Could a single infusion of COVID-Fighting antibodies keep High-Risk patients out of the hospital?

NCT ID NCT04910269

Terminated Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This study tests whether a single infusion of hyperimmune immunoglobulin (hIVIG) — concentrated antibodies from recovered COVID-19 patients — can help adults at high risk (age 55+ or with weakened immune systems) who have early COVID-19. Participants receive either the antibody infusion or a placebo (salt water) and are followed for 28 days to see if they recover faster or avoid hospitalization. The trial was suspended, so results are not yet available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Anti-COVID-19 hyperimmune intravenous immunoglobulin (hIVIG)
What this could lead to: If it works, this could provide a new treatment option for early COVID-19 in high-risk outpatients, reducing severe illness and hospital stays.
What could go wrong: This trial is suspended, so results are unknown. The treatment may not improve outcomes over placebo, and risks like infusion reactions or lack of benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID COVID19 SARS-COV2 INFECTION

Contacts and locations

Locations

3rd Dept of Medicine, Medical School

Athens, Attica, 11527, Greece
4th Department of Internal Medicine

Athens, Attica, 12462, Greece
Aarhus Universitetshospital, Skejby

Aarhus, N, 8200, Denmark
Bamrasnaradura Infections Diseases Institute (613-007)

Nonthaburi, 11000, Thailand
Bispebjerg Hospital

Copenhagen, 2400, Denmark
CAP Can Bou

Castelldefels, Barcelona, 08860, Spain
CAP Corbera

Barcelona, 08757, Spain
CAP El Maresme

Mataró, Barcelona, 08303, Spain
CHRISTUS Spohn Shoreline Hospital

Corpus Christi, Texas, 78404, United States
Carilion Medical Center (Site 080-018)

Roanoke, Virginia, 24015, United States
Central City Clinical Hospital of Ivano-Frankivsk City Council

Ivano-Frankivsk, 76018, Ukraine
Centro de Investigaciones Medicas de Mar del Plata (Site 611-031)

Mar del Plata, Buenos Aires, B7600FYK, Argentina
Chulalongkorn University and The HIV-NAT

Pathum Wan, Bangkok, 10330, Thailand
Cleveland Clinic Foundation (Site 207-001)

Cleveland, Ohio, 44195, United States
Clínica Central S.A. (611-028)

Villa Regina, Río Negro Province, R8336, Argentina
Department of Clinical Therapeutics of Alexandra Hospital

Athens, Attica, 11528, Greece
Department of Infectious Diseases

Aalborg, 9000, Denmark
Dept of Critical Care and Pulmonary Medicine, Evangelismos General Hospital

Athens, Attica, 10676, Greece
Henry Ford Health System Site (014-001)

Detroit, Michigan, 48202, United States
Herlev/Gentofte Hospital

Hellerup, 2900, Denmark
Hospital General Dr. Aurelio Valdivieso

Oaxaca City, OA, 68050, Mexico
Hospital General Dr. Manuel Gea Gonzáles

Mexico City, Mexico City, 14080, Mexico
Hospital General de Agudos JM Ramos Mejia

Buenos Aires, C1221ADC, Argentina
Hospital Universitari Germans Trias i Pujol

Badalona, Barcelona, 08916, Spain
Hvidovre University Hospital, Department of Infectious Diseases

Hvidovre, 2650, Denmark
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Instituto Medico Platense

La Plata, Buenos Aires, B1900AVG, Argentina
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Mexico City, Mexico City, 14080, Mexico
Instituto Nacional de Enfermedades Respiratorias Ismael Cosió Villegas

Mexico City, Mexico City, 14080, Mexico
Intermountain Medical Center (211-001)

Murray, Utah, 84107, United States
Joint Clinical Research Center (JCRC)

Kampala, Uganda
Khon Kaen University, Srinagarind Hospital (Site 613-003)

Khon Kaen, 40002, Thailand
Kolding Sygehus

Kolding, 6000, Denmark
Laiko Athens General Hospital

Athens, Attica, 11527, Greece
Lira Regional Referral Hospital

Lira, Uganda
MRC/UVRI & LSHTM Uganda Research Unit

Entebbe, Uganda
Makerere University Lung Institute (Site 634-604)

Kampala, Uganda
Masaka Regional Referral Hospital

Masaka, Uganda
Odense University Hospital

Odense, C, 5000, Denmark
Penn State Health Milton S. Hershey Medical Center (209-002)

Hershey, Pennsylvania, 17033, United States
Rigshospitalet, CHIP

Copenhagen, 2100, Denmark
Rocky Mountain Regional VA Medical Center (074-010)

Aurora, Colorado, 80045, United States
Royal Victoria Infirmary

Newcastle upon Tyne, NE1 4LP, United Kingdom
Salem VA Medical Center (074-014)

Salem, Virginia, 24153, United States
San Francisco VAMC (Site 074-002)

San Francisco, California, 94121, United States
Siriraj Hospital (Site 613-002)

Bangkok Noi, Bangkok, 10700, Thailand
Southern Arizona VA Healthcare System (074-009)

Tucson, Arizona, 85723, United States
St. Francis Hospital, Nsambya

Kampala, Uganda
St. Vincent's Hospital

Sydney, New South Wales, 2010, Australia
Stanford University Hospital & Clinics (Site 203-003)

Palo Alto, California, 94305, United States
Swedish Hospital First Hill

Seattle, Washington, 98122, United States
UT Southwestern Medical Center

Dallas, Texas, 75390, United States
UVA Health System, University Hospital (Site 210-003)

Charlottesville, Virginia, 22908, United States
Unidad de Ensayos Clinicos Socios En Salud Sucursal Perú (651-009)

Lima, 15012, Peru
University College London Hospitals

London, WC1E 6JB, United Kingdom
University Malaya Medical Centre (Site 612-501)

Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
VA Northern California Health Care System (074-023)

Mather, California, 95655, United States

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