New study tests if proton radiation can spare brain tissue without hurting survival

NCT ID NCT05190172

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares proton therapy to standard photon radiation for people with slow-growing brain tumors (IDH-mutated gliomas). The goal is to see if proton therapy, which targets tumors more precisely, can reduce side effects and maintain quality of life without shortening survival. About 225 adults aged 18-65 will take part, and researchers will track survival, fatigue, and thinking skills for two years after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Radiation therapy (proton or photon)

What this could lead to

If proton therapy works as well as standard photon therapy, it could reduce side effects and improve quality of life for people with certain brain tumors.

What could go wrong

This is a mid-stage trial with 225 participants, so results are not final. Proton therapy might not be as effective at controlling the tumor, and long-term survival data are still being collected.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

anaplastic oligodendroglioma astrocytoma (excluding glioblastoma) astrocytoma, IDH-mutant, grade 2 astrocytoma, IDH-mutant, grade 3 diffuse astrocytoma oligodendroglioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Oslo University Hospital

    RECRUITING

    Oslo, Norway

    Contact Phone: •••-•••-•••• Email: •••••@•••••