LYNCH SYNDROME

This study is testing a blood test (called a liquid biopsy) to see how well it can find colorectal cancer, pre-cancerous growths (adenomas), and Lynch syndrome-related cancers early. Researchers will enroll 1,200 people who have already had a colonoscopy. The goal is to see if th…

This study tests a new, inexpensive capsule tool that is attached to a string and inserted into the lower gut to take real-time pictures without sedation. It aims to see if the device can capture clear images of the lower gastrointestinal tract in 30 adults, including healthy vol…

This study tests if a menstrual cup can collect enough uterine tissue to screen for endometrial cancer in women with Lynch syndrome, who have a higher risk. Participants will use a cup at home and also get a standard biopsy, then compare results. If it works, it could offer a pai…

This study is testing a new stool DNA test to see if it can find colorectal cancer or pre-cancerous growths in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will collect blood and stool samples from 950 adults with Lynch syndrome or early-on…

This study is testing whether a urine test that looks for tumor DNA can find bladder and urinary tract cancers early in people with Lynch syndrome, a genetic condition that raises cancer risk. About 200 participants aged 50–75 will provide urine samples and be followed for one ye…

This study looks at whether people with Lynch syndrome can use a self-collected vaginal swab at home to find early signs of uterine cancer. Researchers want to see if participants are willing and able to do the test and find it acceptable. The study involves 30 adults with Lynch …

This early-stage study tests a new vaccine made from a person's own immune cells to see if it can prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine is designed to train the immune system to recognize and attack cells that might…

This study tests whether naproxen or aspirin can increase immune cells in the colon to help prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. About 40 adults will take one of these drugs or a placebo for a short time. Researchers will chec…

This study tests if a smartphone app can help people at high risk of cancer eat less ultra-processed foods and improve their overall diet. About 170 participants will either get the app plus nutrition education or just education alone. The goal is to see if the app helps them mak…

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a pill-sized camera) to screen for pre-cancerous growths or cancer in the small intestine. The goal is to see how well this camera test finds these lesions compared …

This study compares an artificial intelligence system called CAD-EYE to the standard dye-spray technique for finding precancerous growths during colonoscopy in people with Lynch syndrome. Lynch syndrome is a genetic condition that greatly increases the risk of colorectal cancer. …

This study is for people with Lynch syndrome, a genetic condition that raises the risk of several cancers, including a rare type of small bowel cancer. Researchers will use a swallowable camera (videocapsule endoscopy) to take pictures of the small intestine and track how often a…

This research study aims to discover new genes that may cause cancer to run in families. It will enroll up to 1,500 people from families where multiple members have had childhood cancers or related conditions. Participants provide blood samples and health information, which are s…

This study is creating a large, long-term database of medical information and biological samples from people with many types of cancer, those at high risk, and healthy volunteers. Researchers will use this resource to study what causes cancer, how it progresses, and how to better…

This study looks at families in Switzerland who carry genes that raise the risk of breast, ovarian, colorectal, or endometrial cancers. Researchers will survey both the person with the gene mutation and their close relatives to understand how many get tested and what barriers the…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used for future research to better understand how cancer grows and responds to treatment. No direct treatment is given; the goal is …

This study offers free genetic testing to the general public to find people with inherited cancer syndromes, like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500…

This study looks at how the immune system monitors and fights early cancer cells in people with Lynch syndrome, a genetic condition that raises the risk of colorectal and other cancers. Researchers will follow 300 adults with Lynch syndrome during their regular cancer screenings.…

This study aims to find better ways to detect pancreas cancer early in people who are at high risk due to family history or certain gene mutations. Researchers will collect and analyze pancreatic juice and cyst fluid from 9,000 participants to look for markers that signal early c…