Cardiac rhythm disease

This study is testing a new, wire-free pacemaker called LivIQ in 325 people who need a pacemaker for a slow heartbeat. The goal is to see if it is safe and works well to keep the heart beating at the right pace. Participants will be followed for several months to check the device…

Researchers compare two procedures for people with persistent atrial fibrillation that has not responded to at least one antiarrhythmic drug. One group receives standard catheter ablation, which burns or freezes small areas inside the heart. The other receives a hybrid procedure …

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This trial investigates whether a new dual energy catheter system can safely and effectively treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. The system uses both radiofrequency and pulsed field energy to ablate the heart tissue causing the probl…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study tests whether a filter device called the Sentinel Cerebral Protection System can prevent stroke and brain injury during ablation for atrial fibrillation (an irregular heartbeat). The device is placed in the arteries to catch debris that might break loose during the pro…

This study is testing a new type of pacemaker that doesn't use wires (leads) to help control slow heart rhythms. About 20 adults who need a pacemaker will get this device and be checked for safety and how well it works at 1 and 3 months. The goal is to see if this leadless system…

This study tests whether destroying small areas of heart muscle that cause dangerous rhythms (ventricular tachycardia ablation) during LVAD implant surgery can reduce the number of these rhythms after surgery. About 100 adults with advanced heart failure who are getting an LVAD w…

This study will test the safety and performance of a new generation of implantable heart devices called CorSky ICDs and CRT-Ds. These devices help control dangerous heart rhythms in people with heart failure or tachyarrhythmia. About 151 participants will be implanted with the de…

This study tests whether a pacemaker plus a heart ablation procedure is better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. Participants will either get a pacemaker implant and ablation, or continue with optim…

This study will test an AI software called Volta AF-Xplorer II during catheter ablation for atrial fibrillation. About 150 adults will be treated in real-world clinics, and researchers will track how well the AI helps guide the procedure. The goal is to see if the AI improves saf…

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study looks at people with heart devices that detect short bursts of irregular heartbeats (atrial high-rate episodes lasting 6 minutes to 24 hours) but no diagnosed atrial fibrillation. It tests whether starting rhythm-control drugs early, along with managing heart risk fact…

This early study tests a new device that uses a special wire with radiofrequency energy to safely cross the wall between the heart's upper chambers. This step is needed for procedures that treat heart rhythm problems or close the left atrial appendage. The study will enroll 60 ad…

This study follows 1,805 people who already have an Aveir DR leadless pacemaker to see how safe it is over 5 years. The pacemaker helps control slow heart rhythms without wires. Researchers will track complications shortly after implant and for years afterward using real-world da…

This study tests a new device called MAGiC that uses magnets to help doctors treat abnormal heart rhythms. About 150 adults who need a standard heart ablation procedure will take part. The goal is to see if the device is safe and works well, both right after the procedure and ove…

This study compares two approaches for treating atrial tachycardia that occurs after atrial fibrillation ablation or heart surgery. One group gets standard ablation targeting all abnormal heart circuits, while the other gets a more focused ablation guided by a new ultra-high-dens…

This study tests a new device (TS-RF system) that uses radiofrequency energy to help doctors safely reach the left side of the heart during procedures for abnormal heart rhythms or mitral stenosis. About 70 adults will be randomly assigned to receive either the new device or a st…

This study tests whether colchicine, a common anti-inflammatory drug, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive either colchicine or a placebo to see if it prevents worsening heart failur…

This study tests whether heart failure patients who fully recover after treatment for a fast heart rhythm (like atrial fibrillation) can safely stop their heart failure medications. 348 participants will be randomly assigned to either gradually stop their drugs or continue them a…

This study compares a single dose of targeted radiation (SBRT) to the standard catheter ablation procedure for reducing dangerous heart rhythms in people with advanced heart disease. Sixty participants will be randomly assigned to one of the two treatments. The main goal is to se…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests a single, high-dose radiation treatment aimed at the area of the heart causing dangerous rapid rhythms (ventricular tachycardia). It includes 12 adults with an implanted defibrillator who have not been helped by medications or standard procedures. The goal is to …

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This trial tests whether an artificial intelligence tool can help doctors detect undiagnosed atrial fibrillation and structural heart disease from routine electrocardiograms (ECGs). About 1,000 healthcare providers are randomly assigned to either receive AI-generated risk alerts …

This study evaluates a new multichannel ECG system designed to detect early signs of cardiovascular disease (CVD) in people who may have no symptoms yet. The system uses advanced algorithms to analyze electrical signals from the heart, looking for subtle abnormalities that could …

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study tests whether wearing a portable ECG monitor for 30 days after a heart valve replacement (TAVI) can detect dangerous heart rhythm problems better than the usual 1-2 days of hospital monitoring. 250 patients will be randomly assigned to either the extended monitoring gr…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study tests whether an artificial intelligence (AI) system can help doctors spot hidden atrial fibrillation (AF) — a common heart rhythm disorder that raises stroke risk — by flagging suspicious electrocardiograms (ECGs). About 14,700 patients will be randomly assigned to ha…

This Stanford study is testing computer algorithms to better map the heart's electrical activity in people with atrial fibrillation (AF), a common heart rhythm disorder. Researchers will compare different methods to see which best identifies problem areas in the heart. The study …

