Oslo University Hospital

This study tested whether blood thinners (DOACs) work better than aspirin to prevent valve damage and serious heart problems after a less invasive aortic valve replacement (TAVI). 360 patients aged 65-80 were randomly assigned to take either a DOAC or aspirin daily. The main goal…

This Phase 3 trial tested whether the clot-busting drug tenecteplase could improve vision in people with a central retinal artery occlusion (eye stroke). 81 participants received either tenecteplase or aspirin within 4.5 hours of symptoms. The main goal was to see if more patient…

This study tested whether a procedure called extracorporeal photophoresis (ECP) could prevent graft-versus-host disease (GVHD) in 158 people receiving stem cell transplants for blood cancers. ECP involves removing white blood cells, treating them with a light-sensitive drug and U…

This study looked at how well patients aged 75 and older tolerate chemotherapy after surgery for stage III colon cancer. Researchers measured changes in daily living activities and used geriatric assessments and gene tests to predict outcomes. The goal is to better identify which…

This study compares two ways to check if a baby is getting enough oxygen during labor: measuring lactate from a tiny scalp blood sample and analyzing the fetal heart's electrical signal (STAN). Researchers will look at which method better identifies babies at risk of low oxygen, …

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study tested whether a standard allergy work-up can accurately identify people who were incorrectly labeled as allergic to penicillin. 155 adults with a suspected penicillin allergy went through testing, including a drug challenge to confirm if they were truly allergic. The …

This study looked at 80 adults having wrist fracture surgery to see if a lower concentration of the local anesthetic ropivacaine (3.75 mg/ml vs. 7.5 mg/ml) in a nerve block affects the severity of pain when the block wears off. Participants were randomly assigned to one of the tw…

This study looked at whether cutting out certain carbs (FODMAPs) can help people with celiac disease who still have stomach issues even after following a gluten-free diet. Researchers surveyed and then ran a controlled trial with 80 adults who had celiac disease and irritable bow…

This study looked at whether a single intravenous iron dose could improve exercise capacity in people with severe aortic stenosis and iron deficiency who were scheduled for a valve replacement. About 100 participants received either iron or a placebo. The main goal was to see if …

This study looked at whether cancer patients already taking strong opioids like morphine can stop taking paracetamol without their pain getting worse. 204 adults with metastatic cancer and stable pain on both medications were randomly assigned to continue paracetamol or switch to…

This completed study in Norway looked at how opioids like morphine, oxycodone, and fentanyl affect patients' mood and pain right before surgery. Over 1,000 healthy adults scheduled for day surgery answered questions about anxiety, relaxation, and pain after receiving a small dose…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This completed study in 15 healthy volunteers tested how a small amount of Ringer's acetate (a common IV fluid) affects heart function and brain blood flow when blood volume is low. Participants were given the fluid during both normal and low blood volume conditions (simulated us…

This completed study from Oslo University Hospital looked for bacteria in the discs and bones of 200 people with chronic low back pain who were having spine surgery. Researchers took tissue samples during surgery and used lab tests and genetic sequencing to detect any bacteria. T…

This completed study from Oslo University Hospital involved 33 adults with celiac disease who followed a strict gluten-free diet. Over five separate one-day challenges, participants consumed wheat gluten, barley gluten, hydrolyzed barley gluten, or a placebo. Researchers measured…

This study tested a quick, one-minute risk matrix to predict which patients will have severe pain after gynecologic laparoscopy done as day surgery. Researchers followed 487 women and checked if the tool could identify those at high risk. If it works, doctors could use it to plan…

This study looked at whether using EEG brain-wave monitoring during general anesthesia helps doctors give the right amount of medicine. The goal was to help patients wake up faster after surgery and reduce memory or thinking problems. About 100 adults having surgery took part. Re…

This study looked at whether the amount of propofol (anesthesia medicine) in a child's breath matches the amount in their blood during eye surgery. 32 children took part, and the researchers compared breath measurements with blood samples and brain activity. The goal was to see i…

This completed study compared the heart effects of two drugs, oxytocin and carbetocin, given to prevent bleeding after childbirth. Researchers measured a heart injury marker (troponin I) in 240 healthy pregnant women after delivery. The goal was to see if carbetocin might be less…

This study looked at how much a new knee implant (GMK Sphere) moves inside the body over five years in 44 people with knee osteoarthritis. Researchers used a special X-ray technique to measure implant stability. The goal was to gather data to help design better knee replacements …

This study looked at how well a new type of uncemented knee implant stays in place over time in people with knee osteoarthritis. Researchers measured implant movement and bone quality in 31 patients who had knee replacement surgery. The goal was to check if the implant is safe an…

This study looked at how often people have vision problems after a stroke. Researchers followed 127 stroke patients for 3 months, testing their eyesight and comparing results with brain scans. The goal was to find out how common these issues are and whether a simple vision screen…