Children's Hospital Of Philadelphia

This trial investigates how the Fontan surgery, which reroutes blood flow in children born with a single heart ventricle, affects the liver and heart. Researchers use MRI scans and blood tests to measure fibrosis (scarring) and lymphatic congestion. They also test whether spirono…

This study tested whether teachers and counselors can effectively run the Friend to Friend (F2F) program to reduce aggression in girls. Over 5,000 students from 40 urban schools participated, with some schools using the program and others serving as controls. The program includes…

This large study tested whether a 'balanced' fluid (Lactated Ringer) is better than normal saline for children with septic shock. Over 9,000 kids participated across multiple hospitals. The goal was to see which fluid reduces the risk of serious kidney problems or death within 30…

This study tested whether adding a community health worker to the diabetes care team helps children with type 1 diabetes. The health worker provided home visits, social support, and help with setting health goals. The study included 84 children and looked at blood sugar control, …

This study tested whether the drug dupilumab can help children and young adults (ages 6 to 25) with eosinophilic esophagitis (EoE) safely reintroduce foods that normally trigger their symptoms. EoE is a condition where certain foods cause inflammation in the esophagus, and curren…

This study looked at whether a home sleep apnea test can accurately detect obstructive sleep apnea in children aged 5-12 who have already had their tonsils and adenoids removed. 62 children completed both a home test and an overnight in-lab sleep study. The goal was to see how we…

This study tested a 10-week program called the Protecting Families Program (PFP) for depressed parents and their pre-teen children. The goal was to see if the program could prevent depression in the children. 42 families took part, with parents in treatment for depression. The pr…

This study tested whether sending a one-time text reminder to parents could increase flu vaccination rates among children. Over 228,000 patients aged 6 months to 18 years at Children's Hospital of Philadelphia were included. Researchers compared vaccination rates 30 days after th…

This study tested a resilience coaching program (PRISM) for 260 teens aged 12-17 with chronic musculoskeletal pain. The goal was to see if coaching improves daily function, reduces distress, and lessens pain compared to usual care. Participants completed surveys and coaching sess…

This study tested a short behavioral sleep program called Sleep Well! for children ages 1 to 5 in urban primary care clinics. Researchers wanted to see if families would find it useful and stick with it. The program included healthy sleep advice and tips to improve bedtime habits…

This study looked at whether taking an NAD+ precursor (a vitamin-like supplement) along with exercise training can improve aerobic capacity (how well the body uses oxygen during exercise) in people with Friedreich's ataxia. The trial included 75 participants aged 10 to 40. Resear…

This pilot study tested the drug elamipretide in 20 people with Friedreich ataxia to see if it could safely improve vision loss. Participants received either a low or high dose, and researchers measured changes in eyesight. The study is complete, but results are not yet available…

This study tested a new type of mobility training (called dynamic supported mobility) for infants and toddlers with cerebral palsy. The goal was to see if it helps improve movement and balance better than standard care. 42 children aged 12 to 36 months took part. The study compar…

This study followed 60 infants at high risk for cerebral palsy from birth to 18 months to see how they learn to move. Researchers used wearable sensors and a robotic crawler to measure leg movements, crawling, and walking. The goal was to understand how motor skills develop or ar…

This study looked at whether an informational video could help parents and teens better understand genetic testing after a new cancer diagnosis. About 355 families from a children's hospital took part. The goal was to see if the video was acceptable and improved knowledge about g…

This study looked at what makes it hard for new moms with postpartum depression to get mental health care, especially online. Researchers interviewed 10 women and then tested a virtual patient navigation program with 26 moms over 2 months. The goal was to see if the program was e…

This study tested whether digital care plans and text message reminders help families of children with cancer predisposition syndromes better understand their child's condition. Researchers enrolled 177 parents and measured changes in knowledge and how acceptable the digital tool…

This study tested a program to help Black youth who came to the emergency room with suicidal thoughts get connected to mental health care. Researchers adapted an existing program and used patient navigators to support families. The goal was to see if this approach increases the n…

This study looked at 513 children with a severe lung condition called ARDS to find different subtypes of the disease. Researchers collected blood samples to measure proteins and gene activity. The goal was to better understand the disease and help design more targeted treatments …

This study looked at how to keep mental health programs running in 12 urban public schools with limited resources. Researchers compared two support models for school counselors and staff delivering evidence-based programs like Coping Power and CBT for anxiety. Over three years, t…

This study tested a remote training program to help school staff in rural areas deliver mental health support to students. Researchers worked with 174 school staff to see if the training was practical and effective. The goal was to improve access to care in places with few mental…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study tested a resource package designed to help caregivers use behavioral interventions for children showing hyperactive, inattentive, or impulsive behaviors. Twenty caregivers of children in grades K-5 in the Philadelphia area used the package at home. The research team co…

This study followed 89 children who finished chemotherapy for acute lymphoblastic leukemia (ALL) to see how their immune systems bounced back. Researchers measured antibody levels for vaccine-preventable diseases and tracked infections during the first year off treatment. The goa…

This study tested a program called Care Coordination after Preterm Birth (CCAPB) to see if it helps mothers who had a preterm baby. The program provides extra support with healthcare access and well-being for six months. Researchers measured how acceptable the program was and its…

This study tested whether giving doctors automated reports on their antibiotic prescribing habits could improve how often they follow official guidelines. Researchers looked at over 26,000 patients with pneumonia, ear infections, or sore throat. They compared antibiotic use befor…

This study looked at whether whole genome sequencing (a complete read of a person's DNA) can help diagnose leukodystrophies, a group of rare brain diseases that are hard to identify. Researchers enrolled 236 children with white matter abnormalities on brain scans but no known gen…

This study measured levels of the laxative PEG 3350 and its breakdown products in the blood and urine of 158 children who were already taking it, compared to children not taking it. The goal was simply to learn how the body processes this medicine, not to change any treatments. R…

This study tested a new digital tool that helps doctors screen and treat teens for sexually transmitted infections (STIs). Researchers wanted to see if the tool was easy to use and acceptable to doctors, teens, and parents. About 190 participants took part, including doctors, tee…