Meyer Children's Hospital Irccs

This study tests whether adding a special skin glue around the IV site can prevent the IV from slipping out in children visiting the emergency room. About 300 kids aged 0-18 who need an IV for at least 24 hours will take part. The goal is to reduce complications like leaks, block…

This study tests whether L-serine, a dietary supplement, can improve overall functioning in 40 children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by loss-of-function gene variants. Each participant will receive both L-serine and a placebo …

This study tests whether a special high-fat, low-carb diet (ketogenic diet) can help 30 children and young adults with brain tumors lose at least 5% of their body weight over 24 months. Participants have central obesity caused by their tumor or its treatment. The diet aims to imp…

This study gathers information from people with CACP syndrome, a rare genetic condition that causes joint stiffness, hip problems, and sometimes heart inflammation. Researchers aim to collect data from 15 participants across Europe to better understand how the disease progresses …

This study aims to learn more about eosinophilic fasciitis, a rare connective tissue disease, in children. Researchers will collect information from up to 20 children diagnosed before age 18 to describe symptoms, how the disease progresses, and how it responds to current treatmen…

This study looks at why children with short bowel syndrome respond differently to the drug teduglutide. Researchers will grow tiny, lab-made intestines (organoids) from tissue samples taken during routine surgery. They will then treat these mini-intestines with teduglutide in the…

This study looks at how well hospitals follow the latest GINA 2025 guidelines when treating children (ages 6-17) having asthma attacks. Researchers will check if using these guidelines leads to better diagnosis, treatment, and follow-up care. The goal is to improve care for kids …

This study is testing two scoring systems (Kobayashi and Kawanet) to see if they can predict which children with Kawasaki disease will not respond to standard IVIG treatment. The goal is to identify high-risk children early so they can receive stronger initial therapy and avoid h…

This study looks for specific immune system markers (autoantibodies) in the blood and kidney tissue of children with nephrotic syndrome, a condition causing swelling and protein loss. Researchers aim to understand how these markers relate to disease activity and treatment respons…

This study aims to better understand Behçet disease in children by analyzing blood samples for biomarkers like cytokines, microRNAs, and DNA changes. Researchers will compare children with Behçet disease to adults with the condition and healthy children. The goal is to identify p…

This study looks at whether measuring infliximab levels in saliva is as good as measuring it in blood for children with inflammatory bowel disease (IBD). Fifteen children starting infliximab will give saliva and leftover blood samples during routine visits. The goal is purely to …

This study looks at how children's ability to understand emotions, their attachment style, and thinking skills relate to physical symptoms like stomach pain or headaches with no clear medical cause. Researchers will assess 300 children to see if lower emotional awareness and inse…

This study looks at 500 children who had surgery for a rare birth defect affecting the anus and rectum. Researchers will compare different surgical techniques to see which one leads to better bowel control years later. The goal is to find the best approach to improve long-term qu…

This study looks at gut bacteria in children aged 3 to 18 who are suspected of having a brain tumor. Researchers will analyze stool samples to see if changes in bacteria can help detect the tumor or track its progress. No treatment is given—the goal is simply to learn more about …

This study looks at how certain psychiatric drugs affect the heart's electrical activity in children and teens. Researchers will track 100 young patients starting these medications, checking their ECGs at the start and after 3, 6, and 12 months. The goal is to find out how often …

This study looks at children under 18 in Italy who have leishmaniasis, a parasitic infection that can affect the skin or internal organs. Researchers want to learn how quickly the disease is diagnosed and treated, and how delays impact recovery and relapse. By collecting data fro…

This study reviews medical records of 60 newborns who had signs of possible intestinal blockage before birth. Researchers want to find out which ultrasound measurements best predict whether a baby will actually have a blockage after delivery. The goal is to help doctors give bett…

This study looks at people with rare changes in the COL4A1 or COL4A2 genes, which can cause bleeding in the brain and damage to other organs. Researchers will collect medical information and blood samples from 120 participants and their family members to find early signs of disea…

This study looks at how the cystic fibrosis drug combination ETI (elexacaftor-tezacaftor-ivacaftor) affects metabolism, gene activity, and gut bacteria in 150 people with CF. Researchers want to understand why some patients develop side effects like high cholesterol or obesity. T…

This study follows 290 children with a rare, long-term eye inflammation called non-infectious chronic uveitis. Researchers will track symptoms, lab results, and how well different treatments work over several years. The goal is to better understand the disease and find ways to pr…

This study looks at tumor and blood samples from 50 children aged 3-18 with brain tumors to find genetic changes and test how tumors respond to drugs in 3D lab models. The goal is to better understand why some tumors resist treatment and to pave the way for more personalized ther…

This study looks at whether using lung ultrasound to diagnose pneumonia in children aged 3 to 10 can cut down on unnecessary antibiotic use. Currently, doctors often rely on exams and chest X-rays, which aren't always accurate. The goal is to see if ultrasound can guide better tr…

This study tests a new, safe ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, like brittle bone disease or osteoporosis. Unlike standard X-ray methods, REMS uses no radiation. The goal is to see how well REM…

This study is for people with Erdheim-Chester disease (ECD), a rare condition that causes abnormal cells to build up in bones and organs. Researchers will collect medical data from 1,000 patients to find patterns that predict survival and disability. The goal is to create a tool …