Inflammatory bowel disease

Researchers at Assiut University Children Hospital are studying whether a specially prepared medical milk formula called Modulen IBD can bring Crohn's disease into remission and keep it there in children and teenagers. About 40 young patients with mild to moderate active Crohn's …

Researchers are tracking how long adults with moderate to severe Crohn's disease or ulcerative colitis keep taking guselkumab, a biologic drug, in routine care. The study follows about 400 people who start the treatment and records when they stop. It also checks whether early imp…

This study tests whether oral vancomycin, an antibiotic, can help children aged 6-15 with inflammatory bowel disease (IBD), especially types linked to liver problems. About 140 kids will either get vancomycin plus standard care or standard care alone for up to a year. Researchers…

This trial tests whether adding Bacillus probiotic spores to standard treatment can help people with Crohn's disease or ulcerative colitis. Researchers will give 150 adults either a placebo or one of two probiotic formulas for 30 days, alongside their usual care. The goal is to s…

This phase 1 trial tests the safety and tolerability of LMT503, an oral drug intended for inflammatory bowel disease, in healthy adults aged 18 to 65. Participants receive either LMT503 or a placebo in single or multiple ascending doses, with some also checking how food affects t…

This trial tests an experimental oral treatment called R-3750, a live engineered bacterium designed to deliver a protein that may reduce gut inflammation. About 40 adults with active Crohn's disease will receive either R-3750 or a placebo capsule daily for 12 weeks. Researchers w…

This study tests whether hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — can help heal perianal fistulas in people with Crohn's disease who haven't improved with standard treatments. Participants will either receive HBOT or continue with conven…

This Phase 1 trial is testing an experimental oral drug called QLS1510, which is being developed for inflammatory bowel disease (IBD). The study enrolls healthy adults aged 18 to 45 to evaluate the drug's safety, tolerability, how it moves through the body, and the effect of food…

This trial tests whether tirzepatide (Zepbound) can reduce daily bowel frequency in adults with an ileal pouch-anal anastomosis (IPAA) who have chronic high bowel frequency despite standard anti-diarrheal therapy. Participants will be assigned to receive tirzepatide or standard c…

This trial is testing whether a probiotic supplement called Colipral, which contains a specific strain of E. coli bacteria, can improve gut health in people with ulcerative colitis who are in remission but still have digestive issues. Participants will take either the supplement …

This early-stage trial is testing whether a drug called aletekitug is safe and tolerable for people with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The drug works by blocking a protein called IL-18, which may play a role in the inflammation that …

This early trial is testing an experimental biologic drug called aletekitug in adults with moderate to severe ulcerative colitis. The main goal is to see if the drug is safe and tolerable when given repeatedly. Researchers will monitor side effects and changes in lab tests, vital…

This study tests an experimental tablet called Hemay005 in 360 Chinese adults with moderate to severe ulcerative colitis, a chronic gut condition. Participants will receive either the drug or a placebo to see if it can bring about remission and improve symptoms over 12 weeks, wit…

This early-phase study tests a new treatment called ICG318 CAR-T for people with inflammatory bowel disease (IBD) that hasn't improved with standard therapies. The treatment uses a patient's own immune cells, modified in a lab to target and calm the overactive immune response cau…

This study will follow 95 adults with moderate-to-severe Crohn's disease or ulcerative colitis in Upper Egypt who are taking one of five biologic drugs: adalimumab, infliximab, ustekinumab, golimumab, or vedolizumab. After one year, researchers will measure how many patients avoi…

This study tests whether fecal microbiota transplantation (FMT) can improve liver function in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). 72 participants will receive either FMT or a sham procedure via colonoscopy and later oral capsules…

This study tests if xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low or high dose of xylitol or a placebo for four weeks. Researchers …

This study tests whether adding a specific gut bacteria (Akkermansia muciniphila) to the standard drug infliximab helps heal the intestinal lining better than infliximab alone in people with Crohn's disease. About 400 adults with active Crohn's will be randomly assigned to one of…

This study tests whether adding palmitoleic acid (a natural fatty acid) to the standard drug infliximab helps heal the gut lining better than infliximab alone in people with Crohn's disease. About 400 adults with active Crohn's will take part. The main goal is to see if the combi…

This early-stage study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose, while also looking at how well it work…

This pilot study tests a new synbiotic formula (SGR11) in 50 adults with mild-to-moderate ulcerative colitis, a type of inflammatory bowel disease. Participants take the supplement daily for 8 weeks. Researchers will check if symptoms improve and if the supplement is safe, using …

This study tests a blood-filtering device called Efferon LPS in 40 adults with Crohn's disease or ulcerative colitis during a flare-up. The device is designed to remove harmful substances from the blood to reduce inflammation. Participants will either receive standard care alone …

