LYNCH SYNDROME

This study tests a vaccine called Nous-209 in 45 people with Lynch syndrome, a genetic condition that raises the risk of colon and other cancers. The vaccine is made from man-made copies of proteins that cancer cells produce, aiming to teach the immune system to recognize and att…

This study aimed to test a combination of two immunotherapy drugs (nivolumab and ipilimumab) in children, adolescents, and young adults with cancers that returned or didn't respond to treatment and had many genetic mutations. The goal was to see if the drugs could shrink or stabi…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy helps prevent cancer from returning in people with stage III colon cancer that has a specific DNA repair problem (dMMR). About 712 participants received either chemotherapy alone or chemo…

This early-stage trial is testing the safety and potential benefit of pembrolizumab, an immunotherapy drug, in 71 children whose brain tumors (like DIPG, high-grade gliomas, or medulloblastoma) have come back or not responded to standard treatments. The drug works by helping the …

This study tests a program to help people with BRCA or Lynch syndrome mutations—and their families—lose weight and adopt healthier habits like better diet and more exercise. The goal is to see if these lifestyle changes can lower their risk of developing cancer. About 384 partici…

This study tests a special vaccine (Tri-Ad5) plus an immune booster (N-803) to see if it can prevent colon and other cancers in people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine trains the immune system to recognize and destroy precancerous cell…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which programs work best to reduce cancer risk. About 337 participants…

This study enrolls 200 adults with hereditary cancer syndromes (like BRCA or Lynch syndrome) who live in rural areas. Participants receive a personalized care plan and regular check-ins to help them follow cancer screening and risk-reduction guidelines. The goal is to see if this…

This study is creating a large database of people at high risk for pancreatic cancer, including those with cysts, genetic conditions, or other risk factors. The goal is to track their health over time to find better ways to detect the disease early or even prevent it. About 317 p…

This study looks at whether providing an information letter and a booklet helps relatives of people with Lynch syndrome decide whether to get genetic counseling or testing. About 185 adult family members will be randomly assigned to receive either a letter alone or a letter plus …

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This study looks at whether people with Lynch Syndrome—a condition that raises the risk for several cancers—follow recommended screening guidelines after genetic counseling. Researchers will track about 1,530 participants to see who gets the suggested tests and what factors help …

This study looks at how the bacteria living in your gut might affect the risk of colorectal cancer in people with Lynch syndrome or other inherited polyposis syndromes. Researchers will collect stool samples, colon tissue, and diet/lifestyle questionnaires from 77 adults during t…