Children's Hospital Of Philadelphia

This study tested whether sending text message reminders to parents could increase flu vaccination rates among children. Over 228,000 kids aged 6 months to 18 years from the Children's Hospital of Philadelphia network took part. Researchers compared vaccination rates 30 days afte…

This study looked at over 9,000 children with septic shock (a life-threatening infection) to see if a balanced salt solution is better than normal saline for preventing kidney damage. The goal was to find out which fluid reduces the risk of death, need for dialysis, or lasting ki…

This study looked at whether adding a community health worker to the care team helps children with type 1 diabetes. 84 children with type 1 diabetes took part. The goal was to see if this support improves blood sugar control, reduces hospital visits, and helps kids attend more do…

This study tested whether dupilumab, a drug that blocks type 2 inflammation, can help children and young adults (ages 6-25) with eosinophilic esophagitis safely add back foods like milk, egg, soy, or wheat into their diet. The 21 participants were monitored for changes in esophag…

This study looked at whether a home sleep apnea test can accurately check for sleep apnea in children who have already had their tonsils removed. Sixty-two children aged 5 to 12 took both a home test and an in-lab sleep study. The goal was to see if the simpler home test gives re…

This study tested a 10-week program called Protecting Families for depressed parents and their pre-teen children. The goal was to see if the program could help prevent depression in the kids. 42 families took part, and the study compared the program to parent training alone, look…

This study tested a new training program to help infants and toddlers with cerebral palsy move better. 42 children aged 12-36 months took part. The program aimed to improve gross motor skills and balance compared to standard care.

This early-phase study tested the safety and potential benefits of elamipretide for treating vision loss in people with Friedreich ataxia (FRDA). Twenty participants with advanced symptoms received either a low or high dose of the drug. The main goal was to see if it improved hig…

This study tested a behavioral sleep program called Sleep Well! for children ages 1 to 5 in urban primary care clinics. About 103 parent-child pairs took part. The goal was to see if the program was easy to use and helpful for families. Results showed families found it acceptable…

This study tested whether taking an NAD+ precursor (a vitamin-like supplement called NR) combined with exercise training can improve aerobic capacity (how well the body uses oxygen during activity) and blood sugar control in people with Friedreich's ataxia. 75 participants aged 1…

This study looked at whether teachers and school counselors can effectively run the Friend to Friend program to help girls who use relational aggression (like excluding others or spreading rumors). Over 5,000 students from 40 urban schools took part, with some schools using the p…

This study tested a remote training program to help school staff in rural areas deliver mental health support to students. Researchers worked with 174 school staff to see if the training was practical and effective. The goal was to improve access to care for children in underserv…

This study looked at whether a short video could help parents and teens better understand genetic testing after a child's cancer diagnosis. Researchers gave the video to 355 families at Children's Hospital of Philadelphia and measured their knowledge before and after receiving te…

This study measured levels of PEG 3350, a common laxative ingredient, in the blood and urine of children who take it regularly. Researchers compared these levels to children not taking the medicine and also checked for any behavior changes. The goal was to learn more about how th…

This study followed 89 children and young adults who had just finished treatment for acute lymphoblastic leukemia (ALL). Researchers wanted to see how often infections happen in the first year after treatment and whether patients still have protection from childhood vaccines. The…

This study looked at whether a digital care plan and text message reminders could help families of children with cancer predisposition syndromes (a higher genetic risk for cancer). Researchers worked with 164 families to see if the tool was easy to use and improved understanding …

This study tested whether automated electronic reports could help doctors prescribe antibiotics more appropriately for common infections like pneumonia, ear infections, and sore throat. Over 26,000 patients were included, and the reports compared prescribing patterns before and a…

This study looked at how to keep mental health supports running in under-resourced city schools. Over 400 students and staff from 12 schools took part to see which method worked better for delivering therapy programs. The goal was to improve student behavior, emotions, and classr…

This study enrolled 513 children on breathing machines due to acute respiratory distress syndrome (ARDS). Researchers collected blood samples to identify different biological types of the disease, aiming to better predict outcomes and tailor future therapies. No new treatment was…

This study tested a program called Care Coordination After Preterm Birth (CCAPB) to help mothers who had a preterm baby. The goal was to see if the program was acceptable and could reduce stress, improve health care use, and address issues like smoking and depression. 67 mothers …

This study looked at whether whole genome sequencing (a complete read of a person's DNA) can help doctors more accurately diagnose children with leukodystrophies—rare diseases that damage the brain's white matter. Researchers enrolled 236 children and their parents to see if this…

This study followed 60 babies at high risk for cerebral palsy from birth to 18 months old. Researchers used wearable sensors and robotic tools to measure how the infants learned to move—from early kicks to crawling and walking. The goal was to understand how motor skills develop …

This study tested a program to help doctors prescribe antibiotics more wisely for children with common respiratory infections like colds, ear infections, and sore throats. Over 1,000 clinicians participated across various outpatient settings. The goal was to reduce the use of bro…

This study tested a new digital tool that helps doctors make better decisions about teen sexual health, like STI testing. About 190 teens, parents, and doctors took part. The goal was to see if the tool was easy to use and helpful in real clinic visits.

This study tested a resource package designed to help caregivers use behavioral interventions for children with hyperactive, inattentive, or impulsive behaviors. Twenty caregivers of children in grades K-5 in the Philadelphia area used the package, and researchers collected feedb…

This study adapted a program called STAT-ED to better support Black youth who come to the emergency room with suicidal thoughts or behaviors. Researchers tested whether a patient navigator could help these young people and their families start and continue mental health treatment…