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This study tests whether adding lidocaine to the Custodiol solution used during heart bypass surgery can reduce dangerous heart rhythms that often occur after the heart is restarted. About 70 adults having planned coronary bypass surgery will be randomly assigned to receive eithe…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms like palpitations and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a dig…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether a special mapping catheter (Optrell) can better locate and treat heart rhythm problems coming from the papillary muscles, which are small muscle bumps inside the heart. About 20 adults with frequent or bothersome premature ventricular contractions (PVCs) …

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

Researchers are studying people with arrhythmia-induced cardiomyopathy, a condition where a fast or irregular heartbeat weakens the heart muscle. The study checks whether these patients carry more harmful gene variants than people with other types of cardiomyopathy or the general…

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…

This study is observing 4,500 people who need pacemakers or similar heart devices. The goal is to create a tool that predicts who is at risk of developing a weakened heart from the device itself. By identifying high-risk patients early, doctors can choose better pacing methods to…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

Researchers at the Heart Center Bad Berka run a registry that collects data on adults treated for heart rhythm problems. The registry follows people who receive medication, procedures such as ablation, or implanted cardiac devices. It tracks how safe and effective these treatment…

This trial is testing a medical device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety in people. Participants will be monitored closely, but the device is not yet proven to treat or cure any condition.

This observational study will follow 8,000 people with irregular heartbeats (arrhythmias) who are scheduled for a standard catheter ablation procedure using Biosense Webster devices. Researchers will track safety issues and how well the procedure works in everyday hospital practi…

This study involves 100 adults with heart rhythm problems who are already scheduled for a standard heart mapping procedure. Researchers will test new software features on the mapping system to see how well they work. The goal is to gather feedback to improve future versions of th…

This study tests whether artificial intelligence can use continuous ECG data to predict and detect life-threatening heart arrhythmias in patients admitted with acute cardiac illness. Researchers will analyze stored ECG data from 3000 adult patients to see if AI models can forecas…

This trial tests whether a case-based collaborative learning program helps newly graduated intensive care nurses better recognize heart rhythm disturbances (arrhythmias) and improves their attitudes toward patient safety. Novice nurses with less than a year of experience in coron…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study monitors how long Medtronic heart devices (like pacemakers) last and how often they have problems. It includes up to 20,000 people who have or will get one of these devices. The goal is to collect real-world data to improve future device safety and performance.

This study watches people with blood cancers like CLL who take BTK inhibitors or venetoclax to see how these drugs affect heart rhythm. Researchers will use EKGs, stress tests, and heart monitors to track abnormal rhythms and sudden death risk. The goal is to better understand an…

This study will test how easy and reliable a new wearable patch (eWave) is for monitoring heart activity in everyday life. About 500 healthy adults will wear the patch for up to 7 days and use a smartphone app. The goal is to see how long the patch stays on and if any skin proble…

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This registry tracks 2,000 adults with congenital heart disease who are on the waiting list for a heart or heart-lung transplant. The goal is to understand why some patients get worse or die while waiting, while others improve enough to be removed from the list. By collecting dat…

This study is not testing a drug or treatment. Instead, researchers are using artificial intelligence to analyze electrocardiogram (ECG) data from over 127,000 people. The goal is to create computer models that can quickly and accurately predict life-threatening heart rhythm prob…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study is developing an AI system that tracks tumors and organs during radiation therapy without needing physical markers. Researchers will use existing patient data to train and test the AI. If it works, it could help doctors target radiation more accurately. The study invol…

This study watches 600 adults on a heart-lung machine (ECMO) for severe shock to see how often they develop heart rhythm problems like atrial fibrillation. It tracks complications and recovery times. The goal is to learn more, not to test a new treatment.

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study will implant a small heart monitor (loop recorder) in 20 young adults aged 18-60 who have a heart condition called mitral annular disjunction and mild or no symptoms. The goal is to detect hidden dangerous heart rhythms that could lead to sudden cardiac death. Particip…

This Stanford study looks at 200 people with persistent atrial fibrillation (AF) who are scheduled for ablation or Maze surgery. Researchers will map the heart's electrical activity to see if the size of organized areas predicts whether the procedure works. The goal is to better …

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…

This study looks at data from the HeartMate 3 heart pump to see if it can help predict problems like bleeding, infection, or frailty in people with advanced heart failure. Researchers will track 150 adults getting the pump and compare pump alarms and readings to their health over…

This study will follow 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Some were taking blood thinners when they had their stroke, others were not. Researchers want to understand why blood thinners fail in some patients, by looking at …

This Stanford study is testing whether machine learning can help predict which patients with atrial fibrillation will benefit from a heart ablation procedure. Researchers will collect data from 120 people undergoing ablation and use it to train an algorithm that forecasts success…

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …

This study will follow 10,000 people who come to a clinic in Davos, Switzerland for cardiac rehabilitation after a heart attack, surgery, or other heart problem. Researchers will collect health data, blood samples, and genetic information to understand what helps people recover b…

This study looks at how modern, minimally invasive lung cancer surgery affects the heart's electrical signals. Researchers will monitor 100 adults before, during, and after surgery to see if temporary changes occur. The goal is to better understand the heart stress caused by the …

This study aims to find the genes that cause inherited heart and muscle diseases like cardiomyopathy, arrhythmias, and muscular dystrophy. Researchers will collect blood samples from up to 2,000 patients and their families to look for genetic mutations. The goal is to better unde…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…