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New CT scanner could spot hidden stroke risks in neck arteries

NCT ID NCT05764772

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new type of CT scan (photon counting/spectral CT) to see if it can better identify the makeup of plaque in the carotid arteries of people who have had a stroke. Researchers will compare the CT results with MRI scans and, in some cases, with actual plaque tissue removed during surgery. The goal is to see if this advanced CT can reliably tell apart calcium, hemorrhage, and fatty deposits in the plaque, which could help doctors assess stroke risk more accurately.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a more accurate, non-invasive way to identify dangerous plaque in stroke patients, helping guide treatment decisions.
What could go wrong
This is a small, early observational study (70 people) that only tests the imaging method, not a treatment. The new CT may not prove better than existing scans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients presenting with acute stroke or transient ischemic attacks and stenosis of the ipsilateral carotid artery will be identified and eligible patients will be screened and consented for study participation in a multi-disciplinary effort by Vascular Neurology (contact: Dr. Brett Cucchiara), Vascular Surgery (contact: Dr. Grace Wang), and Diagnostic Radiology (contact: Dr. Jae W. Song).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with symptomatic carotid stenosis with ipsilateral ischemic infarcts attributable to the carotid disease * At least 1mm of noncalcified plaque on same side of stroke * Brain MRI documenting ischemic infarct in distribution attributable to ipsilateral carotid disease * Patients planned to undergo carotid endarterectomies * Patients must be able to read and understand English * Participants must sign the informed consent form Exclusion Criteria: * Exclusion Criteria * Patients less than 18 years old * Women who are pregnant and/or nursing

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Conditions

The condition(s) this trial relates to.

carotid stenosis ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid plaque

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Pennsylvania Hospital

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

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