibodies (casirivimab+imdevimab) could prevent COVID-19 in people with weakened immune systems, such as transplant recipients or cancer patients. Participants received either the antibodies or a placebo as a shot under the skin. The tr…

This study tested whether a nitric oxide nasal spray could prevent COVID-19 in people at risk of exposure. About 1,400 adults used the spray or a placebo for 28 days. The trial was terminated early, so final results are not available.

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

This study tested whether a daily pill used for HIV (TAF/FTC) could prevent COVID-19 in healthcare workers at high risk of exposure. Over 1,300 workers were randomly assigned to get the drug or a placebo for 12 weeks. The trial was stopped early, so it's unclear if the drug had a…

This trial tests whether a structured cardiac rehabilitation program can improve exercise capacity and heart rate response in people with Long COVID. Participants have persistent symptoms and reduced exercise tolerance after a confirmed COVID-19 infection. The program includes pe…

This study tested a smartphone app that teaches mindfulness meditation to help Black and Latino adults with anxiety during the COVID-19 pandemic. About 400 participants were assigned to one of two mindfulness programs or a waitlist. The trial was terminated early, so we don't hav…

This study tested whether rinsing the nose and gargling with salt water could help people with suspected or confirmed COVID-19 feel better faster. Only 16 adults in the UK took part before the study was stopped early. The goal was to see if this simple home remedy could reduce ho…

This small pilot study tested whether a traditional Chinese medicine called Xuanfei Baidu granules is safe and acceptable for people with mild to moderate COVID-19. Only 10 adults were enrolled before the study was stopped early. The main goal was to see how many people would agr…

This study looked at whether using the Calm meditation app could help medical residents and fellows at Banner University Medical Center Phoenix feel less stressed, anxious, or burned out during the COVID-19 pandemic. Only 7 people signed up, and the study was stopped early, so we…

This study looked at whether a supervised exercise and pulmonary rehabilitation program could help people with Long COVID feel better and move more easily. Researchers measured changes in aerobic capacity, fatigue, and quality of life in 21 adults who had COVID at least 12 weeks …

This study looks at anonymous health records from California and Louisiana to see if the Pfizer-BioNTech COVID-19 vaccine helps prevent post-COVID conditions (long COVID). Researchers will also track who gets vaccinated. The study includes adults with a COVID-19 diagnosis between…

This study aimed to see if COVID-19 vaccines cause more side effects in cancer patients receiving immunotherapy. Researchers planned to track 125 patients from several hospitals in France, recording any local or systemic side effects. The study was terminated early, so the full r…

This study collected blood, urine, stool, and respiratory samples from 615 COVID-19 patients and caregivers at Bordeaux University Hospital. The goal was to build a biobank for research on the virus and disease. The study was terminated early, but the samples may still help scien…

This study looked for hidden brain damage in 38 hospitalized COVID-19 patients. Instead of using standard MRI scans, researchers used electrical tests to check how well the brainstem was working. The goal was to find subtle nervous system problems that might not show up on regula…

This study tested a web-based guide to help people have conversations about COVID-19. It enrolled 30 adults who spoke English or Spanish. The guide offered virtual conversations tailored to different concerns. The study was terminated early, so results are limited.

This study tested a software platform called ICU Cockpit that collects and displays vital signs and other data from brain-injury patients in the intensive care unit. The goal was to help doctors make faster, better decisions and to predict complications like strokes or unstable c…

This study used artificial intelligence to analyze electronic health records from 100,000 COVID-19 patients across multiple hospitals. The goal was to identify factors that predict whether a patient would be hospitalized, need ICU care, or die. The study was terminated early, so …

This study aimed to check how accurate several COVID-19 antibody tests are. Researchers used blood samples from 101 adults, including some taken before the pandemic and some from people with other infections. The goal was to see which tests best detect past COVID-19 infection.

This study tested a special vest that tracks health data like heart rate and breathing in people hospitalized with COVID-19. The goal was to see if the vest could help doctors spot worsening symptoms early. Only 15 adults took part before the study ended early.

This study looked at how immunosuppressive medications used for rheumatoid arthritis and spondyloarthritis affect the body's ability to fight COVID-19. Researchers measured viral load and immune responses in 150 patients and their infected family members. The goal was to understa…

This pilot study tested a new brain PET-MR scanner to see if it can capture clear images of brain metabolism and blood flow in people who had COVID-19 and those who did not. Only 3 participants were enrolled before the study ended early. The goal was to develop an imaging protoco…

This study looked at whether virtual coaching helps rural pharmacists better counsel patients who are hesitant about COVID-19 vaccines. Sixteen pharmacies took part, first receiving standard training and then adding one-on-one video coaching. The main goal was to see if coaching …

This study aimed to understand how COVID-19 affects people with cancer, especially those receiving treatment. Researchers planned to measure how many cancer patients had COVID-19 without symptoms and how their immune systems responded. The study was terminated early, so results a…

This study followed 80 adults who recovered from COVID-19 to check for heart problems. Participants had heart exams and blood tests one month and one year after recovery. The goal was to understand how often and what kind of heart issues occur after COVID-19, so doctors can bette…

This study aimed to measure how well the 2024-2025 Pfizer COVID-19 vaccine prevents symptomatic infection in people visiting CVS MinuteClinics. Researchers planned to compare vaccinated and unvaccinated patients across age groups and variant periods. However, the study was termin…

This study tested a special band called AirGo to monitor breathing patterns in hospitalized COVID-19 patients with respiratory failure. The goal was to see if the band could detect early signs of worsening breathing, helping doctors decide when to use a breathing tube. The study …

This early-phase study tested the safety and tolerability of an experimental drug called iCP-NI in 24 healthy adults. Participants received either the drug or a placebo by intravenous infusion. The trial was terminated, so no conclusions about effectiveness can be drawn.

This study looked at how well the COVID-19 vaccine triggers an immune response in people with autoimmune or inflammatory diseases who take immunosuppressants or biologics. Researchers took blood samples before vaccination and at several points after to measure antibodies and T-ce…

This study aimed to collect eye scans from people who had COVID-19 to see if the virus caused damage to the retina, the light-sensitive tissue at the back of the eye. Researchers planned to compare severe and mild COVID-19 cases, but the study was stopped early and only enrolled …