LYNCH SYNDROME

This phase III trial tests whether a vaccine made from a person's own immune cells can prevent cancer in 372 adults with Lynch syndrome, a genetic condition that raises cancer risk. Participants receive either the vaccine or a placebo and are monitored for tumor development. The …

This early-phase trial tests a custom-made vaccine for people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine uses the person's own immune cells to target unique cancer markers. The goal is to see if it is safe and can train the immune system to prev…

This study tests a web-based program called Kindred that helps African American families understand their genetic cancer risk and talk about testing. About 150 people will use the tool to see if it improves knowledge and testing rates. The goal is to make genetic information more…

This study will check if a newer, cheaper DNA sequencing machine (MGI) gives the same results as the current standard (Illumina) when testing for genetic changes linked to breast, ovarian, and other cancers. Researchers will use leftover DNA samples from 248 patients who already …

This study looks at 150 people with Lynch syndrome to find out how many also have Muir-Torre syndrome, a condition that causes certain skin tumors. Researchers will check skin and other tumors for genetic changes and build a tissue bank for future research. The goal is to better …

This study compares a swallowable camera capsule to standard colonoscopy for detecting colon cancer in people with Lynch syndrome, a genetic condition that greatly raises colon cancer risk. About 78 adults aged 18-60 will try both methods to see if the capsule is as safe and effe…

This study aims to find out how common gum disease (periodontitis) is in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will compare gum health in 25 adults with Lynch syndrome to general population data. No treatment is given; the study simp…

This study looks at whether easy-to-collect samples like blood, urine, stool, and vaginal swabs can predict cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Currently, monitoring requires invasive procedures like colonoscopies. The goal is to see…

This study tests an online tool called Let's Talk to help people with Lynch syndrome encourage their relatives to get screened for cancer risk. Researchers will work with 20 participants (15 patients and 5 genetic counselors) to see if the tool is easy to use and improves knowled…