Promising new cocktail targets tough pancreatic cancer
NCT ID NCT05669482
First seen Nov 01, 2025 · Last updated Jun 14, 2026 · Updated 32 times
Summary
This study tests a new combination of drugs (avutometinib and defactinib) added to standard chemotherapy for people with advanced pancreatic cancer that has spread. The goal is to see if the new combo is safe and can shrink tumors better than chemo alone. About 40 adults who have not had prior treatment for their metastatic pancreatic cancer will take part.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York, 10016, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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New York Presbyterian/Weill-Cornell Medical Center
New York, New York, 10021, United States
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UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94158, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Michigan Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Utah Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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Virginia Mason Medical Center
Seattle, Washington, 98101, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.