MYELOPROLIFERATIVE NEOPLASM

This study tests a vaccine designed to protect people who have had a stem cell transplant from a common virus called CMV. The virus can cause serious illness in those with weak immune systems. The vaccine uses a harmless virus to teach the body to fight CMV, aiming to reduce infe…

This study tests a vaccine called Triplex to prevent cytomegalovirus (CMV) infection in adults who have received a stem cell transplant. CMV can cause serious illness in people with weakened immune systems. The vaccine uses harmless pieces of CMV DNA to help the body build immuni…

This study tests whether adding the drug pomalidomide to standard chemotherapy helps people with a certain type of acute myeloid leukemia (AML) that is linked to prior blood disorders or cancer treatment. About 50 adults with newly diagnosed AML will be randomly assigned to get e…

This study tests if luspatercept can help people with certain types of MDS or MDS/MPN need fewer blood transfusions for anemia. Six adults with low- or intermediate-risk disease and a specific gene mutation are receiving the drug plus standard care. The goal is to see if they can…

This study was designed to test a new combination of two drugs (ASTX727 and ASTX029) for people with certain types of blood cancers (MDS or MDS/MPN) that have a RAS gene mutation. The goal was to find a safe dose and see if it could control the disease. However, the study was wit…

This study is testing a combination of three drugs (azacitidine, venetoclax, and pevonedistat) in adults with a newly diagnosed, aggressive form of acute myeloid leukemia (AML) that is related to prior cancer treatment or other blood disorders. The goal is to find the best dose a…

This early-phase study tests an experimental drug called INCB057643, given alone or with the standard drug ruxolitinib, in adults with myelofibrosis or other advanced blood cancers. The main goals are to check safety and see if the drug can reduce spleen size, which is a key sign…

This early-phase study tests a new targeted drug (PVEK) combined with standard chemotherapy for adults with aggressive forms of acute myeloid leukemia and related blood cancers. PVEK works like a smart bomb, attaching to cancer cells and delivering chemotherapy directly to them. …

This study tests a combination of two drugs, azacitidine and quizartinib, for adults with myelodysplastic syndromes or related blood cancers that have specific gene changes (FLT3 or CBL). The goal is to find the best dose and see how well the drugs control the cancer. About 30 pe…

This early-phase study tests whether adding specially treated immune cells (called veto cells) from a donor can help stem cell transplants work better in people with blood cancers like leukemia or lymphoma. The goal is to help the donor cells grow without causing severe graft-ver…

This early-phase study tests the safety of combining three drugs—navitoclax, venetoclax, and decitabine—for people with advanced myeloid blood cancers like acute myeloid leukemia and myelofibrosis. The goal is to find the safest effective dose and see how well the combination wor…

This study tests a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and CNL). The goal is to see if it can shrink enlarged spleens and improve blood counts. Participants take the drug by mouth and are monitored for response and side effects.

This phase 2 trial tests whether adding venetoclax to ASTX727 (a two-drug pill) works better than ASTX727 alone for adults with chronic myelomonocytic leukemia or related bone marrow cancers with excess blasts. About 132 participants will receive either the combination or ASTX727…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections while still preventing graft-versus-host disease (a condition where donor cells attack the patient's body). About 3…

This study tests whether adding a drug called cyclophosphamide after a stem cell transplant can lower the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The trial includes 35 adults with various blood cancers or sever…

This study tests a fast, motion-resistant brain MRI technique called Magnetic Resonance Fingerprinting (MRF) in children, teens, and young adults with acute leukemia. The goal is to see if the scan can detect brain changes caused by chemotherapy drugs that enter the brain. Partic…

This study looks at how often people with certain blood cancers or related conditions have an acquired form of pyruvate kinase deficiency, a red blood cell enzyme problem. Researchers will take a single blood sample from 100 participants to check enzyme activity and gene changes.…

This study is an observational registry for 572 Italian patients with Philadelphia-negative myeloproliferative neoplasms (MPN). Its main goal is to collect information on how the disease and its treatments impact patients' quality of life, symptoms, and daily functioning. No expe…