This pilot study tests whether xylitol, a common sugar alcohol, can safely clear C. difficile bacteria from the guts of people with inflammatory bowel disease (IBD). About 69 adults with mild or inactive IBD will take different doses of xylitol for up to 8 weeks. Researchers will…

This study compares two antibiotics, fidaxomicin and vancomycin, to see which one is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 60 adults with IBD will take one of the two antibiotics for 10 days and be followed fo…

This study will follow 178 Chinese adults with Crohn's disease or ulcerative colitis who are starting treatment with IL-23 inhibitors (guselkumab or risankizumab). Researchers will track how well the drugs control symptoms and heal the gut over 52 weeks, as well as any side effec…

This study tests a new type of day hospital for people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. In one visit, patients get blood tests, a doctor checkup, education on managing their condition, and optional workshops on diet or fatigue. Th…

Researchers at the University of British Columbia are collecting intestinal ultrasound images from adults, including healthy people and those with inflammatory bowel disease such as Crohn disease or ulcerative colitis. The goal is to build a computer program that can measure bowe…

Researchers at Assiut University are testing whether a stool test for calprotectin, a protein linked to inflammation, can accurately detect gut inflammation in children with chronic digestive symptoms. The study will compare stool test results with findings from endoscopy and tis…

This study tests whether ratios of routine blood markers—like C-reactive protein-to-albumin and neutrophil-to-lymphocyte—can accurately tell if inflammatory bowel disease (IBD) is active or in remission. Adults with Crohn's disease or ulcerative colitis will have blood tests and …

This study tests whether combining two screening questionnaires with a musculoskeletal ultrasound can detect spondyloarthritis—a type of inflammatory arthritis—in people who already have inflammatory bowel disease (IBD) but have not been diagnosed with arthritis. Two hundred adul…

This study looks at whether a substance in urine, called PGE-MUM, can show if ulcerative colitis is active or in remission. Researchers will collect urine and blood samples from 114 adults with confirmed ulcerative colitis and compare the results with colonoscopy findings. If suc…

This study explores whether measuring two specific genes (NEAT1 and ANRIL) in blood samples can help diagnose inflammatory bowel disease (IBD) without needing a colonoscopy. Researchers will test blood from 62 newly diagnosed IBD patients and look for links between these genes an…

This study will check how useful endoscopy is for finding the cause of stomach and gut issues in 150 children from birth to 18 years old at Assiut University Children Hospital. The goal is to see how often the procedure gives a clear diagnosis and to track any risks. The results …

This study tests a mobile app designed to help Black and Hispanic adults with inflammatory bowel disease (IBD) manage stress and improve their quality of life. The app teaches coping skills, mindfulness, and disease acceptance. Researchers want to see if the app is practical and …

This trial tests whether a personalized 6-month exercise program can reduce persistent fatigue in people with inflammatory bowel disease (IBD) who are in remission. Researchers will randomly assign 120 participants to either the exercise program or usual care. Fatigue levels are …

This study tests whether an 8-week mindfulness-based stress reduction (MBSR) program can lower stress and improve well-being in people with inflammatory bowel disease (IBD). Seventy adults with mild-to-moderate IBD will either take the MBSR course online or watch an educational s…

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This study tests two online pain education programs for adults with Crohn's disease or ulcerative colitis who have chronic pain. Participants will complete a 2-hour online session and report their pain and quality of life weekly for 8 weeks. The goal is to see if these programs a…

This study tests whether a special liquid diet (elemental diet) can help adults with inflammatory bowel disease (IBD) feel better during a flare. The diet provides all nutrients in an easy-to-digest form. Researchers will track symptom changes and inflammation levels in 42 outpat…

This pilot study compares recorded gut-directed hypnosis to an educational recording for hospitalized patients with chronic gut problems, such as irritable bowel syndrome or inflammatory bowel disease. Participants listen to the recordings over the phone while in the hospital for…

This study tests whether giving a drug called dexmedetomidine for 48 hours after laparoscopic bowel surgery helps patients recover better. About 70 adults will receive either the drug or a placebo, and neither they nor their doctors will know which. The main goal is to see if the…

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy (VR/AI CBT) program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). Seventy-six adults with IBD and moderate-to-severe anxiety will be randomly ass…

This study tests whether neurofeedback — a type of brain training using real-time brainwave feedback — can reduce musculoskeletal pain in people with chronic inflammatory bowel disease (IBD). Eighty adults with IBD and persistent pain will be randomly assigned to either 8 session…

This study tests a dietary supplement called GenesiDol for managing muscle and joint pain in people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. About 40 adults with persistent pain will take the supplement for 8 weeks to see if it reduces pa…

