Kidney failure

This trial tests whether giving diuretics based on bioimpedance analysis, a body scan that measures fluid levels, can slow heart failure progression in people who have no visible signs of congestion. Participants are adults with heart failure and a reduced ejection fraction, but …

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. Participants used the new filter three times a week for 12 weeks. The goal was to see if it safely maintained albumin levels while improving removal of certain waste products. The trial is …

This trial asks whether an intravenous (IV) injection of vitamin B12 works better than oral tablets to correct B12 deficiency in adults on long-term hemodialysis. Participants receive either a weekly IV dose after dialysis or oral tablets three times a day for four weeks. Researc…

This trial is testing whether a lab-grown human blood vessel (called a Human Acellular Vessel) can serve as a better connection point for hemodialysis than the standard synthetic grafts. People with end-stage kidney disease who need dialysis often require a reliable access point …

This phase 2 trial is testing whether colchicine, a drug used for gout, can safely reduce inflammation and potentially lower heart injury in people with advanced chronic kidney disease or on dialysis. Participants take colchicine daily for 16 weeks, starting at a low dose and the…

This study tests whether starting haemodialysis with fewer sessions per week (twice instead of the standard three times) can help preserve patients' remaining natural kidney function. New dialysis patients who still have some kidney function are randomly assigned to either standa…

This trial tests whether repeatedly adding sterile fluid into the womb can help fetuses with severe kidney failure grow enough lungs to survive after birth. Pregnant women with early pregnancy kidney failure can choose to receive the infusions or just be monitored. Babies who sur…

This study tested two different combinations of immunosuppressant drugs in 88 adults who received a new kidney. The goal was to see which plan better protects kidney function over the short term. All participants took lifelong anti-rejection medication, so this is about managing …

This study looked at whether giving kidney transplant patients a lower dose of the drug cyclosporine could protect their kidney function over time. 208 patients who were at least one year post-transplant and on stable medications took part. The goal was to balance preventing orga…

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This study tested whether using sevoflurane gas for anesthesia during kidney transplant surgery helps the new kidney recover faster than standard propofol anesthesia. 120 adults receiving a kidney transplant were randomly assigned to one of the two anesthetics. Researchers tracke…

This study looked at whether using a very small amount of contrast dye (less than 15 ml) is safe and works for opening blocked leg arteries in 18 patients with both severe leg ischemia and kidney impairment. The goal was to save the leg while protecting the kidneys. Results focus…

This study tested the drug dapagliflozin (a diabetes medicine) against a placebo in 220 people on dialysis for kidney failure, with or without diabetes. The goal was to see if the drug could improve heart structure and be safe. Participants took the drug or placebo for a period, …

This early-stage study tested an experimental diabetes drug called TA-7284 in 24 people with type 2 diabetes, some with normal kidneys and some with moderate kidney impairment. Researchers measured how the drug moves through the body, how it affects blood sugar, and whether it is…

This study tested a new device called the FLEX System that creates a connection between an artery and a vein (AV fistula) using a tube inserted through the skin, instead of surgery. The goal was to see if this method is safe and works well for people with chronic kidney disease w…

This phase 3 trial tested a lab-grown blood vessel (Human Acellular Vessel, or HAV) against the standard surgically created fistula in 242 people with end-stage kidney disease on hemodialysis. The goal was to see which option works better for providing reliable access to filter b…

This study looked at whether raising hemoglobin levels with a drug called epoetin (Neorecormon) could improve quality of life and slow kidney function decline in people who had a kidney transplant and now have chronic graft dysfunction. About 128 adults who had a transplant 1 to …

This study tested whether clopidogrel, a blood thinner, could prevent early failure of arteriovenous fistulas in 877 people with kidney failure starting hemodialysis. While clopidogrel reduced the risk of fistula clotting, it did not improve the chance that the fistula would be u…

This study looked at whether people with kidney failure who still have some kidney function can do well with only two dialysis sessions per week instead of the usual three. Fifty-eight patients each tried both schedules for four weeks. Researchers measured quality of life, sympto…

This study tested a new ultrasound technique called URM to look at tiny blood vessels in the kidneys of 150 people with kidney failure. The goal was to see if this method can help doctors better assess kidney function, stage the disease, and monitor treatment. The researchers com…

This study tested whether advanced ultrasound techniques can predict if an arteriovenous fistula (AVF) will work for dialysis in people with end-stage kidney disease. Researchers measured artery stiffness and blood flow in 76 patients before and after AVF surgery. The goal was to…

