Carotid stenosis

This study compares two methods to protect the brain during a procedure to open a narrowed neck artery (carotid stenting). The standard method uses a small filter to catch debris, but some particles may still reach the brain. The new method adds a balloon that temporarily stops b…

This trial tests whether placing a stent in a narrowed or blocked neck artery during emergency stroke treatment helps people recover better than just removing the clot in the brain. About 15-20% of severe strokes involve both a brain clot and a neck artery blockage. The study wil…

This study compares two approaches for people with mild-to-moderate carotid artery stenosis (narrowing of the neck arteries): a standard statin regimen versus a statin plus a PCSK9 inhibitor (evolocumab) given as biweekly injections. The main goal is to see whether the combinatio…

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in the carotid arteries of the neck before placing a stent. About 185 people with heavily calcified carotid arteries will be enrolled. The main goal is to see if the procedure is s…

This study looks at how long people at high risk of bleeding should take two blood thinners after having a carotid artery stent placed. About 1,556 participants will first take both aspirin and clopidogrel for 30 days, then be split into two groups: one continues both drugs for 1…

This study looks at people with narrowed carotid arteries who are getting a stent. Some people do not respond well to the common blood thinner clopidogrel. The study compares giving these 'non-responders' a different drug, ticagrelor, versus continuing clopidogrel in those who re…

This study tests whether breathing in a safe, inexpensive gas called argon during carotid artery surgery can prevent brain damage and confusion after the operation. About 100 adults having elective carotid surgery will be randomly assigned to receive either argon gas or a placebo…

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study compares two drugs, choline fenofibrate and policosanol, in 56 Korean adults with type 2 diabetes and high cholesterol who have early signs of artery plaque. The goal is to see if choline fenofibrate can reduce plaque buildup in the carotid artery, measured by 3D ultra…

This study compares two medications, clopidogrel and cilostazol, to see if they can slow down the buildup of plaque in the neck arteries of people with type 2 diabetes. The goal is to prevent future heart attacks and strokes. About 120 adults with diabetes and early signs of arte…

This study looks at whether adding omega-3 to a common statin (atorvastatin) can better reduce plaque buildup in the neck arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to get either atorvastatin plus omega-3 or atorvastat…

This study is testing a new stent system to treat narrowed carotid arteries (the main arteries in your neck) in people who are at high risk for standard surgery. The goal is to see if the stent is safe and effective at preventing strokes, heart attacks, and death. About 212 parti…

This study tests whether using a blood pressure cuff on the arms—inflating and deflating it in cycles—can protect the brain and heart after carotid artery stenting. 300 people with narrowed neck arteries who have had a recent stroke or mini-stroke will be randomly assigned to get…

This study tests whether using ultrasound (TCD) during and after carotid artery stenting can reduce small brain injuries caused by clots. About 232 people with severe carotid artery narrowing will be randomly assigned to receive stenting with or without TCD. The goal is to see if…

This study tests whether performing carotid artery surgery within 72 hours of a mini-stroke or minor stroke is safer and more effective than waiting 4 to 15 days. About 456 participants with a blocked neck artery will be randomly assigned to one of two timing groups. The goal is …

This study compares a stent (CARESTO® heal) plus standard medication against medication alone in 536 people who recently had a stroke or retinal artery blockage due to a specific type of carotid artery disease that is not severely narrowed. The goal is to see if the stent can low…

This registry will follow 8,000 people with severe carotid artery disease who receive a stent to open the blocked artery. The main goal is to track how many have a stroke or die within 30 days of the procedure. The results will help select skilled doctors for a larger randomized …

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to s…

This study tests whether monitoring the brain's oxygen levels during carotid artery surgery can help doctors manage blood pressure and reduce the risk of stroke. 560 adults scheduled for surgery will be randomly assigned to standard care or a strategy that uses a brain oxygen ind…