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study tests whether remimazolam, a newer sedative, works as well as or better than midazolam for colonoscopy in 200 adults with inflammatory bowel disease (Crohn's or colitis). Participants get one of the two drugs plus fentanyl for pain, then rate their satisfaction and are…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…

Researchers are observing 300 adults aged 60 and older with inflammatory bowel disease who are starting an advanced therapy chosen by their usual care team. The study tracks immune-aging markers such as CD4/CD8 ratio and IL-6, along with frailty and nutrition, over 52 weeks. The …

Researchers are testing whether blocking three inflammation pathways at once (TL1A, IL-23, and α4β7) calms inflamed intestinal tissue more effectively than blocking each pathway alone. The study enrolls 30 people: 10 with ulcerative colitis, 10 with Crohn's disease, and 10 withou…

This study looks at how anxiety, depression, and stress might cause advanced IBD treatments to stop working. Researchers will ask 450 people with IBD to fill out questionnaires about their mental health while they receive regular infusions. The goal is to understand if mental hea…

Researchers at Assiut University Children Hospital are comparing conventional and biologic therapies in children and adolescents with inflammatory bowel disease, including Crohn's disease and ulcerative colitis. The study tracks about 100 patients to measure clinical remission at…

This study is exploring whether a rapid, non-invasive stool test can help monitor inflammatory bowel disease (IBD) in children. The test uses a technology called differential mobility spectrometry (DMS) to analyze the molecular profile of stool samples. Researchers will compare t…

Some people with inflammatory bowel disease who take anti-TNF drugs develop painful rashes in skin folds and around the mouth, a condition called SPIDER. Researchers at a French hospital are studying whether levels of Staphylococcus aureus bacteria in these rashes change over six…

Researchers at Assiut University are studying how nutrition, diet-related inflammation, and blood markers relate to disease activity in people with inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. The study will enroll 100 adults aged 18 to…

This study will test a new type of colonoscope called the Magnetic Flexible Endoscope (MFE) in 6 people with inflammatory bowel disease (IBD). The MFE uses a magnet at its tip, moved by an external robotic arm, to gently travel through the colon. The goal is to see if it can reac…

This study investigates why children with inflammatory bowel disease (IBD) have an overactive immune response in the gut, and whether blood stem cells can be engineered to restore tolerance. Researchers will analyze blood and intestinal tissue samples from 80 children with IBD, w…

This lab study tests whether a cell-free mixture of molecules and particles released by human amniotic mesenchymal stromal cells can reduce inflammation, prevent scarring, and promote healing in gut tissue from people with inflammatory bowel disease (Crohn's disease or ulcerative…

This study looks at medical records from thousands of adults with Crohn's disease or ulcerative colitis treated in Dutch hospitals between 2018 and 2026. Researchers will analyze which treatments patients receive, how often they switch therapies, and how the disease affects other…

This study investigates whether acupuncture points become tender or more sensitive in people with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Researchers will compare skin temperature, blood flow, and pain sensitivity at specific body points b…

This study explores whether changes in heart rate, sleep, and activity measured by a person's own smartwatch can predict flare-ups in inflammatory bowel disease (IBD). Six hundred adults with Crohn's disease or ulcerative colitis who already own a compatible device will participa…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study looks at whether it's safe to skip mechanical bowel preparation (the drink that cleans out your colon) before colon surgery. Currently, the best practice combines that drink with antibiotics to prevent infections. The trial will compare two groups: one getting the drin…

This study tests whether watching a short video tailored to their specific type of inflammatory bowel disease (IBD) helps patients better prepare their bowel for a colonoscopy. About 600 adults with ulcerative colitis or Crohn's disease will be randomly assigned to receive either…

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study looks at a new way to control inflammation during flare-ups of Crohn's disease and ulcerative colitis. Researchers will take blood samples from 30 adults with severe IBD and test whether oxygen microbubbles can reprogram immune cells (monocytes) to produce fewer inflam…

This study will test whether an artificial intelligence (AI) system can help doctors identify inflammatory bowel disease (IBD) earlier and more accurately. Researchers will analyze medical records from 4,500 patients to see how well the AI's suggestions match actual diagnoses. Th…

This study looks at the eating habits of 50 pregnant women with inflammatory bowel disease (IBD). Researchers want to see if better diet quality is linked to healthier pregnancies and baby growth. The goal is to find nutritional gaps and suggest better dietary advice for this gro…

This study tests a new imaging system that uses a fluorescent dye and artificial intelligence during colonoscopy to measure how leaky the gut lining is in people with inflammatory bowel disease (IBD). It includes 70 adults (60 with IBD and 10 without) at three Canadian hospitals.…