This trial asks whether giving dialysis patients four doses of a double-strength hepatitis B vaccine offers better protection than the standard three doses. People with kidney failure on dialysis often respond weakly to vaccines, leaving many unprotected. The study will compare a…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

This study tests whether wearing virtual reality glasses and watching a calming nature video during hemodialysis can help lower anxiety and keep vital signs stable. Researchers are enrolling 56 adults who are receiving dialysis for the first time. Half will watch a 4K nature vide…

This study tested whether listening to live or recorded music during dialysis can reduce pain, itch, anxiety, and depression. 102 adults on dialysis took part. They had one week of normal dialysis for baseline data, then a week with live music, then a week with recorded music. Re…

This study tested if hand reflexology massage could reduce fatigue and anxiety in adults with end-stage kidney disease who are on maintenance hemodialysis. 70 patients were split into two groups: one received eight 21-minute hand massage sessions during dialysis over four weeks, …

This study tested whether a 16-week program of cycling during dialysis sessions could improve heart function in 30 adults with kidney failure and early signs of heart stiffness. Participants first received standard care for 16 weeks, then added supervised cycling during dialysis …

This study compared two types of nerve blocks (ESPB and QLB) for pain control after laparoscopic kidney removal. Sixty-two adults having living-donor nephrectomy received one of the two blocks before surgery. The main goal was to see which block reduced the need for opioid pain m…

This study tested whether a nerve block called an erector spinae plane (ESP) block can reduce pain and the need for strong painkillers after a kidney transplant. Forty adults having a kidney transplant were randomly assigned to receive either the ESP block or no block. All patien…

This study looked at how the drug remibrutinib behaves in people with severe kidney problems compared to healthy people. Researchers measured drug levels in blood and urine to understand how the kidneys process it. The goal is to help doctors decide the right dose for patients wi…

This early-stage study is testing a single dose of the drug MK-2828 in 24 people with different levels of kidney function, including those with severe kidney failure or on dialysis. The goal is to measure how the drug moves through the body over time and compare it to healthy vol…

This study looks back at treatment records from 119 people with kidney failure who underwent haemodialysis using Genius SleddFlux filters, Ultraflux AV 600 S filters, and Genius 90 concentrates. The goal is to assess how well these devices performed in acute and chronic dialysis …

This study looks at how the body handles a new drug called S-892216 in people with mild, moderate, or severe kidney problems, including those on dialysis, compared to people with healthy kidneys. About 40 adults will take a single dose of the drug, and researchers will measure it…

This early-stage study looks at how a single dose of VC005 tablets is processed in people with kidney impairment compared to those with normal kidney function. Researchers will measure drug levels in the blood and check safety. The goal is to understand if kidney problems affect …

This study looks at thousands of Chinese adults aged 60 and older to understand how kidney function changes with age. Researchers are examining a range of blood and urine markers to see which ones best predict kidney failure, heart problems, and death. They are also testing diffe…

This early-stage study is testing a single dose of the drug combination bemnifosbuvir/ruzasvir in 28 adults. Some participants have severe kidney or liver impairment, while others are healthy. The goal is to see how the body processes the drug and whether it is safe in these grou…

This study looked at 64 adults hospitalized for acute heart failure to see if a blood marker called cystatin C could detect early kidney problems caused by diuretic treatment. Researchers measured cystatin C levels daily and compared them to standard kidney tests. The goal was to…

This study looked at how the tuberculosis drug pretomanid is processed in people with different levels of kidney function. Twelve participants received a single 200 mg dose, and researchers compared drug levels in those with kidney impairment to healthy matched controls. The goal…

This study looked at how the drug MCI-186 is handled by the body in people with mild or moderate kidney impairment compared to those with normal kidneys. Thirty adults received a single dose of the drug, and researchers measured its levels in the blood. The goal was to understand…

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This study examines whether common blood test results — such as markers of inflammation and nutrition — can help predict which patients are at higher risk of complications or death after surgery for acute aortic dissection. Researchers will review medical records from about 127 p…

This study examines how the sleep aid YZJ-1139 behaves in people with severe kidney impairment compared to those with normal kidney function. Sixteen adults will receive a single 20 mg dose, and researchers will measure drug levels in the blood and urine, as well as any side effe…

This study looks at how a single dose of the antibiotic levornidazole is processed by the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers will measure drug levels in the blood and urine, and monitor safety. The goal is to under…

This completed study looked at how the drug opemalirsen (AZD2373) is processed in people with different levels of kidney function. Researchers gave a single injection to 35 adults, some with kidney impairment and some with healthy kidneys. The goal was to compare drug levels and …

