Children's Hospital Of Philadelphia

This pilot study looks at whether adding a community health worker to the care team helps children (under 17) with newly diagnosed type 1 diabetes. The goal is to see if it improves blood sugar control, reduces hospital stays, and lowers healthcare costs. The study involves 28 ch…

This study tests a program that combines two types of therapy to help mothers recovering from substance use disorders and their young children (up to age 5). The goal is to improve the parent-child relationship, reduce stress, and keep children safe and out of foster care. About …

This study tested a procedure called FETO for babies with a severe form of congenital diaphragmatic hernia (CDH), a birth defect where organs move into the chest and stop the lungs from growing. The procedure involves placing a tiny balloon in the baby's windpipe while still in t…

This study tests a special stem cell transplant for children and young adults (ages 0-25) with life-threatening immune system problems. Doctors remove certain cells from donated stem cells to lower the risk of rejection and side effects. The goal is to see if this approach helps …

This study tests a stem cell transplant from unrelated or partially matched donors for people with blood cancers like leukemia, lymphoma, or myelodysplasia. The donated cells are specially treated to remove certain immune cells, which may help the transplant take hold and reduce …

This study tests the drug alpelisib (already approved for some breast cancers) in people aged 2 months to 30 years with rare blood vessel growth disorders caused by specific gene changes. Participants take the drug for at least 2 years, and researchers measure improvement using s…

This study tests a milder chemotherapy regimen before a bone marrow or cord blood transplant in children and young adults (ages 6 months to 25 years) with non-cancerous blood disorders like sickle cell disease, thalassemia, and immune deficiencies. The goal is to see if this gent…

This study tests the drug trametinib, already approved for melanoma, in people aged 2 months to 30 years with rare blood vessel growth problems caused by a specific gene pathway. The goal is to see if the drug can shrink abnormal vessels and improve quality of life. Participants …

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) in 10 obese adolescents aged 12-17. Instead of surgery, doctors use a flexible tube to reduce stomach size, helping with weight loss. The goal is to see if it's safe and works long-term to lower weight and i…

This study looks at whether a special ultrasound (contrast-enhanced ultrasound) can accurately find internal belly injuries in children under 8 who have had a hard hit to the belly, like from a fall or car crash. The goal is to see if this method works as well as a CT scan, which…

This study tests a program called PRISM that teaches teens aged 12-17 with long-lasting muscle or joint pain how to build resilience. About 260 teens and their caregivers will take surveys and either get coaching or usual care. The goal is to see if coaching reduces disability, d…

This study tests whether giving both caregivers and teachers a behavioral support toolkit helps children with hyperactive, inattentive, or impulsive behaviors. About 100 children in grades K-5 will take part, with some families getting the toolkit and others only the teacher gett…

This pilot study is testing whether a daily 20-minute meditation program, done for 2-4 weeks before and 2 weeks after kidney stone surgery, can improve pain and anxiety in patients aged 12 and older. Half of the 50 participants will learn meditation, while the other half will rec…

This study compares two approaches to reduce how often blood cultures are taken in 8 pediatric intensive care units (PICUs). It involves 8 clinicians and aims to see if these strategies lower blood culture rates without harming patient safety. The focus is on understanding which …

This study looks at whether a stomach ultrasound can accurately measure the amount and type of stomach contents in children (ages 0-17) who have been injured and need urgent surgery. The goal is to help doctors choose the safest way to manage the child's airway during anesthesia …

This study looks at whether a simple, no-radiation throat ultrasound can help doctors predict when placing a breathing tube in a baby (under 1 year old) will be hard. Researchers will watch 180 babies during planned surgeries to see if the ultrasound matches actual tube placement…

This study is looking at the biological and genetic reasons why some people develop food allergies and others outgrow them. Researchers will collect blood samples from up to 5,300 people, including those with food allergies, their family members, and healthy volunteers. The goal …

This study looks at whether a urine test can help doctors check the health of a kidney transplant in children. Researchers will measure certain markers in urine samples from 445 kids aged 2 to 18 who have had a kidney transplant. The goal is to find a noninvasive way to detect re…

This study uses special MRI scans to measure how muscles produce energy in people with mitochondrial disease. Researchers will scan the legs of 230 participants aged 7 to 75 who have suspected or confirmed mitochondrial disease. The goal is to better understand the disease and de…

This study aimed to find out what parents of children aged 8-12 with type 1 diabetes need to better use insulin pumps and continuous glucose monitors. The goal was to use this information to create a smartphone app to help parents manage their child's diabetes more effectively. T…

This study looks at how well a positive parenting program works for foster caregivers. About 60 foster parents of children aged 1.5 to 6 years will take part. The goal is to see if the program helps parents be more caring and less harsh, and to find the best ways to offer this tr…

This study looks at whether the Homework, Organization, and Planning Skills (HOPS) program helps middle school students who struggle with organization, time management, and planning, often due to ADHD. About 240 students in grades 6-8 will work with school staff to learn these sk…

This study tests a set of guidelines called a 'discharge stewardship bundle' to help doctors prescribe antibiotics more appropriately for children with pneumonia, urinary tract infections, or skin infections when they leave the hospital. Over 1,100 children and their families fro…

This study looks at whether a special computer tool can help doctors better manage children aged 5 to 18 with mild traumatic brain injury (concussion). The tool predicts which kids are at risk for long-lasting symptoms and suggests early referral to specialists. Researchers will …

This study looks at ways to help doctors prescribe fewer antibiotics for common respiratory infections in children, like ear infections, strep throat, sinusitis, and pneumonia. Researchers will track antibiotic use in over 400 children seen at primary and urgent care clinics. The…

This study looked at how to reduce the overuse of continuous pulse oximetry (a clip that measures oxygen levels) in children hospitalized with bronchiolitis who are breathing room air and don't need extra oxygen. Over 9,000 children were observed to see which strategies best help…