METASTATIC RENAL CELL CARCINOMA

This study is testing a new medicine called PF-08634404 for adults with advanced kidney cancer that has spread. Researchers want to see if the medicine is safe and effective when given alone or with other cancer drugs. The study is recruiting 224 adults who haven't received any t…

This trial is for people whose kidney cancer has spread. It aims to find out if removing the original kidney tumor with surgery, on top of standard immunotherapy drug combinations, helps patients live longer than using the drugs alone. About 364 participants will be randomly assi…

This study is testing a more flexible way to give the cancer drug cabozantinib to people with advanced kidney cancer or neuroendocrine tumors. The goal is to see if adjusting the dose up or down based on how patients feel can help them stay on treatment longer with fewer severe s…

This study is testing whether a digital app that lets patients report their symptoms weekly helps doctors better manage side effects for people taking two cancer drugs (cabozantinib and nivolumab) for advanced kidney cancer. It involves 83 adults who are starting this specific dr…

This study is for people with advanced kidney cancer whose immunotherapy is working for most of their body, but a few tumors (1-5) have started growing again. It tests whether using very precise, high-dose radiation to treat just those few growing tumors can help patients continu…

This study is testing whether combining two existing cancer drugs—pembrolizumab and aldesleukin—works better than either alone for adults with advanced melanoma or kidney cancer that has stopped responding to standard treatments. The goal is to see if this combination can shrink …

This early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…

This study aims to find the best radiation method for treating cancer that has spread to the brain. It compares giving one large radiation dose versus spreading the same total radiation over three smaller treatments. Researchers want to see which approach better controls the brai…

This study is for people with advanced kidney cancer that has spread and is not recommended for surgery. It tests whether adding a short, highly focused course of radiation to the main kidney tumor, while patients receive standard immunotherapy drugs, helps control the cancer bet…

This study is testing a new combination of three drugs to see if they can safely control advanced kidney cancer that has spread. The trial will enroll about 25 adults with specific types of advanced kidney cancer who have not yet received treatment for their metastatic disease. R…

This study is testing a strategy to help patients whose kidney cancer has started to spread to just a few new spots while their current medications are still controlling the rest. The goal is to use very precise, high-dose radiation to destroy these few new spots. Researchers hop…

This study is for people with advanced kidney cancer that has come back after they received standard post-surgery treatment. It aims to see if a new drug called zanzalintinib, taken alone or combined with an immunotherapy drug (nivolumab), can help control the cancer. About 70 pa…

This study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…

This study is testing whether following a strict high-fat, low-carbohydrate (ketogenic) diet is safe and feasible for patients with advanced melanoma or kidney cancer who are receiving immunotherapy. Researchers want to see if changing the body's main fuel source from sugar to fa…

This study is testing whether combining two drugs, abemaciclib and cabozantinib, is safe and effective for people with advanced kidney cancer that has spread and has stopped responding to standard treatments. Researchers will first find the safest dose and then see how well the c…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…