Nyu Langone Health

This study tests a precise radiation technique called VMAT for people with solid tumors that have spread to the lining of the brain and spine (leptomeningeal metastasis). The goal is to see if this approach can delay cancer progression in the central nervous system better than st…

This study tests whether a structured diet, exercise, and lifestyle program can help prevent uterine fibroids from coming back after surgical removal. Researchers will enroll 100 women aged 18-50 who are currently fibroid-free after surgery. Participants will follow the LIFE prog…

This study tests whether a lower dose of certain drugs can prevent graft-versus-host disease (GVHD) in adults receiving a stem cell transplant from a half-matched donor. GVHD is a serious condition where donor cells attack the patient's body. The trial uses a combination of three…

This study looks at whether offering alcohol use disorder treatment in Black churches helps more people start and stay in treatment compared to traditional specialty clinics. About 137 Black adults with alcohol problems will be randomly assigned to either a church-based program o…

This study tests a program to help Black patients with uncontrolled high blood pressure. It combines nurse support, home blood pressure monitoring, and help with social needs like housing or food. About 500 adults from 25 clinics in New York City will take part. The goal is to se…

This study tests if a shorter course of radiation (3 doses over 5 days) is as safe and effective as the standard 5 doses over 5 days for women with early-stage breast cancer. The trial involves 284 post-menopausal women who have had their tumor removed. The main goal is to see if…

This early-phase study tests a combination of two standard chemotherapy drugs plus two immune-boosting drugs in people with pancreatic cancer that can be surgically removed. The main goal is to see if the combination is safe and tolerable, and whether it helps more patients succe…

This study tests a three-drug combination for people with advanced melanoma that cannot be removed by surgery. The goal is to see if adding tocilizumab to standard immunotherapy (ipilimumab and nivolumab) can reduce severe immune-related side effects while still controlling the c…

This study uses advanced PET and MRI brain scans to look for inflammation and blood vessel problems in people with long COVID who have brain fog, anxiety, or depression. Researchers will scan 30 participants and compare their results to healthy volunteers. The goal is to develop …

This study aims to make MRI scans clearer for people with heart arrhythmia (irregular heartbeat). Researchers will test two special imaging methods on 135 participants, including 105 patients with arrhythmia and 30 healthy volunteers. The goal is to reduce blurry images caused by…

This study tests a new, faster breast MRI technique called GRASP. The goal is to see if it can accurately tell the difference between harmless and cancerous breast lumps. About 264 women who already need a breast MRI will take part. If successful, this could lead to quicker and m…

This small pilot study tests whether a dissolvable film containing dexmedetomidine can be used at home to treat sudden, severe episodes (autonomic crises) in people with familial dysautonomia, a rare nerve disorder. Five adults who have had these crises before will receive the fi…

This study tests whether taking creatine supplements can improve voice quality in people over 65 who have age-related voice changes (presbyphonia). Twenty participants will be randomly assigned to receive either creatine or a placebo for 10 weeks. Researchers will measure voice f…

This pilot study is testing whether virtual reality treadmill training can help people with traumatic brain injury improve their balance, mobility, and confidence. Twenty adults aged 18 to 90 who have had a TBI at least one year ago and have balance issues or a history of falls w…

This study tests whether a nerve block injection in the neck can help reduce symptoms of post-traumatic stress disorder (PTSD). About 79 adults with chronic PTSD will receive either the nerve block or a placebo (salt water) injection. Researchers will measure changes in brain act…

This study looks at whether wearing a splint and doing formal physical therapy are necessary after surgery for a broken wrist. 230 adults with a specific type of wrist fracture will be followed to see if early movement (no splint, self-guided exercises) leads to better outcomes a…

This study tests a phone-delivered mindfulness program for people scheduled for spine surgery who worry a lot about pain. About 25 adults will take part in weekly sessions before surgery and be followed for two weeks after. The goal is to see if the program is helpful and satisfy…

This study tests whether giving magnesium sulfate during prostate surgery can lower pain and the need for strong painkillers. About 68 adults having robotic prostate surgery will either receive magnesium or not. Researchers will measure pain scores, opioid use, and recovery after…

This study tests a light therapy device that shines near-infrared light on the forehead to see if it can improve memory and thinking in people with early Alzheimer's disease or mild cognitive impairment. About 196 older adults (ages 65-85) will receive either real or fake light t…

This study tests a medicated film placed under the tongue to quickly ease severe episodes (autonomic crises) in people with familial dysautonomia, a rare nerve disorder. About 15 participants aged 16 and older will receive either the drug or a placebo during a crisis. The goal is…

This study looks at whether exercise can ease anxiety in adults who are not very active. 111 people with anxiety disorders will do either low-intensity or high-intensity exercise for 8 weeks. Researchers will track changes in anxiety symptoms and how exercise affects mood and mot…

This study tests whether applying cold (cryotherapy) to hands and feet can prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with stage III colon cancer. About 40 participants will be randomly assigned to receive cryotherapy or not during their standard c…

This study tests whether advanced MRI scans can predict the type of kidney cancer and how well the kidney will work after surgery. About 39 adults scheduled for partial kidney removal will have special MRI scans before their operation. The goal is to see if these scans can help d…

This study looks at two methods to help pregnant women adopt healthy habits: one uses text messages and online videos, the other uses community health workers for group or individual counseling. Researchers will enroll 1,050 pregnant women to see which approach works better and i…

This study tests a new device called Napoleon that helps doctors measure the size of the connection between the stomach and small intestine in people who had gastric bypass surgery and later regained weight. About 100 patients will have the connection measured both by the doctor'…

This study looks at how stimulating a nerve in the ear during cochlear implant surgery changes pupil size. Researchers will measure pupil dilation in 30 adults to learn more about how the vagus nerve works. The goal is to gather knowledge, not to treat hearing loss directly.

This study follows over 5,000 people with stable heart disease who were previously treated with either an invasive approach (like stents or bypass surgery) plus medications, or medications alone. Researchers want to see which strategy leads to fewer deaths from heart problems or …

This pilot study tests a community-based educational program to improve melanoma knowledge and skin self-exams in Brooklyn adults. 45 participants enrolled.

This study looks at how normal age-related sleep changes and sleep apnea might increase the risk of Alzheimer's disease in healthy older adults. Researchers will monitor sleep and brain amyloid levels in 158 people aged 55-75 over two years. The goal is to find ways to prevent Al…

This study looks at whether offering hearing screening and counseling during a regular doctor's visit can help underserved older adults with hearing loss. Participants will either get advice on affordable listening devices or be sent to a hearing specialist. The goal is to see if…

This study looks at whether offering parenting support to all families with very young children in Flint, Michigan can help kids' development and mental health after the Flint water crisis. About 486 families with infants up to 3 months old are taking part. Researchers measure pa…

This study tests new MRI software to see how the heart and lungs interact during breathing. About 100 adults with heart disease will get extra scans. The goal is to improve image quality and make scans faster and easier for routine use.

This study tests a simple reminder system for doctors to order liver ultrasounds for people with cirrhosis, who are at higher risk for liver cancer. About 1300 adults with cirrhosis who haven't had recent imaging will be included. The goal is to see if the reminder increases the …

This study looks at whether giving a blood transfusion to adults whose heart has stopped beating for at least 10 minutes can improve oxygen delivery to the brain and other organs during CPR. About 30 participants will be randomly assigned to receive either packed red blood cells …

This study looks at why some people have a heart attack even when their main heart arteries are not blocked. Researchers use special cameras to see inside the arteries and the heart muscle in 15 participants. The goal is to learn more about what causes these unusual heart attacks…