Childhood malignant neoplasm

This trial investigates how well routine childhood vaccines work in children who have recently finished chemotherapy for cancer. The goal is to see if revaccination can restore protective immunity against diseases like measles, mumps, and whooping cough. Participants receive a se…

This early-phase trial tested whether giving activated natural killer (NK) cells, with or without a protein called rhIL15, is safe and feasible for children and young adults with solid tumors that didn't respond to other treatments. Sixteen participants received chemotherapy to l…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tested a drug called avapritinib in 29 children aged 2 to 18 with advanced solid tumors that have specific genetic changes (KIT or PDGFRA). The goal was to see if the drug is safe and can shrink or control the tumors. Participants took the drug by mouth, and researcher…

This study looked at whether a 3-month aerobic exercise program could improve heart function in 47 childhood cancer survivors who had been treated with anthracycline chemotherapy. Participants chose their own exercise and received support at a YMCA. The goal was to see if exercis…

This study tested whether eating only during an 8-hour window each day (time-restricted eating) helps young adult survivors of childhood cancer manage their weight. Thirteen survivors participated to see if this approach is safe, doable, and acceptable. The goal is to reduce obes…

Nearly 60% of children with cancer become malnourished, which can lead to infections and worse outcomes. This pilot study tested three nutrition approaches—oral supplements, appetite-stimulating drugs, and tube feeding—in 19 children to see which best improved body composition an…

This study explores whether a heart ultrasound taken during exercise on a special bicycle can detect subtle heart changes in young people who finished cancer treatment months or years earlier. It aims to see if this test is practical and acceptable for survivors aged 10 to 25, an…

Parents of children with complex medical conditions often feel unsure about managing their child's symptoms at home. This trial tests whether a mobile app with nurse support can help. Ninety-six parents receive either the app, which offers health checks, monitoring, education, an…

Researchers are testing a digital picture-based tool that lets children with cancer report symptoms and distress during high-dose methotrexate treatment. The study includes children aged 5 to 17, their guardians, and healthcare professionals. Children use the tool to rate distres…

This trial tests whether an augmented reality (AR) app-based cognitive behavioral therapy (CBT) program can help children aged 6 to 12 who are undergoing chemotherapy for cancer cope with treatment-related distress and improve their quality of life. Participants are randomly assi…

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This study tested three non-drug methods to reduce pain, fear, and anxiety during subcutaneous injections in 45 children aged 6–12 with cancer. The approaches were Buzzy® (a device that vibrates and cools the skin), a cognitive-behavioral coaching package, and a kaleidoscope for …

This study looked at whether visits from specially trained therapy dogs could reduce distress and anxiety in children aged 5-17 who were hospitalized for cancer treatment. The researchers also checked if the visits increased germs on the children's hands, even with hand sanitizin…

This study tested a preventive skin care routine in 14 children (ages 6 months to 18 years) with brain tumors who were receiving targeted therapy (BRAF, MEK, or Pan-RAF inhibitors). The goal was to see if gentle skin care and sun protection could reduce or prevent skin reactions …

This phase 3 trial tested whether giving a continuous, slow infusion of ondansetron (a common anti-nausea drug) plus dexamethasone (a steroid) could better control nausea and vomiting in children undergoing chemotherapy. The study enrolled 28 children aged 1 day to 18 years with …

This study tested whether a parent-child mandala painting activity during chemotherapy could reduce fear and pain in children with cancer and ease the burden on their caregivers. 108 children aged 5-12 and their parents took part, with half doing six 30-minute painting sessions o…

This study looked at whether giving diet advice and a simple exercise program could improve nutrition and reduce muscle loss in children aged 5-18 with cancer. 104 children took part, with half receiving the diet and exercise plan for three months while the other half waited. The…

This study tested a 5-week online program that teaches parents of children with cancer how to use structured play to support their child's emotional needs. 60 parents took part, with half receiving the program and half not. The goal was to see if the program helps parents feel mo…

This study tested a personalized exercise plan delivered at home via telehealth for childhood cancer survivors who have trouble exercising due to past treatment. 181 survivors took part to see if the program could improve their exercise capacity, heart and lung function, and qual…

