PANCREAS CANCER

This early-stage trial is testing a new combination of chemotherapy drugs and high-dose vitamin C, followed by an infusion of the patient's own stem cells, in people with metastatic pancreatic or breast cancer. The goal is to see if this approach is safe and can overcome drug res…

This early-phase study tests a new drug, QXL138AM, in about 100 people with advanced solid tumors (like ovarian, pancreatic, lung, and breast cancers) or multiple myeloma. The main goal is to check the drug's safety and find the best dose. Researchers will also look for signs tha…

This early-phase study tests an experimental drug called MGC026 in 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. Participants receive the drug by I…

This study tests a drug called axelopran in people with advanced breast, lung, pancreas, or prostate cancer who are taking opioids for pain. The goal is to see if axelopran can slow tumor growth, improve bowel function, and reduce inflammation. About 34 participants will take the…

This early-phase study tests a new gene therapy for people with pancreatic cancer that has returned after standard treatment. The therapy uses a patient's own immune cells, modified to target a protein called B7-H3 on cancer cells, and includes a safety switch to control side eff…

This study tests a new drug, KESONOTIDE™, in adults with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The goal is to check the drug's safety and how the body processes it. About 80 participants will receive the drug in two …

This study tests whether adding two targeted drugs (defactinib and avutometinib) to a precise type of radiation therapy can help people with advanced pancreatic cancer live longer without their cancer growing. About 36 adults whose cancer is locally advanced or borderline resecta…

This study tests whether adding the immunotherapy drug sintilimab to standard chemotherapy and radiation can help people with inoperable pancreatic cancer live longer without their cancer growing. The trial will enroll 25 adults who have not had prior treatment for their advanced…

This study tests whether injecting a medical glue (N-butyl-2-cyanoacrylate) into the pancreas during surgery can prevent dangerous fluid leaks after the pancreas is reconnected. About 90 people with pancreatic or nearby cancers who are at high risk for leaks will be randomly assi…

This phase 3 trial tests whether a multi-disciplinary treatment plan can help people with pancreatic cancer that has spread to only a few other places in the body live longer without the disease getting worse. About 80 adults with this condition will receive either standard care …

This early-phase trial is testing whether adding tumor treatment fields (TTF) — a device that delivers low-intensity electric fields to disrupt cancer cell division — to a three-drug chemotherapy regimen can safely control metastatic pancreatic cancer. About 40 adults with pancre…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The treatment uses the patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Participants receive these cells through an …

This study tests if injecting a medical glue into the pancreas during surgery can help prevent dangerous leaks. The surgery removes part of the pancreas and reconnects it to the intestine. The glue is meant to strengthen that connection. About 30 adults with pancreatic or nearby …

This study tests a high-dose, short-course radiation treatment for people with locally advanced pancreatic cancer that cannot be surgically removed. The goal is to see if this approach can control tumor growth in the treated area for at least two years. The trial will enroll 30 p…

This early-stage study tests a new treatment using a patient's own immune cells, modified to target a protein called CEA found on certain cancer cells. It is for adults with advanced lung, stomach, colon, rectal, esophageal, or pancreatic cancer who have not responded to standard…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This study tests whether giving personalized targeted therapy based on a patient's tumor profile can delay or prevent pancreatic cancer from coming back after surgery. It enrolls 40 adults whose cancer was removed but who have a high risk of recurrence. Participants receive treat…

This study is testing whether adding a device that sends low-intensity electric fields (tumor treating fields) to standard radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. About 48 participants will receive radiation for five days and use t…

This study tests whether adding a medical glue (Glubran 2) to the surgical connection in the pancreas can prevent a serious complication called pancreatic fistula, which is a leak of digestive fluids. About 100 adults undergoing pancreas removal for cancer will be randomly assign…

This study tests a device that uses sound waves (histotripsy) to break apart pancreatic tumors without surgery. It involves 50 adults with advanced pancreatic cancer that cannot be removed. The main goal is to check if the procedure is safe and to track any complications within 3…

This early-stage study tests whether adding a procedure called irreversible electroporation (IRE) to standard chemotherapy can help control locally advanced pancreatic cancer. IRE uses short electric pulses to destroy cancer cells. The study will enroll 20 adults with stage III p…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control advanced solid tumors like lung, pancreas, and colorectal cancers. The trial involves 54 adults whose current…

This study is testing a new type of radiation therapy called SMART, which uses MRI scans to guide treatment in real time. It aims to see if this approach is safe and effective for several cancers, including pancreas, lung, and prostate cancer. About 400 adults with tumors smaller…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study tests a software called Lipidica 1.0 that analyzes fats in the blood to help screen for pancreatic cancer. It involves 419 people at high risk due to family history or genetic factors. The goal is to see if the software can accurately tell who has cancer and who does n…

This study is testing a new, more detailed MRI scan of the pancreas to find cancer earlier in people at high risk. About 79 participants with a strong family history or certain gene changes will get the new scan. The goal is to see if this scan works better than the usual one for…

This study tests if a smartphone app can help people at high risk of cancer eat less ultra-processed foods and improve their overall diet. About 170 participants will either get the app plus nutrition education or just education alone. The goal is to see if the app helps them mak…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study collects tumor and normal tissue samples from up to 1,800 people with solid tumors who are already scheduled for surgery or biopsy at the NIH Clinical Center. The samples are used to identify new molecular targets for cancer therapies. Participants also provide blood s…

This study looks at certain proteins called convertases in pancreatic tumor samples from 50 patients. Researchers want to see if the levels of these proteins are linked to the immune cells around the tumor. The goal is to find new ways to predict how the disease will progress, no…

This study focuses on improving the quality of care for Black patients newly diagnosed with gastrointestinal cancer. It helps ensure patients get the right biomarker tests, offers assistance in joining other clinical trials, and provides educational materials to improve understan…

This study collects blood samples from 30 adults with pancreatic cancer to create a research database. The goal is to store these samples and link them to patient health records for future studies on biomarkers. No new treatments are tested; this is purely for building a research…

This study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand which cancers might respond to a future CAR T-cell therapy and to store participants' own immune cells for potential …

This study is for people with locally advanced cervical or pancreatic cancer who are scheduled to receive chemoradiotherapy. Researchers will collect tumor samples, blood, and imaging data before, during, and after treatment to track how the tumor's environment changes over time.…

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study follows 20,000 people who have a family history of pancreatic cancer or carry certain gene changes that raise their risk. Researchers will track them over time to learn how to detect pancreatic cancer earlier and possibly prevent it. The goal is to improve survival by …

This study is developing and testing a mobile app designed to help Black people with pancreatic cancer learn about and discuss clinical trials with their doctors. The goal is to increase their participation in these trials, which is currently much lower than for White patients. R…

This study follows 5,000 adults with pancreatic cysts to understand how these cysts behave over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and samples, but no new treatment is …

This study is for people with pancreatic cancer that can be surgically removed. Researchers will test blood samples for tiny pieces of tumor DNA (ctDNA) to see if they can predict how long patients live and how the disease responds to chemotherapy. The goal is to learn more about…

This study is looking at whether a special DNA test (called ctDNA) done on blood or stool samples can help doctors better manage patients with cancers of the digestive tract, such as pancreas, colon, or bile duct cancer. About 100 adults with these cancers will provide samples, a…

This study aims to find better ways to detect pancreas cancer early in people who are at high risk due to family history or certain gene mutations. Researchers will collect and analyze pancreatic juice and cyst fluid from 9,000 participants to look for markers that signal early c…