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Could a single infusion of COVID-Fighting antibodies keep High-Risk patients out of the hospital?

NCT ID NCT04910269

First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 33 times

Summary

This study tests whether a single infusion of hyperimmune immunoglobulin (hIVIG) — concentrated antibodies from recovered COVID-19 patients — can help adults at high risk (age 55+ or with weakened immune systems) who have early COVID-19. Participants receive either the antibody infusion or a placebo (salt water) and are followed for 28 days to see if they recover faster or avoid hospitalization. The trial was suspended, so results are not yet available.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 3rd Dept of Medicine, Medical School

    Athens, Attica, 11527, Greece

  • 4th Department of Internal Medicine

    Athens, Attica, 12462, Greece

  • Aarhus Universitetshospital, Skejby

    Aarhus, N, 8200, Denmark

  • Bamrasnaradura Infections Diseases Institute (613-007)

    Nonthaburi, 11000, Thailand

  • Bispebjerg Hospital

    Copenhagen, 2400, Denmark

  • CAP Can Bou

    Castelldefels, Barcelona, 08860, Spain

  • CAP Corbera

    Barcelona, 08757, Spain

  • CAP El Maresme

    Mataró, Barcelona, 08303, Spain

  • CHRISTUS Spohn Shoreline Hospital

    Corpus Christi, Texas, 78404, United States

  • Carilion Medical Center (Site 080-018)

    Roanoke, Virginia, 24015, United States

  • Central City Clinical Hospital of Ivano-Frankivsk City Council

    Ivano-Frankivsk, 76018, Ukraine

  • Centro de Investigaciones Medicas de Mar del Plata (Site 611-031)

    Mar del Plata, Buenos Aires, B7600FYK, Argentina

  • Chulalongkorn University and The HIV-NAT

    Pathum Wan, Bangkok, 10330, Thailand

  • Cleveland Clinic Foundation (Site 207-001)

    Cleveland, Ohio, 44195, United States

  • Clínica Central S.A. (611-028)

    Villa Regina, Río Negro Province, R8336, Argentina

  • Department of Clinical Therapeutics of Alexandra Hospital

    Athens, Attica, 11528, Greece

  • Department of Infectious Diseases

    Aalborg, 9000, Denmark

  • Dept of Critical Care and Pulmonary Medicine, Evangelismos General Hospital

    Athens, Attica, 10676, Greece

  • Henry Ford Health System Site (014-001)

    Detroit, Michigan, 48202, United States

  • Herlev/Gentofte Hospital

    Hellerup, 2900, Denmark

  • Hospital General Dr. Aurelio Valdivieso

    Oaxaca City, OA, 68050, Mexico

  • Hospital General Dr. Manuel Gea Gonzáles

    Mexico City, Mexico City, 14080, Mexico

  • Hospital General de Agudos JM Ramos Mejia

    Buenos Aires, C1221ADC, Argentina

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Hvidovre University Hospital, Department of Infectious Diseases

    Hvidovre, 2650, Denmark

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Instituto Medico Platense

    La Plata, Buenos Aires, B1900AVG, Argentina

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

    Mexico City, Mexico City, 14080, Mexico

  • Instituto Nacional de Enfermedades Respiratorias Ismael Cosió Villegas

    Mexico City, Mexico City, 14080, Mexico

  • Intermountain Medical Center (211-001)

    Murray, Utah, 84107, United States

  • Joint Clinical Research Center (JCRC)

    Kampala, Uganda

  • Khon Kaen University, Srinagarind Hospital (Site 613-003)

    Khon Kaen, 40002, Thailand

  • Kolding Sygehus

    Kolding, 6000, Denmark

  • Laiko Athens General Hospital

    Athens, Attica, 11527, Greece

  • Lira Regional Referral Hospital

    Lira, Uganda

  • MRC/UVRI & LSHTM Uganda Research Unit

    Entebbe, Uganda

  • Makerere University Lung Institute (Site 634-604)

    Kampala, Uganda

  • Masaka Regional Referral Hospital

    Masaka, Uganda

  • Odense University Hospital

    Odense, C, 5000, Denmark

  • Penn State Health Milton S. Hershey Medical Center (209-002)

    Hershey, Pennsylvania, 17033, United States

  • Rigshospitalet, CHIP

    Copenhagen, 2100, Denmark

  • Rocky Mountain Regional VA Medical Center (074-010)

    Aurora, Colorado, 80045, United States

  • Royal Victoria Infirmary

    Newcastle upon Tyne, NE1 4LP, United Kingdom

  • Salem VA Medical Center (074-014)

    Salem, Virginia, 24153, United States

  • San Francisco VAMC (Site 074-002)

    San Francisco, California, 94121, United States

  • Siriraj Hospital (Site 613-002)

    Bangkok Noi, Bangkok, 10700, Thailand

  • Southern Arizona VA Healthcare System (074-009)

    Tucson, Arizona, 85723, United States

  • St. Francis Hospital, Nsambya

    Kampala, Uganda

  • St. Vincent's Hospital

    Sydney, New South Wales, 2010, Australia

  • Stanford University Hospital & Clinics (Site 203-003)

    Palo Alto, California, 94305, United States

  • Swedish Hospital First Hill

    Seattle, Washington, 98122, United States

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • UVA Health System, University Hospital (Site 210-003)

    Charlottesville, Virginia, 22908, United States

  • Unidad de Ensayos Clinicos Socios En Salud Sucursal Perú (651-009)

    Lima, 15012, Peru

  • University College London Hospitals

    London, WC1E 6JB, United Kingdom

  • University Malaya Medical Centre (Site 612-501)

    Kuala Lumpur, Kuala Lumpur, 59100, Malaysia

  • VA Northern California Health Care System (074-023)

    Mather, California, 95655, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Anti-COVID-19 hyperimmune intravenous immunoglobulin (hIVIG)

What this could lead to

If it works, this could provide a new treatment option for early COVID-19 in high-risk outpatients, reducing severe illness and hospital stays.

What could go wrong

This trial is suspended, so results are unknown. The treatment may not improve outcomes over placebo, and risks like infusion reactions or lack of benefit are possible.

Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.