University Of Nottingham

This trial investigates whether using a device that sends mild electrical pulses to the thigh muscles (neuromuscular electrical stimulation, or NMES) can prevent muscle loss and weakness after abdominal surgery for colorectal or gastric cancer. Some participants will also receive…

This study tests a safe, low-dose electrical brain stimulation technique called tDCS to see if it can reduce the loudness and distress of tinnitus (ringing in the ears). Forty adults with tinnitus will receive multiple sessions, and researchers will measure changes in symptoms an…

This study looks at whether different types of exercise can reduce pain and improve daily function in people with chronic lower back pain. About 88 adults aged 18 to 45 will be placed into one of three groups: usual exercise, running, or swimming/cycling. Researchers will measure…

This study asks 30 staff and students at the University of Nottingham to review draft recruitment materials for a future study on thoracic aortic disease. Participants will give feedback on how clear, easy to read, and appropriate the documents are. The goal is to improve these m…

XLH is a rare genetic condition that causes low phosphate levels, leading to weak bones and pain. Burosumab is a standard treatment, but the best starting dose is still unclear. This study will review the medical records of 120 children across England to see if a lower dose (unde…

This study looks at when older men should take leucine supplements to best build muscle after exercise. Ten healthy men aged 65-75 will take leucine either with a meal or between meals after exercising. Researchers will measure how much new muscle protein is made to find the opti…

This study investigates how the brain chemical glutamate relates to memory and attention in people who have recently experienced psychosis. Researchers will use brain scans and a mild electrical stimulation technique called tDCS to see if glutamate levels can predict who responds…

This study looks at better ways to check kidney function after acute kidney injury (AKI). Researchers will compare two blood tests (creatinine and cystatin C) to see which is more reliable. They will also interview patients about their recovery experiences and hold workshops to d…

This study looks at how sleep problems—like trouble falling asleep or waking up often—affect people who have had a traumatic brain injury (TBI). Researchers will track sleep with a movement monitor and ask participants about their daily life and mental health. The goal is to unde…

This study looks at how linaclotide, a drug for constipation, affects fluid in the gut. Researchers will use MRI scans to see where the drug works in the small and large intestines. The goal is to learn more about its effects, which could help design future studies for conditions…

This study looks at how a new type of whey protein, called 'super-whey,' affects muscle building in older adults. Researchers will test three different doses to see which one works best, both at rest and after exercise. The goal is to find a low-dose protein option that helps mai…

This study observes 50 adults with drug-induced liver injury to track how common and how long itching lasts. Researchers will compare them to patients with other liver conditions. The goal is to gather data needed for a future clinical trial to treat this distressing symptom.

This study looks at whether a whey protein with extra leucine (a key amino acid) helps older adults build muscle better than regular whey protein. Thirty healthy men over 65 will take the protein and have muscle biopsies to measure protein synthesis at rest and after exercise. Th…

This study is collecting tissue and fluid samples from 160 people with suspected liver, bile duct, or pancreatic cancers. Researchers want to understand these cancers better and test new imaging and sampling tools for earlier, more accurate diagnosis. The study does not test a ne…

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This study looks at whether adjusting the difficulty of online listening exercises can help adults with hearing problems learn better. Researchers will have 120 participants do 30 minutes of training per day for two weeks. The goal is to understand how task difficulty affects lis…

This study observes 160 cancer patients to understand why some develop liver injury from checkpoint inhibitor drugs. Researchers will track blood markers and genetic factors to identify who is at risk. No new treatment is tested; the goal is to improve diagnosis and monitoring.

This study talks to adults from Asian, Black African, Black Caribbean, or Mixed backgrounds about their experiences with healthcare at home or in community centres. The goal is to learn what makes it easier or harder for them to use these services. In a second phase, the study fo…

This study looks at how chronic knee pain and fibromyalgia change the way nerves talk to muscles. Researchers will test pain sensitivity, muscle activity, and physical function in 135 adults. No treatment is given—the goal is to better understand the role of the central nervous s…

This study tests a new device called ZenBud that uses ultrasound waves to stimulate the vagus nerve, a key nerve that controls relaxation and body functions. Researchers want to see if this method can safely change heart rate, brain activity, and mood in 30 healthy adults. The go…

This study looks at how increasing or decreasing physical activity changes the way your body works. Forty overweight adults aged 50-65 will either become less active for 3 months then retrain, or become more active for 6 months. Researchers will measure fitness, muscle strength, …

This study tests whether using a blood pressure cuff to create short periods of reduced blood flow in the arm can improve how the brain regulates its own blood supply. 45 healthy adults aged 65-85 will either do the therapy daily, three times a week, or a sham version for 6 weeks…