China National Center For Cardiovascular Diseases

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This trial will compare three drugs—dopamine, norepinephrine, and epinephrine—to see which works best for people experiencing a pulmonary hypertensive crisis, a life-threatening spike in blood pressure in the lungs. The study will enroll 75 adults with pulmonary arterial hyperten…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…

This study tests whether using a computer simulation (virtual stenting) before placing stents in heart arteries can lead to better outcomes than the usual method guided by X-ray images alone. About 1,472 adults with coronary artery disease will be randomly assigned to either the …

This study tests a new way to treat atrial fibrillation (AFib), a condition where the heart beats irregularly. Doctors will use pulsed field ablation (PFA) instead of heat or cold to create scars in the heart and block bad signals. They will also use a special 3D ultrasound syste…

This study tests whether the drug finerenone can reduce scarring in the heart muscle and improve heart structure and function in people with heart failure. About 104 adults with mild to moderate heart failure will receive either finerenone or a placebo for 6 months. The main goal…

This study tests whether using only ultrasound (echocardiography) to guide a minimally invasive heart valve replacement is as effective as the standard method that combines X-ray and ultrasound. The goal is to reduce kidney injury from contrast dye and lower radiation exposure. A…

This study tests whether adding exercise-focused lifestyle coaching to a personalized diet plan improves health in 435 overweight or obese adults with metabolic syndrome. Participants will either follow a diet plan alone or a diet plan plus an intelligent lifestyle program that t…

This study compares two types of drug-coated balloons used to open blocked heart arteries in people with acute coronary syndrome (a serious heart condition). About 60 adults will receive either a sirolimus-coated or paclitaxel-coated balloon. The main goal is to see which balloon…

This study tests whether a daily low-dose anti-inflammatory drug (colchicine) can prevent blood clots from forming on replacement heart valves after a minimally invasive valve procedure (TAVR). About 116 people who have had TAVR will either receive colchicine plus standard care o…

This study tests whether the drug nicorandil can improve blood flow in the heart's tiny vessels after a heart attack. About 170 patients having emergency angioplasty will receive either nicorandil or a placebo directly into their heart artery. The goal is to see if nicorandil red…

This study tests whether an AI-powered app called 'Smart family doctor' can help people who have had heart surgery (bypass or stent) better control their blood pressure, blood sugar, and cholesterol. About 951 participants from 10-20 hospitals will use the app for personalized he…

This study tests a new way to close a common heart hole (atrial septal defect) using only ultrasound, without X-rays or cuts. The procedure is done inside a specially equipped mobile surgical unit, bringing care to remote areas. About 300 people aged 8 and older will take part to…

This study tests whether a robotic system can safely assist doctors in opening blocked heart arteries. About 170 adults with coronary artery disease will be randomly assigned to receive the standard procedure or one assisted by the robot. The goal is to see if the robot can reduc…

This trial tests a tool called SCOUT that helps doctors check AI-generated diagnoses for coronary heart disease. Seven cardiologists will review cases either with SCOUT's assistance or through standard manual review. The goal is to see if SCOUT can reduce the time doctors spend p…

This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP), given continuously during and after heart surgery, can prevent acute kidney injury. It includes 694 high-risk adults undergoing elective heart surgery with a heart-lung machine. Participan…

This study tests whether closing the left atrial appendage (a small pouch in the heart) during valve surgery can prevent silent brain injuries in 100 adults without atrial fibrillation. Participants will have brain scans after surgery to check for hidden strokes. The goal is to f…

This study looks at 421 people who are getting a heart device (ICD) to see if muscle health can help predict sudden cardiac death. Researchers will use AI to combine muscle scans, blood tests, and other data to build a risk prediction tool. No new treatments are tested—the goal i…

This study will develop a computer model that uses machine learning to predict a patient's risk of developing acute kidney disease after heart surgery. Researchers will collect data from 820 adults undergoing certain heart procedures to build and test the model. The goal is to cr…

This study develops and tests an AI system that reads de-identified patient admission notes to classify four types of coronary syndromes, including heart attacks and angina. The tool is designed to protect patient privacy while helping doctors diagnose more accurately and quickly…

This study compares two imaging methods—CT-FFR and QFR—to see which better guides treatment decisions for people with coronary artery disease. About 1,400 participants with moderate blockages will be randomly assigned to one of the two approaches. The goal is to find out which me…

This study tests whether AI-generated video feedback can help cardiac surgeons improve their technique in coronary artery bypass grafting. One hundred surgeons will submit a video of their surgery, receive AI-created clips highlighting areas for improvement, then submit a follow-…

This study looks at ways to help surgeons use more artery grafts instead of vein grafts during heart bypass surgery, since artery grafts last longer. It will involve about 8,700 patients across many hospitals. The study does not test a new drug or device, but rather tests trainin…

This study compares two ways of making treatment decisions for people with diabetes and severe blockages in all three main heart arteries. One group gets a real-time online discussion among heart specialists during an angiogram, while the other gets usual care. The goal is to see…

This study aims to create a risk model that helps doctors decide which elderly patients (over 70) with heart disease need procedures like stents or bypass surgery. Researchers will collect CT scans, blood tests, and frailty assessments from 800 participants and follow them for tw…

This study will follow 6,000 people in China who have both coronary heart disease and a leaky heart valve (ischemic mitral regurgitation). Researchers will collect medical data and track outcomes like hospitalizations and deaths over two years. The goal is to understand the disea…