Children's Hospital Of Philadelphia

This study tests a stem cell transplant method for people with acquired or inherited bone marrow failure. Donor stem cells are specially processed to remove certain immune cells, which may lower the risk of graft rejection and graft-versus-host disease. The goal is to see if this…

This pilot study tests a fludarabine-based drug regimen to prepare children with bone marrow failure syndromes for a bone marrow transplant from a matched sibling donor. The goal is to help the donor cells successfully take root while reducing serious side effects. The study incl…

This study tests a milder chemotherapy and immune-suppressing regimen before a stem cell transplant for children and young adults with non-malignant blood disorders like sickle cell disease or immune deficiencies. The goal is to safely achieve donor cell engraftment with fewer si…

This phase 2 trial tests the drug trametinib in 45 people aged 2 months to 30 years with vascular anomalies caused by changes in the Ras/MAPK pathway. Participants take trametinib daily for up to 3 years. The study measures whether the drug shrinks lesions, improves quality of li…

This study tests the drug alpelisib, already approved for some breast cancers, in people aged 2 months to 30 years with certain blood vessel growth disorders caused by PIK3CA or TIE2 gene changes. Participants take the drug for 2-3 years and attend up to 16 clinic visits to check…

This study tests whether online training and regular feedback reports can help doctors prescribe fewer antibiotics for common infections like ear infections, strep throat, sinusitis, and pneumonia in children. About 420 children aged 6 months to 12 years are included. The goal is…

This pilot study looks at whether adding a community health worker to the diabetes care team helps children recently diagnosed with type 1 diabetes. The health worker will visit the child's home, help set health goals, and address social needs like food or housing. The study will…

This pilot study is testing whether a procedure called endoscopic sleeve gastroplasty (ESG) is safe and helpful for weight loss in 10 obese adolescents aged 12-17. Instead of traditional weight-loss surgery, doctors use a device inserted through the mouth to stitch the stomach sm…

This Phase II trial tests a stem cell transplant from unrelated or partially matched family donors for children and young adults with severe immune deficiencies. The stem cells are specially processed to remove certain immune cells, aiming to reduce complications. The goal is to …

This study tests a stem cell transplant method that removes certain immune cells (T and B cells) from donated stem cells before giving them to patients with blood cancers like leukemia or lymphoma. The goal is to help the new cells grow (engraft) while reducing the risk of graft-…

This pilot study tests a procedure called FETO in 14 unborn babies with severe left congenital diaphragmatic hernia (CDH), a birth defect where abdominal organs push into the chest and stunt lung growth. Doctors place a tiny balloon in the baby's windpipe via fetoscopy to trap lu…

This study tests a therapy program called MIO-CPP for mothers recovering from substance use disorders and their young children (up to age 5). The program combines individual therapy for mothers and joint mother-child sessions to strengthen their bond and improve child well-being.…

This study looks at whether contrast-enhanced ultrasound (CEUS) can accurately detect internal abdominal injuries in children under 8 who have experienced blunt trauma, such as from falls or car accidents. Researchers will compare CEUS results to standard CT scans in 120 children…

This study tests whether a 16-session program called HOPS can help 6th to 8th graders with ADHD improve their organization, time management, and planning skills. Researchers are working with 240 students and their teachers in real school settings to see if the program works outsi…

This study tests whether giving both caregivers and teachers a resource package for managing hyperactive, inattentive, or impulsive behaviors helps children more than giving it only to teachers. About 100 children in grades K-5 will take part, and researchers will measure how fea…

This pilot study tests whether daily meditation can improve recovery for children and adults having surgery for kidney stones. Participants will be randomly assigned to either a meditation group or a control group. Those in the meditation group will practice a daily 20-minute gui…

This study uses special brain scans (MRS) to measure two natural chemicals, GABA and glutathione, in people with Friedreich's Ataxia (FRDA). Researchers want to see if these chemicals can serve as reliable markers of the disease and how they change after taking the drug Omaveloxo…

This study looks at whether a special computer tool can help doctors better care for children aged 5 to 18 with mild traumatic brain injury (concussion). The tool predicts which kids are at risk for long-lasting symptoms and suggests early referral to specialists. Researchers wil…

This pilot study tests a training program called PriCARE that teaches foster parents positive parenting skills like praise and effective limit-setting. The goal is to see if the program is practical and helpful for foster families. Researchers will enroll 60 foster caregivers and…

This study tests whether ultrasound can predict difficult breathing tube placement in newborns and infants up to 1 year old. Researchers will take six ultrasound measurements of the upper airway after anesthesia but before intubation. The goal is to see if these measurements can …

This study looks at whether ultrasound can accurately measure stomach contents in children with traumatic injuries who need emergency surgery. Researchers will compare ultrasound estimates with actual stomach fluid drained after intubation. The goal is to better predict aspiratio…

This study looks at ways to reduce the overuse of continuous pulse oximetry (a device that measures oxygen levels) in children hospitalized with bronchiolitis who are not on supplemental oxygen. Researchers are testing educational outreach and feedback strategies across multiple …

This study uses special MRI scans to measure how well muscles produce energy in people with mitochondrial disease. Researchers hope to learn more about the condition and develop a new tool to help diagnose and track it. The study involves 230 participants aged 7 to 75 with suspec…

This study tests a 'discharge stewardship bundle' to help doctors prescribe the right antibiotics for the right duration when children leave the hospital. Over 1,100 children with pneumonia, urinary tract infections, or skin infections will be followed. Doctors receive feedback r…

This study is testing whether a simple urine test can detect signs of kidney transplant rejection in children. Researchers are looking for specific molecules in urine that signal the body is attacking the new kidney. If the test works, it could help doctors spot problems early wi…

This study compares two different approaches to reduce the number of unnecessary blood cultures (tests for infection) in 8 pediatric intensive care units (PICUs). About 8 clinicians will take part to see which strategy works better at lowering blood culture rates while keeping pa…

This study was designed to find out what parents of children aged 8-12 with type 1 diabetes need to better use insulin pumps and continuous glucose monitors. Researchers planned to use this information to create an app to support parents and improve diabetes management. However, …

This research study aims to understand why some people develop food allergies and others outgrow them. Researchers at Children's Hospital of Philadelphia will collect blood samples from 5,300 people (ages 1 month to 65 years) with and without food allergies to study immune cells …