This study tested whether playing virtual reality games focused on exercise and mindfulness could help children with cancer be more active and feel better. Eleven kids participated in an 8-week program either right away or after a wait. Researchers measured steps per day and over…

This study looked at whether a gentle exercise program called Gyrokinesis could help reduce cancer-related fatigue in children and teens who had been treated for a brain tumor. 80 participants who had finished active treatment at least a year earlier took part. The study measured…

This phase II trial tested an interactive movie system called PROMISE to help children aged 3-11 stay still during radiation therapy for cancer, aiming to reduce the need for general anesthesia. The study enrolled 30 children and compared the rate of anesthesia use to a historica…

This study tested a telehealth program called CC LinksTele that provides one-on-one coaching to help cancer survivors and their caregivers manage financial and legal issues related to cancer care. 124 adult patients and caregivers from a pediatric cancer clinic took part. The goa…

This study tested a personalized exercise program for children aged 5 to 17 with advanced cancer that cannot be cured. The program included walking on a treadmill and muscle-strengthening exercises, with the goal of seeing if it is safe and tolerable. Only 4 children took part, a…

This study tested whether a personalized exercise program could help children and teens undergoing cancer treatment feel less tired and improve their quality of life. Nearly 500 participants did age-appropriate exercises like strength, balance, and endurance training for 30–60 mi…

This study tested whether a hybrid (in-person and online) physiotherapy program is feasible for children aged 4-17 with acute lymphoblastic leukemia. Ten children and their parents tried the program, which included tailored exercises and games. The goal was to see if families cou…

This study tested a 12-week mobile phone program of daily reflection and meditation exercises for children with cancer and their families. The goal was to see if the program is practical and helpful for improving mental well-being and reducing anxiety and depression. Forty partic…

This study looked at whether a mobile cognitive behavioral therapy (CBT) program, combined with a gentle brain stimulation technique called tDCS, could help teens who survived bone cancer manage chronic pain. Researchers first adapted the program for Black and Hispanic teens, the…

This study tested a smartphone app designed to help young cancer survivors (ages 15-29) manage anxiety. The app uses attention bias modification (ABM) to retrain how the brain reacts to stressful triggers, along with gratitude exercises. The goal was to see if survivors would use…

This study tested an online insomnia treatment program for adult survivors of childhood cancer. Over 1,500 survivors participated, using a web-based program that teaches healthy sleep habits and cognitive behavioral techniques. The goal was to see if improving sleep could also bo…

This study tested a simple, drug-free method called WASPE to help children aged 0-4 years stay still during radiation therapy for cancer. The method uses activities like watching videos, playing, and eating snacks to keep the child awake and calm. 48 children took part, and the g…

This study tested a mobile app designed to help children aged 9 to 16 who recently finished cancer treatment manage their symptoms. The app also provides support for their caregivers. The goal was to see if the app is easy to use and helpful for symptom relief.

This study tested a culturally relevant program to help Spanish-speaking Latino caregivers of children with cancer feel less stressed and improve their quality of life. 33 caregivers took part, and the program focused on reducing anxiety and depression. The goal was to see if thi…

This study tested a web-based program to help children aged 8-17 with cancer adjust to returning to school. The program included modules for children, parents, teachers, and peers, focusing on communication, coping, and social skills. Twenty children participated, and researchers…

This study tested whether having children with cancer report their symptoms three times a week using a web-based tool (SPARK) could improve their quality of life. The tool alerted healthcare providers and linked to care pathways for managing symptoms. A total of 445 children aged…

Researchers compare children with cancer and healthy children to see how pain sensitivity, body composition, and physical activity differ. The study also looks at how parents respond to their child's pain. About 60 children aged 8 to 18 and their parents take part. The goal is to…

This study tests whether a training program for pediatric oncology nurses improves their knowledge and infection prevention behaviors when caring for central venous catheters (CVCs). Thirty nurses will receive education including a presentation, video, and hands-on practice. Thei…

This study looked at whether offering genetic counseling by phone or video could help more childhood cancer survivors get genetic testing. About 391 survivors took part, comparing remote counseling to usual care. The goal was to see if remote services increase testing uptake and …

This pilot trial explores whether using a tumor's molecular profile—its gene expression and DNA sequencing—can help doctors choose a personalized treatment plan for children and young adults with high-grade glioma (a type of brain cancer). Participants receive a recommendation fr…

This study looked at how cancer and its treatment affect thinking, memory, emotions, and behavior in children and teens. Researchers collected information from tests and surveys over time to understand these effects. The goal was to learn more, not to test a new treatment.