This study looked at how the drug LY3502970 behaves in people with healthy kidneys compared to those with kidney problems. Researchers measured how much drug gets into the blood and how fast the body clears it. The goal is to understand if kidney impairment changes drug levels, w…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormo…

This study looked at how a single dose of HR17031 moves through the body in people with mild, moderate, severe, or end-stage kidney disease compared to those with normal kidneys. A total of 24 adults with type 2 diabetes took part. The goal was to understand how kidney function a…

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study looked at how different levels of kidney function affect the way the drug enpatoran moves through the body. 34 adults with normal or impaired kidney function received a single dose of enpatoran. Researchers measured drug levels in the blood and monitored for side effec…

This study looked at how the drug LY3537031 moves through the body in people with different levels of kidney function. It included 31 adults with normal kidneys, kidney impairment, or end-stage kidney disease. The goal was to measure drug levels in the blood and how long it takes…

This completed Phase 1 study looked at how the drug LY3537982 is processed in people with different levels of kidney function. Researchers compared 32 participants with normal kidneys, moderate kidney problems, and severe kidney problems. The goal was to see how kidney impairment…

This study tracked 228 critically ill patients in China who needed continuous kidney dialysis. Doctors used pre-mixed solutions instead of custom-mixed ones to see how well they worked in everyday hospital care. The goal was to gather information on filter life, blood chemistry, …

This study looked at specific molecules in the blood of 180 people with chronic kidney disease (CKD) and 60 healthy volunteers. The goal was to see if these molecules could help diagnose CKD early or predict when a common treatment for anemia stops working. The researchers measur…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study looked at how different levels of kidney function affect the way the experimental brain drug iclepertin is processed in the body. 36 adults with and without kidney problems took a single dose of the drug. Researchers measured drug levels in the blood to see if kidney i…

This study tested whether having dialysis patients regularly fill out questionnaires about their symptoms and well-being helps them communicate better with their doctors and nurses. Over 3,900 adults on dialysis in Alberta and Ontario took part. The goal was to see if sharing the…

This study looks at how a single injection of BI 456906, a drug being developed for obesity and liver disease, behaves in the blood of people with different levels of kidney function. Researchers will compare drug levels in 42 adults with normal kidneys to those with mild, modera…

This study checked in on 5 adults with Fabry disease who had been taking enzyme replacement therapy (ERT) since childhood for about 15 years. Researchers measured kidney function and heart health to see how well the long-term treatment worked. The goal was to gather follow-up dat…

This study looked at how the drug BPN14770 moves through the body in people with severe kidney problems compared to healthy people. Researchers measured drug levels in the blood and checked for side effects. The goal was to understand if kidney function affects how the drug is pr…

This completed Phase 1 study looked at how the drug MK-8527 is processed in people with moderate or severe kidney impairment compared to healthy volunteers. Eighteen participants received a single oral dose, and researchers measured drug levels in the blood over time. The goal wa…

This study looks at how the drug calderasib (MK-1084) behaves in people with moderate or severe kidney problems compared to healthy volunteers. Researchers will measure drug levels in the blood after a single dose to see if kidney function changes how the body processes it. The s…

This study tested whether a non-invasive light sensor (near-infrared spectroscopy) placed on the skin over the kidney could measure oxygen levels during liver transplant surgery. Researchers monitored 41 patients to see if this method gives useful information about kidney functio…

This study tested a new weight-management drug called petrelintide in 39 people with normal or impaired kidney function. Researchers wanted to see if kidney problems change how the drug behaves in the body. The goal is to guide safe dosing for people with kidney issues who might …

This study looked at how kidney doctors (nephrologists) think about choosing the right dialysis treatment for patients with kidney failure. Researchers interviewed 25 doctors across Belgium to understand their beliefs and attitudes. The goal is to find out if doctors' own views a…

This study surveyed 158 kidney failure patients in Cairo government hospitals to find out what prevents them from joining renal rehabilitation programs. Researchers used a questionnaire to measure patients' views on exercise benefits and barriers. The goal is to identify key obst…

This study tested whether teaching dialysis staff and providing support to patients could reduce episodes of dangerously low blood pressure during treatment. Over 1,400 patients across multiple clinics took part. The goal was to make dialysis sessions safer and more stable.

