Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a simple infusion after bowel surgery cut opioid use and speed recovery?

NCT ID NCT07434310

Symptom relief Sponsor: Dr. Naveed Siddiqui Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving a drug called dexmedetomidine for 48 hours after laparoscopic bowel surgery helps patients recover better. About 70 adults will receive either the drug or a placebo, and neither they nor their doctors will know which. The main goal is to see if the drug improves overall recovery, reduces pain, and lowers the need for strong opioids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine
What this could lead to
If it works, this could provide a safer, non-opioid way to manage pain after bowel surgery, leading to faster recovery and fewer side effects.
What could go wrong
This is a small, single-center trial. The drug may not improve recovery more than placebo, and it can cause low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 18-70 years. 2. Undergoing elective or semi-elective laparoscopic-assisted bowel surgery (e.g., bowel resection, colectomy, ileostomy reversal). 3. ASA physical status I-III. Exclusion Criteria: 1. Known allergy or hypersensitivity to dexmedetomidine. 2. Cardiac impairment defined as: 1. Moderate or severe systolic dysfunction 2. Moderate or severe valvulopathy (as per American Society of Echocardiography criteria) 3. Significant bradycardia (baseline heart rate \< 60) or 4. Heart block without a pacemaker. 3. Active infection or sepsis at the time of surgery. 4. Use of medications with significant interactions with dexmedetomidine (e.g., MAO inhibitors). 5. Pregnant or breastfeeding individuals. 6. Current opioid use (\> 30 mg daily oral morphine equivalent) or history of opioid use disorder. 7. Current clonidine use. 8. Patients undergoing thoracic epidurals. 9. Patients with liver impairment with a Child-Pugh class of B (moderate) or C (severe).

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Bowel diseases, inflammatory are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Abdominal Pain inflammatory bowel disease Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bowel diseases, inflammatory Bowel surgery Laparoscopic abdominal surgeries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mount Sinai Hospital

    Toronto, Ontario, M5G 1X5, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.