This study looked at nearly 4,000 childhood cancer survivors to see if their genes affect their risk of developing serious late complications like heart failure, stroke, bone damage, or a second cancer. Researchers compared survivors who had these problems with those who did not,…

This study looked at whether children and teens who had a stem cell transplant for leukemia could use an iPad-based brain-training program. The main goal was to see if the program was practical and if kids would stick with it. Only 17 participants were enrolled, and the study foc…

This study tested whether a detailed genetic analysis of tumor tissue could find treatment targets in 80 children with recurrent or very high-risk brain tumors. The goal was to see if this approach is practical and can help doctors choose personalized therapies. No new drugs were…

This study looked at children and young adults under 24 who had COVID-19, including those with cancer. Researchers collected samples and medical information to learn about symptoms, risk factors, and how the virus spreads. The goal was to better understand the disease in younger …

This study tested a simple way for adult survivors of childhood cancer to get their hearing checked. Instead of going to a hospital, participants took a hearing test at a local hearing aid shop. The goal was to see if this approach could help more survivors find out if they have …

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…

This study looked at whether analyzing the DNA and RNA of children's relapsed or treatment-resistant tumors can help doctors pick targeted therapies. Researchers profiled tumors from 791 children and adolescents using advanced genetic sequencing. The goal was to see how many pati…

This study looked at whether a 6-week breathing muscle training program is possible for childhood cancer survivors and how it affects their breathing during exercise. Seven survivors who finished cancer treatment at least a year ago took part. The goal was to see if they could st…

This study looked at whether health questionnaires filled out by childhood cancer survivors and their parents match what doctors find during check-ups. About 300 survivors aged 8 to 18 took part, completing surveys over three years. The goal is to make these questionnaires more a…

This study looked at 32 childhood cancer survivors who had pelvic radiation at least one year earlier. Researchers measured bladder function and bone density to understand long-term side effects. The goal was to gather knowledge, not to test a new treatment.

This study looked at how to gather information about complementary therapies (like massage, yoga, or acupuncture) for children with cancer. Researchers worked with 100 kids to see if it's possible to measure things like pain, nausea, and quality of life during these treatments. T…

This completed study looked at 80 childhood cancer survivors who had received high doses of anthracycline chemotherapy. Researchers used cardiac MRI and blood tests to find early signs of heart damage that standard tests might miss. The goal was to see if these advanced methods c…

This study tested a chatbot named Penny that sends text messages to help adult survivors of childhood or young adult cancers schedule follow-up appointments, lab work, and scans. The goal was to see if survivors who had not been to a clinic in over three years would use the chatb…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This observational study checked whether children with hepatitis C who also have thalassemia or survived childhood cancer are more likely to develop insulin resistance (a step toward diabetes). Researchers compared 90 infected children to healthy kids of the same age and gender. …

This study aimed to create a communication tool to help doctors and patients discuss when cancer stops responding to treatment. Researchers interviewed 128 people, including patients with certain breast cancers, metastatic uveal melanoma, parents of children with cancer, and heal…

This study looked back at medical records of 91 children who had a malignant bone tumor removed from their leg and then had the bone rebuilt using one of three techniques: induced membrane, vascularized fibula, or vascularized fibula plus a bone graft. The goal was to compare how…

This study looked at how radiation therapy for pediatric brain cancer affects memory and brain structure in children, teens, and young adults. Researchers used MRI scans and memory tests to compare 60 participants. The goal is to better understand which brain areas are harmed by …