University Of Rochester

This study compares two common bone graft materials (freeze-dried bone allograft and collagen-enriched cow bone xenograft) used to preserve the jawbone after removing a front tooth. About 50 adults who need a tooth extraction and plan to get a dental implant will be randomly assi…

This study tests whether high-dose vitamin D can prevent bone loss in men aged 50+ with prostate cancer who are receiving hormone therapy (ADT). ADT can weaken bones, raising the risk of fractures. Researchers will give 240 participants either high-dose vitamin D or a placebo for…

This study tests whether adding a kidney nerve procedure (renal denervation) to the standard heart ablation can better control atrial fibrillation (AF) in people with persistent AF who have normal blood pressure or well-controlled high blood pressure. About 50 adults will be rand…

This study is for people with serious blood cancers, immune deficiencies, or genetic disorders who need a stem cell transplant. Researchers are using umbilical cord blood from unrelated donors to see how well the new cells take hold and rebuild healthy blood counts. The goal is t…

This study tests whether destroying small areas of heart tissue that cause abnormal rhythms (ablation) during LVAD implant surgery can reduce dangerous heart rhythms after surgery. About 100 adults with advanced heart failure who are getting an LVAD will be included. The goal is …

This study tests a program called TEACH-ER that helps children with asthma after they leave the emergency room. It includes easy-to-understand education, a video doctor visit within a week, and follow-up virtual coaching. The goal is to see if this support reduces the need for mo…

This study tests a combination of two drugs (neratinib and capecitabine) in people with breast cancer that has spread to the brain and is HER2-negative by standard tests but shows abnormal HER2 activity on a special test. The goal is to see if this treatment can help control the …

This study compares two common heart failure medications, carvedilol and metoprolol, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. The goal…

This study is testing whether a safe green dye, called indocyanine green (ICG), can help surgeons see if a child's cancer has spread to nearby lymph nodes. About 10 children with solid tumors will get the dye injected during surgery. The goal is to see if the dye makes the lymph …

This study tests whether a 10% iodine solution applied to teeth can prevent new cavities in children aged 2 to 6 who already have severe early childhood caries. About 202 children will receive either the iodine treatment or a placebo, along with standard fluoride varnish, every 3…

This study tests whether giving nurses and staff the authority to give the HPV vaccine without a doctor's order (called standing orders) can increase vaccination rates in 9-17 year-olds. About 16,000 patients from 40 medical practices in Western New York will take part. The goal …

This study tests a combined mobile exercise and cognitive training program for older adults (60+) who have finished cancer treatment and have memory or thinking concerns. The goal is to see if the program is practical and helps improve thinking skills. About 40 participants will …

This study tests the Thrive program, which helps young adults (ages 18-25) with fetal alcohol spectrum disorders (FASD) set personal goals and build social support. Participants are randomly assigned to start the program right away or after a delay, and then to individual or grou…

This study tests a program called SONATA that helps older adults (65+) with advanced cancer strengthen their social connections. Researchers want to see if it improves emotional, social, and overall quality of life. The study involves 70 participants and compares the program to s…

This study looks at whether combining exercise with cognitive rehabilitation can improve thinking and memory in older cancer survivors. Researchers will compare three approaches—exercise alone, brain training alone, or both together—against usual care. The goal is to see if these…

This study tests a program where older adults with advanced cancer and their caregivers talk about their lives together. The goal is to see if this approach is practical and helps improve emotional well-being and relationship quality. About 60 patient-caregiver pairs will be rand…

This study tests whether a supplement from seaweed called fucoidan can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 cancer survivors with ongoing fatigue will take the supplement for 8 weeks. The goal is to see if it's practical to s…

This study tests a 4-month coaching program called SONATA that helps older adults (age 60+) with advanced cancer build a support network of family and friends. The goal is to see if this social support improves treatment adherence and quality of life. About 330 participants will …

This study tests whether the My Health Coach app can improve quality of life and daily functioning for adults with fetal alcohol spectrum disorders (FASD). Two hundred adults with FASD will be split into two groups: one gets the app right away, the other waits 12 weeks. Everyone …