This study will collect information from 2,000 adults having colorectal surgery with the Hugo RAS robot. Researchers will track complications, recovery, and long-term outcomes to see how safe and effective the system is. The goal is to provide real-world evidence to improve minim…

This study follows 50 adults with ulcerative colitis who are already seeing a naturopathic doctor. Over 12 weeks, researchers track symptom changes using questionnaires. The goal is to gather early information on how naturopathic care may help, without changing anyone's usual tre…

This study looks at how weight and body mass index (BMI) change in people with inflammatory bowel disease (IBD) who are treated with biologic drugs. Researchers will track weight monthly and see if higher BMI leads to higher drug doses and costs. The goal is to understand the fin…

This study looks at how common muscle loss (sarcopenia) is in people with inflammatory bowel disease (IBD) using CT scans. Researchers want to see if muscle loss changes how well biologic treatments work. About 50 adults with IBD who have received biologic therapy will take part.

People with inflammatory bowel disease (IBD) have a higher risk of colon cancer and need regular colonoscopies. This study compares two advanced methods: one uses a dye spray to highlight abnormal areas, and the other uses built-in camera filters to enhance the view without dye. …

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study tests a new questionnaire called PET (Patient Experience in Telehealth) to see if it accurately measures how patients feel about telemedicine visits. Researchers will ask 200 adults who had a telemedicine appointment at an Italian hospital to fill out the survey. The g…

This study will follow 83 adults with inflammatory bowel disease (IBD) at Assiut University Hospitals in Egypt to see if anemia can predict worse outcomes like hospitalizations. Anemia is common in IBD, but its role as a predictor is not well studied in this population. Researche…

This study looks at how obesity influences treatment response in 120 adults with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will track whether obese patients respond differently to standard therapies, especially biologics. The …

This study tests whether fluorescent dyes attached to two IBD drugs (adalimumab and risankizumab) can show where the drugs go in the gut. 30 adults with ulcerative colitis or Crohn's disease will receive a low dose of the labelled drugs, then undergo a special camera procedure 2-…

This study will check if certain blood cell measurements (platelet count, size, and shape) are linked to how active inflammatory bowel disease (IBD) is. Researchers will compare these blood test results with standard disease activity scores in 84 adults with IBD. The goal is to s…

This study will check how common Helicobacter pylori infection is in 100 adults with inflammatory bowel disease (Crohn's or colitis) at the Guadeloupe hospital. Researchers will take extra stomach biopsies during routine endoscopy to study the stomach's bacteria. The goal is to s…

This study will measure vitamin D levels in 100 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) to see if low vitamin D is linked to more active disease. Participants will have blood tests for vitamin D and inflammation markers. The goal is to better unders…

This study will check 44 children and teens with inflammatory bowel disease (IBD) for brain, nerve, and psychiatric issues like headaches, seizures, and ADHD. The goal is to catch these problems early to prevent long-term complications. Researchers will screen participants at Ass…

This study looks at the viruses (called bacteriophages) living in the guts of people with inflammatory bowel disease (IBD) and healthy people. Researchers want to understand how these viruses differ and whether they can be grown in a lab to create a new treatment. The study invol…

This study compares a newer imaging method called TXI with standard dye-based imaging during colonoscopies in people with inflammatory bowel disease (IBD). The goal is to see which method better detects precancerous changes that can lead to bowel cancer. About 242 adults with IBD…

This study will use musculoskeletal ultrasound to look for hidden joint, muscle, and tendon inflammation in 81 people with inflammatory bowel disease (IBD) who have no known arthritis. The goal is to see how common these hidden problems are and to develop a standard ultrasound ch…

This study will use a detailed heart ultrasound technique called speckle tracking to look for early signs of heart trouble in 100 adults with inflammatory bowel disease (IBD). Researchers want to see if this method can catch heart changes before they become serious and how those …

This study looks at whether taking a daily vitamin D supplement (2000 IU) for 12 months can improve the health and quality of life of people with Crohn's disease or ulcerative colitis. Researchers will track how well participants stick to the supplement and measure their vitamin …

This observational study will follow 4500 adults with Crohn's disease or ulcerative colitis to identify biological markers—such as gut bacteria patterns—that predict disease progression and complications. Researchers will collect blood, stool, saliva, and tissue samples during ro…

This study tests whether data from a wearable device and grocery loyalty cards can help detect disease flares in people with Crohn's disease or ulcerative colitis. Eighty adults will wear a smartwatch and use a store card to track their health and food purchases. The goal is to d…

This study uses computer simulations to better understand how a subcutaneous (under-the-skin) form of the drug infliximab works in people with inflammatory bowel disease (IBD) and rheumatoid arthritis. Researchers will analyze data from previous trials to create a model that pred…