Could a simple arm cuff cut stroke risk after artery surgery?
NCT ID NCT07412249
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether using a blood pressure cuff on the arms—inflating and deflating it in cycles—can protect the brain and heart after carotid artery stenting. 300 people with narrowed neck arteries who have had a recent stroke or mini-stroke will be randomly assigned to get the cuff treatment plus stenting or stenting alone. The goal is to see if the cuff reduces the chance of another stroke, heart attack, or death over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- remote ischemic conditioning (blood pressure cuff inflation on arms)
- What this could lead to
- If it works, this could offer a simple, non-drug way to lower the risk of stroke and heart attack after carotid artery stenting.
- What could go wrong
- This is a single-center study with 300 participants, so results may not apply broadly. The treatment is experimental and long-term benefits are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 40 years old; * Patients with symptomatic moderate to severe stenosis of the internal carotid artery; * History of ipsilateral cerebral ischemic symptoms within the past 180 days; * Planned for carotid artery stent; * Essen Score ≥ 3; * Modified Rankin Scale score of 0 or 1; * Signed informed consent. Exclusion Criteria: * Uncontrolled severe hypertension (systolic blood pressure \> 180 mmHg or diastolic blood pressure \> 110 mmHg despite medication) * Subclavian artery stenosis ≥ 50% or presence of subclavian steal syndrome * Severe hematological disorders or significant coagulation abnormalities * Contraindications to remote ischemic conditioning, such as severe soft tissue injury, fracture, or vascular injury in the upper limbs, or peripheral vascular disease in the distal upper limbs * Severe comorbid conditions with a life expectancy of less than 1 year * Participation in another clinical trial within the past 3 months or ongoing participation * Any other circumstances deemed by the investigator as unsuitable for participation in this clinical study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of Neurology, General Hospital of Northern Theater Command
RECRUITINGShenyang, 110016, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Ultrasound technique aims to spot Stroke-Prone plaque
- Can a forehead light sensor spot hidden brain oxygen drops during carotid surgery?
- Could a stent double the chance of a good recovery after severe stroke?
- Personalizing blood thinners after carotid stenting could prevent heart attacks and strokes
- New PET tracer aims to reveal hidden immune activity in tumors and arteries