Nasal spray aims to fight COVID-19, but trial halted early
NCT ID NCT05541510
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested a nasal spray called AD17002 in 180 adults with mild to moderate COVID-19. Participants received either a low dose, high dose, or placebo spray alongside standard care. The goal was to see if the spray speeds up recovery and improves symptoms. However, the trial was terminated early, so we have limited data on its effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- AD17002 (LTh[αK]) intranasal spray
- What this could lead to
- If successful, this could provide a new treatment option for mild to moderate COVID-19 that boosts nasal immunity.
- What could go wrong
- The trial was terminated early, so results are limited. It is unclear if the treatment works better than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
180 people
The number who actually took part.
- Started
-
Dec 2022
- Finished
-
Aug 2024
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged ≥ 18 and ≤65 years old. 2. Laboratory confirmed SARS-CoV-2 infection, with first positive PCR test results within the past 48 hours of randomization. 3. Participants with COVID-19 symptoms within 5 days prior to the day of randomization, based on the following criteria: At least TWO of the following symptoms: Stuffy/runny nose, sore throat, shortness of breath, cough, low energy/tiredness, muscle/body aches, headache, chill/shivering, Fever (≥ 38ºC), nausea, vomiting, diarrhea, and loss of taste or smell. 4. Have a mild or moderate form of COVID-19 defined as: respiratory rate ≤30 breaths per minute, heart rate ≤125 beats per minute; with saturation of oxygen (SpO2) ≥93% on room air at sea level No clinical signs listed in Inclusion Criteria #3 indicative of Severe Severity 5. Have a negative pregnancy test at Screening (for female participants of childbearing potential). 6. Participant or the participant's legal representative understands the study procedures, alternative treatments available, risks involved with the study, and voluntarily agrees to participate by giving written informed consent. 7. Provide written informed consent for the study and willing to adhere to dose regimen and visit schedules. Exclusion Criteria: 1. Participant has clinical signs suggestive of severe illnesses with SPO2≤94. 2. Sign of severe pneumonia as determined by treating physician on X-ray or SPO2 3. Participant has CT≥25 at screening 4. Participation in any other clinical study of an investigational agent treatment for SARS-CoV-2 infection within 30 days prior to the first IMP dosing. 5. Concurrent treatment with other agents with actual or possible direct acting antiviral activity against SARS-CoV-2 prior to PCR screening. 6. Participant with breakthrough SARS-CoV-2 infection within 2 weeks of SARS-CoV-2 vaccination. 7. History of severe renal disease (treatment with dialysis or phosphate binders) or clinically apparent hepatic impairment (e.g., jaundice, cholestasis, hepatic synthetic impairment, active hepatitis). 8. Impaired cardiac function or clinically significant cardiac diseases as judged by the Investigator. 9. History of anaphylaxis reaction to any known or unknown cause. 10. Immunosuppressed persons as result of illness (e.g., HIV infection) or treatment. 11. Documented history of Bell's palsy. 12. History of allergic reaction to kanamycin. 13. Immunosuppressive treatment within 3 months prior to the Screening Visit. 14. Intranasal medication or nasal topical treatment at the time of screen and study. 15. Assessed by the Investigator to be ineligible to participate in the study.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for COVID-19 are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
RSA UGM
Yogyakarta, Special Region of Yogyakarta, 55281, Indonesia
-
RSDC Wisma Atlit
Kota Jkt Utara, DKI Jakarta, 14360, Indonesia
-
RSPI Sulianti Saroso
Kota Jkt Utara, DKI Jakarta, 14340, Indonesia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Does COVID-19 hide in the gut? scientists probe stool for clues
- Blood samples and health records could reveal why some COVID-19 cases turn severe
- Home antibody tests put to the test: can you read your own COVID-19 result?
- Can lung ultrasound reveal COVID-19's signature in the lungs?
- When the immune system Can't fight back: tracking three respiratory viruses
- The household maze: how does COVID-19 move between family members?