This study compares two types of CT scans for imaging the buildup of plaque in the carotid arteries, which supply blood to the brain. The newer photon-counting detector CT (PCD-CTA) will be compared with the standard energy-integrating detector CT (EID-CTA) in 100 people with car…

This study looks at 200 adults who have had an ischemic stroke or transient ischemic attack (TIA). Each participant will receive two types of imaging: a non-contrast magnetic resonance angiography (NC-MRA) and a carotid Doppler ultrasound. The goal is to see how well these two me…

This study tests whether a quick, routine ultrasound measurement (called the resistance index) can accurately identify people with narrowed neck arteries who have normal brain blood flow response. If it works, many patients could avoid a time-consuming, specialized test. The stud…

This study tests a new 3D ultrasound probe to see tiny blood vessels inside fatty plaques in the neck arteries. These vessels can make plaques more likely to rupture and cause a stroke. Ten people who already had a standard ultrasound will get this new 3D scan with a contrast dye…

This study tests whether a special PET/MR scan can tell which fatty deposits in the neck arteries are likely to cause a stroke. About 100 adults with known carotid plaque will get two types of PET tracers along with MRI to measure inflammation and scarring inside the plaque. Rese…

The CEST trial compares two timings for carotid revascularization, a procedure that clears a narrowed neck artery to prevent another stroke. It enrolls adults who have had recent stroke symptoms and an MRI-confirmed small area of brain injury in the territory of that artery. Part…

This study looks at whether a supervised exercise program can improve balance and mobility in older adults who have moderate narrowing of the carotid artery (50-69% blockage) but no stroke symptoms. About 50 participants will do aerobic and balance exercises to see if their walki…

This study aims to find early warning signs for major chronic diseases like stroke, heart disease, and cancer by following 4,500 healthy adults aged 30-80 in Lishui. Participants will receive regular check-ups and long-term monitoring. The goal is to improve prevention and care a…

This study collects blood and tissue samples from 200 people with any degree of carotid artery narrowing who are already scheduled for a procedure. Researchers aim to learn more about the features of plaque that may increase stroke risk. No extra treatments or tests are involved …

This study looks at whether menopause and HIV together increase heart disease risk in women. Researchers will examine inflammation and body fat using MRI scans and blood tests in 90 women with HIV. The goal is to understand why heart risks may worsen after menopause in this group…

This study looks at whether bacteria in your mouth can influence the buildup of fatty plaques in the neck arteries that supply blood to the brain. Researchers will collect samples from 200 adults having surgery to remove these plaques and compare the bacteria found in the mouth, …

This study is testing several advanced imaging techniques to see if they can better predict which people with narrowed carotid arteries are at risk of a stroke. Researchers will compare 45 people who have already had a stroke with 105 who have not, using ultrasound and MRI to exa…

This study is testing whether a new type of PET-MR scan can help predict stroke risk in people with significant narrowing of the carotid artery (the main artery in the neck) who have not yet had symptoms. Researchers will give participants an injection of a radioactive tracer and…

This study looks at 60 people having awake surgery to clear a blocked neck artery (carotid endarterectomy). During the procedure, the surgeon temporarily clamps the artery, which can reduce blood flow to the brain. Researchers will compare two ways to monitor brain blood supply: …

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study is testing whether a deep learning model can predict cerebral hyperperfusion syndrome (CHS), a rare but serious brain complication that can occur after carotid artery surgery. Researchers will enroll 500 adults aged 30-80 who are having carotid revascularization. The g…

This study is testing a new type of CT scan (photon counting/spectral CT) to see if it can better identify the makeup of plaque in the carotid arteries of people who have had a stroke. Researchers will compare the CT results with MRI scans and, in some cases, with actual plaque t…

This study tests whether a non-invasive digital cuff can accurately measure blood pressure continuously during carotid endarterectomy surgery, compared to the standard invasive arterial catheter. The goal is to see if the cuff can provide the same vital information without the ri…