Could a single infusion of COVID-Fighting antibodies keep High-Risk patients out of the hospital?
NCT ID NCT04910269
First seen Nov 01, 2025 · Last updated Jun 15, 2026 · Updated 32 times
Summary
This study tests whether a single infusion of anti-COVID-19 hyperimmune immunoglobulin (hIVIG) can improve symptoms and prevent hospitalization in adults recently diagnosed with COVID-19 who are not sick enough to be hospitalized. Participants are at higher risk due to age (55+) or a weakened immune system. The trial compares hIVIG against a placebo and tracks how well patients feel after 7 days, as well as hospitalizations and deaths over 28 days.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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3rd Dept of Medicine, Medical School
Athens, Attica, 11527, Greece
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4th Department of Internal Medicine
Athens, Attica, 12462, Greece
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Aarhus Universitetshospital, Skejby
Aarhus, N, 8200, Denmark
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Bamrasnaradura Infections Diseases Institute (613-007)
Nonthaburi, 11000, Thailand
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Bispebjerg Hospital
Copenhagen, 2400, Denmark
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CAP Can Bou
Castelldefels, Barcelona, 08860, Spain
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CAP Corbera
Barcelona, 08757, Spain
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CAP El Maresme
Mataró, Barcelona, 08303, Spain
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CHRISTUS Spohn Shoreline Hospital
Corpus Christi, Texas, 78404, United States
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Carilion Medical Center (Site 080-018)
Roanoke, Virginia, 24015, United States
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Central City Clinical Hospital of Ivano-Frankivsk City Council
Ivano-Frankivsk, 76018, Ukraine
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Centro de Investigaciones Medicas de Mar del Plata (Site 611-031)
Mar del Plata, Buenos Aires, B7600FYK, Argentina
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Chulalongkorn University and The HIV-NAT
Pathum Wan, Bangkok, 10330, Thailand
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Cleveland Clinic Foundation (Site 207-001)
Cleveland, Ohio, 44195, United States
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Clínica Central S.A. (611-028)
Villa Regina, Río Negro Province, R8336, Argentina
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Department of Clinical Therapeutics of Alexandra Hospital
Athens, Attica, 11528, Greece
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Department of Infectious Diseases
Aalborg, 9000, Denmark
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Dept of Critical Care and Pulmonary Medicine, Evangelismos General Hospital
Athens, Attica, 10676, Greece
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Henry Ford Health System Site (014-001)
Detroit, Michigan, 48202, United States
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Herlev/Gentofte Hospital
Hellerup, 2900, Denmark
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Hospital General Dr. Aurelio Valdivieso
Oaxaca City, OA, 68050, Mexico
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Hospital General Dr. Manuel Gea Gonzáles
Mexico City, Mexico City, 14080, Mexico
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Hospital General de Agudos JM Ramos Mejia
Buenos Aires, C1221ADC, Argentina
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Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
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Hvidovre University Hospital, Department of Infectious Diseases
Hvidovre, 2650, Denmark
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Instituto Medico Platense
La Plata, Buenos Aires, B1900AVG, Argentina
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Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, Mexico City, 14080, Mexico
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Instituto Nacional de Enfermedades Respiratorias Ismael Cosió Villegas
Mexico City, Mexico City, 14080, Mexico
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Intermountain Medical Center (211-001)
Murray, Utah, 84107, United States
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Joint Clinical Research Center (JCRC)
Kampala, Uganda
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Khon Kaen University, Srinagarind Hospital (Site 613-003)
Khon Kaen, 40002, Thailand
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Kolding Sygehus
Kolding, 6000, Denmark
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Laiko Athens General Hospital
Athens, Attica, 11527, Greece
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Lira Regional Referral Hospital
Lira, Uganda
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MRC/UVRI & LSHTM Uganda Research Unit
Entebbe, Uganda
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Makerere University Lung Institute (Site 634-604)
Kampala, Uganda
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Masaka Regional Referral Hospital
Masaka, Uganda
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Odense University Hospital
Odense, C, 5000, Denmark
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Penn State Health Milton S. Hershey Medical Center (209-002)
Hershey, Pennsylvania, 17033, United States
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Rigshospitalet, CHIP
Copenhagen, 2100, Denmark
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Rocky Mountain Regional VA Medical Center (074-010)
Aurora, Colorado, 80045, United States
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Royal Victoria Infirmary
Newcastle upon Tyne, NE1 4LP, United Kingdom
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Salem VA Medical Center (074-014)
Salem, Virginia, 24153, United States
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San Francisco VAMC (Site 074-002)
San Francisco, California, 94121, United States
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Siriraj Hospital (Site 613-002)
Bangkok Noi, Bangkok, 10700, Thailand
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Southern Arizona VA Healthcare System (074-009)
Tucson, Arizona, 85723, United States
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St. Francis Hospital, Nsambya
Kampala, Uganda
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St. Vincent's Hospital
Sydney, New South Wales, 2010, Australia
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Stanford University Hospital & Clinics (Site 203-003)
Palo Alto, California, 94305, United States
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Swedish Hospital First Hill
Seattle, Washington, 98122, United States
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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UVA Health System, University Hospital (Site 210-003)
Charlottesville, Virginia, 22908, United States
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Unidad de Ensayos Clinicos Socios En Salud Sucursal Perú (651-009)
Lima, 15012, Peru
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University College London Hospitals
London, WC1E 6JB, United Kingdom
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University Malaya Medical Centre (Site 612-501)
Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
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VA Northern California Health Care System (074-023)
Mather, California, 95655, United States
Conditions
Explore the condition pages connected to this study.