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Nasal spray aims to fight COVID-19, but trial halted early

NCT ID NCT05541510

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a nasal spray called AD17002 in 180 adults with mild to moderate COVID-19. Participants received either a low dose, high dose, or placebo spray alongside standard care. The goal was to see if the spray speeds up recovery and improves symptoms. However, the trial was terminated early, so we have limited data on its effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AD17002 (LTh[αK]) intranasal spray
What this could lead to
If successful, this could provide a new treatment option for mild to moderate COVID-19 that boosts nasal immunity.
What could go wrong
The trial was terminated early, so results are limited. It is unclear if the treatment works better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

180 people

The number who actually took part.

Started

Dec 2022

Finished

Aug 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged ≥ 18 and ≤65 years old. 2. Laboratory confirmed SARS-CoV-2 infection, with first positive PCR test results within the past 48 hours of randomization. 3. Participants with COVID-19 symptoms within 5 days prior to the day of randomization, based on the following criteria: At least TWO of the following symptoms: Stuffy/runny nose, sore throat, shortness of breath, cough, low energy/tiredness, muscle/body aches, headache, chill/shivering, Fever (≥ 38ºC), nausea, vomiting, diarrhea, and loss of taste or smell. 4. Have a mild or moderate form of COVID-19 defined as: respiratory rate ≤30 breaths per minute, heart rate ≤125 beats per minute; with saturation of oxygen (SpO2) ≥93% on room air at sea level No clinical signs listed in Inclusion Criteria #3 indicative of Severe Severity 5. Have a negative pregnancy test at Screening (for female participants of childbearing potential). 6. Participant or the participant's legal representative understands the study procedures, alternative treatments available, risks involved with the study, and voluntarily agrees to participate by giving written informed consent. 7. Provide written informed consent for the study and willing to adhere to dose regimen and visit schedules. Exclusion Criteria: 1. Participant has clinical signs suggestive of severe illnesses with SPO2≤94. 2. Sign of severe pneumonia as determined by treating physician on X-ray or SPO2 3. Participant has CT≥25 at screening 4. Participation in any other clinical study of an investigational agent treatment for SARS-CoV-2 infection within 30 days prior to the first IMP dosing. 5. Concurrent treatment with other agents with actual or possible direct acting antiviral activity against SARS-CoV-2 prior to PCR screening. 6. Participant with breakthrough SARS-CoV-2 infection within 2 weeks of SARS-CoV-2 vaccination. 7. History of severe renal disease (treatment with dialysis or phosphate binders) or clinically apparent hepatic impairment (e.g., jaundice, cholestasis, hepatic synthetic impairment, active hepatitis). 8. Impaired cardiac function or clinically significant cardiac diseases as judged by the Investigator. 9. History of anaphylaxis reaction to any known or unknown cause. 10. Immunosuppressed persons as result of illness (e.g., HIV infection) or treatment. 11. Documented history of Bell's palsy. 12. History of allergic reaction to kanamycin. 13. Immunosuppressive treatment within 3 months prior to the Screening Visit. 14. Intranasal medication or nasal topical treatment at the time of screen and study. 15. Assessed by the Investigator to be ineligible to participate in the study.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • RSA UGM

    Yogyakarta, Special Region of Yogyakarta, 55281, Indonesia

  • RSDC Wisma Atlit

    Kota Jkt Utara, DKI Jakarta, 14360, Indonesia

  • RSPI Sulianti Saroso

    Kota Jkt Utara, DKI Jakarta, 14340, Indonesia

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