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Simple skin care may shield kids from cancer drug side effects

NCT ID NCT04479514

Symptom relief Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a preventive skin care routine in 14 children (ages 6 months to 18 years) with brain tumors who were receiving targeted therapy (BRAF, MEK, or Pan-RAF inhibitors). The goal was to see if gentle skin care and sun protection could reduce or prevent skin reactions caused by these drugs. The approach included daily moisturizing, sun avoidance, and mild cleansers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

14 people

The number who actually took part.

Started

Oct 2020

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 months to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with a brain tumor between ages 6 months old -18 years old and will undergo treatment with at least one of the following: 1. Targeted BRAF inhibitor therapy to treat the brain tumor 2. Targeted MEK inhibitor therapy to treat the brain tumor 3. Targeted pan-RAF inhibitor therapy to treat the brain tumor * Subjects may participate in other studies, including therapeutic trials. * Ability to comply with PSCR including sun protection, gentle skin care and every other day dilute bleach baths. * Ability to understand and/or the willingness of their parent or legally authorized representative to sign a written informed consent document. Exclusion Criteria: * Diagnosed with brain tumor at \> 18 years old * No data in medical records regarding treatment exposures * Treated with a BRAF, MEK or pan-RAF inhibitor in the last three months * Past or present allergic reaction to bleach * Past or present allergic reactions to sunscreen and/or creams, lotions, emollients to be utilized in this study

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Conditions

The condition(s) this trial relates to.

brain neoplasm central nervous system cancer central nervous system neoplasm childhood malignant neoplasm childhood neoplasm dermatitis neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CNS tumor, childhood Pediatric cancer Skin inflammation

Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.