Laser vs. shock wave: which breaks tough stones better?

NCT ID NCT07418112

Recruiting now Symptom relief Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two devices used during an ERCP procedure to break up large or stuck stones in the bile or pancreatic ducts. Forty adults will be randomly assigned to receive either low-power holmium laser lithotripsy or electrohydraulic lithotripsy. The main goal is to see which method clears the stones more completely in one session, and to check for side effects over 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: holmium laser lithotripsy device
What this could lead to: If successful, this could show that a low-power laser is a safer or more effective way to break up large bile or pancreatic duct stones compared to the standard shock-wave method.
What could go wrong: This is a small, early-phase trial with only 40 participants, so results may not apply to everyone. Both procedures carry risks like bleeding or infection, and the laser may not work better than the current approach.

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Conditions

The condition(s) this trial relates to.

choledocholithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOLEDOCHOLITHIASIS PANCREATIC DUCT STONE

Contacts and locations

Locations

Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States

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