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This study looked at whether a simple urine test could predict scarring in kidney transplants, instead of using a needle biopsy. Researchers measured certain genetic markers in urine cells from 300 kidney transplant recipients over the first year after transplant. The goal was to…

This completed study of 88 heart attack patients looked at why some develop kidney injury after receiving contrast dye during a procedure to open blocked arteries. Researchers analyzed medical records to find which factors—like age, lab results, or procedure details—were linked t…

This early-stage study tested the safety and tolerability of a new drug called KBP-5074 in 26 adults, including healthy volunteers and those with mild to moderate kidney impairment. Researchers measured how the drug moves through the body and its effects on blood pressure and pot…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were on different anti-retroviral regimens, and researchers compared the r…

This study tested whether a special type of MRI (multiparametric MRI) can reliably measure kidney function in people with metabolic syndrome—a cluster of conditions like obesity, high blood pressure, and high blood sugar. Researchers compared MRI results between 46 healthy volunt…

This completed phase 1 study looked at how different levels of kidney function affect the way the body processes a single dose of ESK-001, an experimental drug. Sixteen participants with healthy kidneys or mild, moderate, or severe kidney impairment each took one oral dose. Resea…

This completed Phase 1 study looked at how the drug AZD5462 behaves in people with reduced kidney function compared to healthy volunteers. Sixteen participants received a single oral dose, and researchers measured drug levels in the blood and monitored for side effects. The goal …

This study tested a new way to measure blood pressure in 90 people with severe kidney disease. The new method uses a different part of the blood pressure wave, and researchers wanted to see if it works as well as the standard arm cuff method. The goal was to find a more accurate …

This study tested whether having a clinical pharmacist work alongside doctors in a hospital ward could reduce medication errors in patients with kidney disease. Researchers followed 160 adults with reduced kidney function, comparing usual care, doctor education, and active pharma…

This early-phase study looked at how a single dose of the drug olpasiran moves through the body in people with normal kidneys and those with various levels of kidney impairment. Thirty-three adults received one shot under the skin. The main goal was to measure drug levels in the …

This study looked at how the drug BI 1015550 is processed in people with and without kidney problems. 26 adults took a single dose, and researchers measured drug levels in their blood. The goal was to see if kidney impairment changes how the drug is absorbed, to guide future dosi…

This completed study looked at how long nerve blocks last in people with kidney failure or diabetes compared to those without these conditions. Researchers gave 120 patients a truncal block during hand or wrist surgery and measured when sensation returned. The goal was to see if …

This completed Phase 1 study looked at how different levels of kidney function affect the way the body processes a single dose of the drug AZD6234. Researchers compared 24 adults with various degrees of kidney impairment to healthy volunteers. The goal was to understand how the d…

This study looked at how the experimental drug MBX 2109 is handled by the body in people with different levels of kidney function. 25 adults with normal or impaired kidneys received a single dose. The goal was to measure safety and drug levels, not to treat a disease. Results wil…

This completed Phase 1 study looked at how the drug resmetirom (Rezdiffra) is processed in the body of people with severe kidney impairment compared to healthy volunteers. 28 participants took a 100 mg pill once daily for 6 days. The goal was to measure drug levels and safety, no…

This study looked at how the drug BMS-986278 behaves in people with normal kidneys, severe kidney disease, or kidney failure on dialysis. 27 adults took a single dose to measure drug levels and check for side effects. The goal was to gather safety information, not to treat the di…

This study tested a clinical decision support tool called PREVENT to help nurses prioritize which patients need homecare most urgently after leaving the hospital. Researchers studied nearly 2,000 adults with conditions like diabetes, heart failure, and lung disease to see if the …

This study looked at whether a blood test called cystatin C is more accurate than the standard creatinine test for measuring kidney function in people with severe liver disease. Researchers compared these lab tests to a precise radioactive tracer method in 213 adults being evalua…

This completed Phase 1 study looked at how the drug SHR8554 injection behaves in 20 people with kidney problems compared to healthy volunteers. The goal was to measure drug levels and safety, not to treat pain. Results will help guide future dosing for patients with kidney issues…

This study looked at how the drug cenerimod is processed in people with severe kidney impairment compared to healthy people. A total of 16 participants took a single 0.5 mg dose of cenerimod. Researchers measured drug levels in the blood and checked safety markers like heart rhyt…

This study looked at whether the diabetes drug metformin can be used safely in people with type 2 diabetes who also have kidney disease. Researchers gave increasing doses of metformin to 82 patients with different stages of kidney failure and measured the drug levels in their red…

This study looked at how the body processes the drug selpercatinib (LOXO-292) in people with different levels of kidney function. Researchers gave a single dose to 37 volunteers—some with healthy kidneys and some with kidney impairment—and measured drug levels in the blood and ur…

This completed Phase 1 study looked at how HRS-1893 tablets are processed in people with mild or moderate kidney impairment compared to healthy subjects. The goal was to understand dosing needs for patients with hypertrophic cardiomyopathy who also have kidney issues. Twenty-four…