PANCREAS CANCER

This study tests whether a personalized, adjustable treatment plan before surgery can help more people with pancreatic cancer become eligible for surgery. Researchers aim to increase the surgery rate from the usual 60% to 80% in 32 participants with resectable or borderline resec…

This early-phase study tests whether using electric pulses to deliver chemotherapy (bleomycin) to the area where a pancreatic tumor was removed can lower the chance of cancer coming back. About 10 to 20 adults with resectable pancreatic cancer will receive this treatment right af…

This early-phase study tests an experimental drug called MOMA-313, given alone or with another drug (olaparib), in people with advanced solid tumors that have a specific DNA repair problem (HR deficiency). The goal is to find a safe dose and see if the drug shrinks tumors. About …

This study tests a new combination of drugs (avutometinib and defactinib) added to standard chemotherapy for people with advanced pancreatic cancer that has spread. The goal is to see if the new combo is safe and can shrink tumors better than chemo alone. About 40 adults who have…

This study tests whether adding a drug called defactinib to targeted radiation therapy can help control advanced pancreatic cancer better than radiation alone. About 42 people with inoperable pancreatic cancer will take part. The goal is to see if the combination slows cancer gro…

This early-stage study tests a new drug, TORL-2-307-ADC, in 163 people with advanced solid tumors like stomach, pancreas, or esophageal cancer. The goal is to find a safe dose and see if the drug can shrink tumors. Participants must have measurable disease and be well enough for …

This early-phase study tests whether adding a new drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer. About 19 adults with confirmed advanced disease are taking part. The main goal is to check for side ef…

This study tests a precise, high-dose radiation technique called SBRT given after surgery for pancreatic cancer. The goal is to see if it lowers the chance of the cancer coming back near the surgery site and helps people live longer. About 50 adults with certain high-risk feature…

This study tests a new drug called 9-ING-41, which targets a protein (GSK-3β) that helps cancer grow. It is for adults with advanced cancers that have not responded to standard treatments. The drug is given alone or with chemotherapy to see if it is safe and helps shrink tumors o…

This early study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop pancreatic cancer growth. Cancer cells need lots of cholesterol to grow, and this approach aims to starve them. The trial inc…

This study tests whether giving a precise dose of radiation directly to the tumor during surgery can help people with pancreatic cancer that has grown into nearby blood vessels. Participants had already received chemotherapy and standard radiation before the procedure. The main g…

This study looks at whether ketorolac, a common anti-inflammatory drug, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (severe weight loss). About 28 participants will take the drug four times daily for fi…

This study looks at whether a supervised exercise program is practical and safe for people with pancreatic cancer. Sixteen participants will attend exercise sessions before their main treatment. The goal is to see if at least half of them can stick with the program, and to monito…

This early-phase study tests whether psilocybin (the active ingredient in magic mushrooms) can help reduce depression and anxiety in people with advanced, incurable gastrointestinal cancers. The study enrolls 24 adults aged 19-85 living near Omaha, NE, who have a family member al…

This study enrolls 200 people with pancreatic cancer to collect tumor tissue, blood, and stool samples. Researchers will analyze the genetic makeup of each tumor and grow mini-tumors in the lab to test which drugs work best. The goal is to see if this personalized approach can he…

This study aims to understand how the bacteria living in your body (the microbiome) influence recovery after surgery for pancreatic or related cancers. Researchers will collect saliva, blood, stool, and tumor samples from 200 adult patients before and after surgery. The goal is t…

This study explores whether ultrasound images analyzed by a special computer program can accurately measure the size of liver tumors in people with pancreatic or gastrointestinal cancer that has spread to the liver. Participants will have both a routine contrast-enhanced CT scan …

This study looks at a new approach to genetic testing for people with ovarian, prostate, or pancreas cancer. Instead of referring patients to a genetic counselor, doctors offer the test directly, and counselors share results by phone. The goal is to see how this affects patient d…