This study tests whether a mobile health exercise program can improve physical function, reduce fatigue, and enhance mood and quality of life in older adults (age 60+) with myeloid neoplasms who are receiving chemotherapy. About 170 participants will be randomly assigned to eithe…

This study looks at which parts of PTSD therapy work best for children aged 8-17 who have experienced a traumatic event. Researchers will compare different treatment components to a placebo to see what helps reduce symptoms. Participants attend weekly sessions and complete survey…

This study tests whether lisinopril, a blood pressure medicine, can reduce urinary problems caused by radiation for prostate cancer. About 30 men with non-spreading prostate cancer will take lisinopril during their radiation treatment. Researchers will track urinary symptoms and …

This study tests whether reducing loneliness can help people with opioid use disorder. 300 adults who feel lonely and use opioids will join 6 weekly sessions. Researchers will measure changes in loneliness and opioid use to see if this approach works.

This study looks at whether a non-invasive, acupuncture-like electrical treatment can help reduce dry mouth in people who had radiation for head and neck cancer. About 75 adults who completed radiation at least 3 months ago and still have dry mouth will receive the therapy over 1…

This study tests a remote education program called Tele-Savvy, adapted for Latino caregivers. It aims to help 64 Spanish-speaking adults who care for a loved one with Alzheimer's or dementia feel more capable and less stressed. Participants join weekly group sessions and watch vi…

This study looks at whether daily text message reminders to do pelvic floor exercises can help men recover bladder control faster after prostate surgery. About 132 men who are planning to have prostate surgery will be split into two groups: one group gets the text reminders, the …

This study tests a new way for doctors, patients with dementia, and their family caregivers to talk together about cancer treatment decisions. About 300 people (patients with both dementia and cancer, plus their caregivers) will take part. The goal is to see if the communication …

This study looks at how common meningitis is in northern Uganda, what causes it, and how to better diagnose and prevent it. Researchers will study 1,100 patients with meningitis symptoms and screen 10,000 HIV-positive people for a fungal infection that can lead to meningitis. The…

This study looks at how breast milk changes over time and throughout the day, and how these changes affect baby sleep and gut health. Researchers will compare 240 mothers who either breastfeed directly or pump milk. The goal is to help families make informed choices about feeding…

This study tests whether text message reminders can encourage people at high risk for lung cancer to get screened. About 40 participants aged 50 to 80 who smoke or recently quit will receive texts and be followed for 3 months. The goal is to see if this simple approach is practic…

This study looks at how the brain changes after a stroke that causes partial blindness. Researchers will use MRI scans to see which brain areas are damaged and how visual training might help the remaining healthy parts of the brain work better. The goal is to learn more about vis…

This study aims to understand why some breast cancer patients experience memory and concentration problems after chemotherapy. It will enroll 150 women with breast cancer starting chemotherapy and healthy women of similar age. Participants complete cognitive tests, blood draws, a…

This study follows 500 children and adults with Batten disease to learn how the condition changes over time. Researchers will measure movement, thinking, behavior, and daily skills. No treatment is tested—the goal is to better understand the disease and improve a rating scale use…

This study looks at why myotonic dystrophy type 1 affects people so differently—some have mild symptoms, others severe. Researchers will measure muscle strength, memory, and activity using tools mailed to your home, plus analyze your DNA from a blood sample. The goal is to find b…

This study looks at how the brains of people with Rett syndrome respond to sound. About 60 participants will wear a noninvasive EEG cap while listening to simple sounds. Parents or caregivers will also answer questions about symptoms and daily life. The goal is to better understa…

This study aims to develop tests that find tiny amounts of cancer cells left in the body after treatment for acute myeloid leukemia (AML) or high-grade myelodysplastic syndrome (MDS). By analyzing bone marrow samples, researchers hope to identify patients at higher risk of their …

This study creates a registry for people with myotonic dystrophy (DM) or facioscapulohumeral muscular dystrophy (FSHD) and their family members. The goal is to connect them with researchers to help study these inherited muscle-weakening diseases. Up to 3,000 participants will sha…