Oslo University Hospital

This study compares two weight-loss surgeries—SASI bypass and sleeve gastrectomy—in 220 adults with severe obesity. The goal is to see which one leads to more weight loss and fewer problems like acid reflux. Participants will be randomly assigned to one of the two procedures and …

This study compares proton therapy to standard photon radiation for people with slow-growing brain tumors (IDH-mutated gliomas). The goal is to see if proton therapy, which targets tumors more precisely, can reduce side effects and maintain quality of life without shortening surv…

This study compares two treatments for chronic low back pain lasting over a year: lumbar fusion surgery and a structured rehab program. About 202 adults aged 20-65 will be randomly assigned to one of the two. The goal is to see if surgery reduces disability more than rehab over t…

This study tests two treatments for a type of bile duct cancer that cannot be surgically removed. One delivers chemotherapy directly to the liver through a pump, and the other uses tiny radioactive beads injected into the tumor's blood supply. Both are given alongside standard ch…

This study tests whether a higher dose of proton radiation can better control inoperable soft tissue sarcomas without increasing side effects. Forty adults with these rare tumors will receive targeted radiation over 4 weeks. Researchers will also look at blood and imaging markers…

This study tests whether a personalized 3-week course of proton radiation before surgery for soft tissue sarcoma can reduce long-term side effects compared to standard X-ray radiation. About 110 adults in Norway will receive either proton or X-ray therapy, chosen individually for…

This pilot study is testing a Norwegian e-health program called DiaMester for adults with type 2 diabetes. The program includes digital education, coaching, and a low-calorie diet to help participants lose weight and potentially achieve diabetes remission. About 99 people will ta…

This early-phase trial tests a cancer vaccine (Pseudovax) combined with an immune booster and an immunotherapy drug in 10 people with pseudomyxoma peritonei, a rare abdominal cancer that has come back or cannot be removed. The goal is to see if the treatment is safe and can react…

This study compares CT and MRI scans to see which more accurately determines if bladder cancer has spread into the muscle layer. About 150 adults with newly diagnosed bladder cancer will receive both scans before standard surgery. The results will be checked against tissue sample…

This study tests whether a remote expert can guide a bedside ultrasound to detect free fluid (like blood or ascites) in patients who just had liver surgery. Forty participants will receive a telementored eFAST exam, and its accuracy will be compared to standard CT scans and exper…

This study tests whether a personalized exercise program can improve balance and physical function in adults with rare neuromuscular disorders like Charcot-Marie-Tooth disease, facioscapulohumeral muscular dystrophy, and myotonic dystrophy type 1. Participants will receive a 12-d…

This study tests if proton radiation causes fewer side effects than standard photon radiation in people with head and neck cancer. About 400 adults aged 40 and older will receive either proton or photon therapy, plus possible chemotherapy. The main goal is to see if protons reduc…

This study tests a two-week intensive outpatient treatment for people with PTSD, combining prolonged exposure and EMDR therapy. Up to 42 participants will receive daily therapy sessions and be followed for 12 weeks. Researchers will measure changes in PTSD symptoms, quality of li…

This study tests whether combining spinal cord stimulation with a rehabilitation program can reduce chronic nerve pain in the legs and improve physical function. Ten adults aged 18-60 with nerve pain lasting over 6 months will receive the treatment bundle. The goal is to see if t…

This study tests whether a new 5-day outpatient therapy called Temperament Based Therapy with Support (TBT-S) can help reduce eating disorder symptoms in adults with anorexia nervosa. 120 participants will either receive TBT-S plus their usual care or usual care alone. Researcher…

This study compares standard radiation therapy to a newer method called dose painting for people with head and neck cancer. The goal is to see if dose painting causes fewer severe mouth ulcers one year after treatment. About 100 participants will be randomly assigned to receive e…

This study compares two types of talk therapy for teenagers with eating disorders: enhanced cognitive-behavior therapy and family-based treatment. About 200 adolescents will be randomly assigned to one of the two therapies. The goal is to see if cognitive-behavior therapy works a…

This pilot study tests a new type of talking therapy designed for people with early psychosis who experience 'self-disorders' — a feeling of being disconnected from themselves. Eight adults with schizophrenia or psychosis risk will receive the therapy and then be interviewed abou…

This study follows 500 adults with lupus to see if blood and urine tests can reliably detect kidney inflammation (lupus nephritis). Participants give samples during routine visits, and doctors track their kidney health over time. The goal is to find simple, non-invasive markers t…

This study is testing whether an advanced MRI technique called Quantitative Susceptibility Mapping (QSM) can better tell apart brain lesions caused by multiple sclerosis (MS) from those due to normal aging or small vessel disease. Researchers will scan 1,000 people aged 50-70 wit…

This study looks at how people with celiac disease react to gluten in liquid form (a shake) versus solid form (a cookie). Thirty adults on a gluten-free diet will try both, in random order, with blood samples taken to measure immune markers and symptoms. The goal is to see if liq…

This study is observing about 1,950 emergency patients with suspected sepsis to see if new blood tests (like calprotectin and bacterial DNA tests) can detect infections faster and more accurately than current methods. The goal is to find better ways to diagnose sepsis and tailor …

This study observes 340 patients in Norway who need gallbladder surgery and also have bile duct stones. Doctors will use one of two methods to remove the stones during surgery: a laparoscopic technique through the bile duct or an endoscopic procedure. The goal is to see which met…

This study is following 300 people in Norway who have had a spontaneous coronary artery dissection (SCAD), a rare cause of heart attacks, especially in women. Researchers will use scans, blood tests, and questionnaires to track their health for one year. The goal is to better und…

This study tests a new tool to help surgeons balance knee ligaments during total knee replacement. The goal is to see if the tool makes the procedure more accurate and repeatable. About 40 adults with knee arthritis will take part. The study focuses on measuring how much the liga…

This study tracks bone growth in 10 children who have surgery to fix leg length differences or bowing. Surgeons place small metal markers in the bone and use special X-rays to measure growth very precisely. The goal is to learn when to remove temporary implants for the best resul…