Rush University Medical Center

This study tests a pharmacist-led program to help adults with uncontrolled high blood pressure in underserved Chicago neighborhoods. Over 3 months, a mobile team provides blood pressure checks, medication management, and health education. The goal is to see if this community-base…

This study looks at whether giving multiple doses of tranexamic acid (TXA) by mouth or through a vein can reduce blood loss and the need for blood transfusions after spine surgery. It involves 604 adults scheduled for open back surgery who are at high risk for needing a transfusi…

This study looks at whether encouraging people to take part in enjoyable recreational activities can help them make healthier choices and lower their risk for heart disease, diabetes, and stroke. About 120 adults will have their health tracked, and some will get extra support to …

This study tests a 12-month church-based program to help African Americans with uncontrolled high blood pressure lower their numbers. About 312 adults aged 18 and older will join, focusing on healthy eating, medication adherence, and lifestyle changes. The goal is to see if this …

This study looks at whether using noninvasive breathing support (like a mask or nasal prongs) right after removing the breathing tube can help severely obese patients avoid needing the tube again. About 250 adults with a BMI of 40 or higher who have been on a ventilator for at le…

This study tests whether a team of doctors, nurses, and social workers can help African American and Latinx adults with uncontrolled high blood pressure lower their numbers. Participants will receive extra support beyond standard care. The goal is to see if this approach leads to…

This study compares two types of hip implants used in revision hip replacement surgery: a dual mobility cup and a standard single bearing cup with a large head. The goal is to see if the dual mobility design lowers the chance of the hip dislocating in the first year after surgery…

This study tests whether treating PTSD symptoms early can prevent short-term pain from turning into long-term chronic pain. Researchers will use either a nerve block (stellate ganglion block) or a talking therapy (cognitive processing therapy) in 345 adults with acute pain and PT…

This study tests whether a short course of oral steroids (methylprednisolone) taken after knee replacement surgery can reduce pain, the need for opioid painkillers, and nausea. About 420 adults having their first knee replacement will be randomly assigned to receive either the st…

This study tests whether a nerve block injection (called an erector spinae plane block) can quickly reduce low back pain in adults visiting the emergency department. About 62 participants will receive either the nerve block or a placebo shot, and their pain levels will be tracked…

This study compares two types of knee implants (constrained condylar vs. posterior stabilized) used in revision knee replacement surgery. The goal is to see which one leads to better patient satisfaction and surgical outcomes. About 170 adults who need a second knee replacement w…

This study compares two procedures for breaking up large or stuck bile duct and pancreatic duct stones: a low-power laser and a shock-wave device. About 40 adults will be randomly assigned to one of the two treatments during an ERCP procedure. The goal is to see which method clea…

This study looks at whether using blood flow restriction during exercise can help people regain leg strength and function more quickly after hip arthroscopy. About 56 adults aged 18 to 40 with hip tears or impingement will be randomly assigned to either the special training or a …

This study tests whether a new knee brace called KRONOS helps people recover better than the standard Breg T-Scope brace after ACL reconstruction surgery. About 40 adults who are having ACL surgery will be randomly assigned to one of the two braces. The main goal is to see which …

This study compares two knee braces for people with knee arthritis affecting the inner part of the knee. Researchers will measure changes in pain and walking ability over 8 weeks. Participants must be 40-85 years old, have moderate pain, and be willing to wear the brace at least …

This study tests whether a computer-based training program can help people with Huntington's disease better understand others' emotions and social cues. Twenty participants will use the program at home and come in for follow-up visits. The goal is to see if this approach is pract…

This study tests a single infusion of a new drug called (2R,6R)-HNK to see if it can reduce nerve pain in the arms or legs. 25 adults with chronic nerve pain will receive the new drug, ketamine, or a placebo in random order, with 5 weeks between each treatment. Researchers will m…

This study tests a program called NurseNET, where nurses are trained to provide a short-term PTSD therapy called Narrative Exposure Therapy. The goal is to make PTSD treatment more accessible for people who see their primary care doctor. Researchers will enroll 100 adults with PT…

This study tests two different vibrating devices that help people with lung problems cough up mucus. Researchers want to see which device works better at clearing airways. The study will include 64 adults who have trouble clearing lung secretions. Results could help doctors choos…

This study tests whether morning bright light therapy can help people with Crohn's disease or ulcerative colitis by reducing gut leaks and inflammation. About 30 adults with stable medication will use a light box each morning for 8 weeks. Researchers will check changes in gut bar…

This study tests whether adding a nerve block injection (stellate ganglion block) to standard talk therapy (cognitive processing therapy) helps reduce PTSD symptoms more than either treatment alone. About 270 adults with PTSD will be assigned to one of three groups: combination t…

This study tests a virtual, parent-led therapy program for children aged 2-12 with genetic syndromes like Fragile X, Angelman, or Rett syndrome. The therapy focuses on teaching better communication and behavior strategies through weekly online coaching sessions. Researchers will …

This study tests whether prebiotics (dietary fibers) can improve gut health and reduce inflammation in people living with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for several weeks, then switch to the other. Researchers …

This study looks at how and why COPD self-management programs help people stay out of the hospital and feel better. Researchers will test different parts of the program in 448 adults with COPD who have been hospitalized in the past year. The goal is to find the most effective pie…

This study looks at whether giving ICU doctors a special risk score (called ProVent-14) helps them better predict if a patient on a breathing machine for two weeks will survive one year. About 238 doctors, nurses, and other ICU staff will take part. The goal is to see if the scor…

This study looks at what happens when the first PTSD therapy doesn't work. Researchers will offer a second round of proven treatments to 400 adults and track which ones help most. The goal is to create a simple tool to identify early who might need a different approach, so care c…

This study looks at whether pulse oximeters—the clips placed on fingers to measure oxygen levels—are less accurate for people with darker skin. Researchers will compare readings from two different oximeters with oxygen levels measured directly from blood in about 194 adults alrea…

This study tests whether a special nerve monitoring device (NeuroVision) can better prevent nerve damage during spine surgery compared to standard hospital monitoring. About 148 adults having lateral spine surgery will be randomly assigned to one of the two monitoring methods. Th…

This study looks at why people with lower income often have a harder time losing weight in behavioral programs. Researchers will track daily experiences and decision-making patterns in 230 adults with obesity. The goal is to find out what barriers exist so future treatments can b…

This study looks at whether showing people a real-time ultrasound of their heart in the emergency room can motivate them to eat better, exercise more, and see their doctor. About 100 adults aged 45+ with high blood pressure, diabetes, or obesity will either get standard education…

This study looks at whether the time of day a breathing test is done affects how quickly ICU patients can come off a ventilator. About 348 adults who have been on a ventilator for more than two days will be split into two groups: one gets the test early in the morning, the other …