LEIOMYOSARCOMA

This study is testing if taking a drug called regorafenib for up to a year can help prevent bone cancers (sarcomas) from returning after patients finish their initial chemotherapy and surgery. It will compare patients who take the drug to those who receive standard monitoring wit…

This large Phase 3 study is testing whether adding a newer drug called lurbinectedin to the standard chemotherapy doxorubicin works better for controlling metastatic leiomyosarcoma, a rare and aggressive muscle tissue cancer. The trial will enroll 450 adults who haven't had previ…

This early-stage trial aims to find a safe and effective dose of two drugs—gemcitabine and nab-sirolimus—when used together. It is for adults with advanced leiomyosarcoma or other soft-tissue sarcomas that have specific genetic changes (TSC1 or TSC2 mutations) and have stopped re…

This study is testing an oral medication called anlotinib for people with advanced forms of soft tissue sarcoma that have spread or cannot be removed by surgery. The main goal is to see if the drug can shrink tumors or slow their growth compared to standard chemotherapy. The tria…

This study is testing whether selecting certain patients to receive proton radiation instead of standard X-ray radiation before sarcoma surgery can reduce long-term side effects while maintaining the same treatment effectiveness. For each of the 110 adult participants in Norway, …

This study is testing whether combining two drugs, ATRA and cemiplimab, can help control advanced leiomyosarcoma, a type of cancer, in patients whose disease has worsened despite standard treatments. It will enroll 16 adults to see if the combination can shrink tumors or stop the…

This study is testing whether adding a new immunotherapy drug called tislelizumab to standard chemotherapy works better for people with advanced soft tissue sarcoma. It will enroll 45 adults with specific types of sarcoma that cannot be removed by surgery or have spread. The main…

This study is testing whether an experimental cell therapy called tabelecleucel can help control diseases caused by the Epstein-Barr virus in people with weakened immune systems. The trial includes 190 participants who have developed serious conditions like lymphomas or sarcomas …

This study aims to find blood markers that can predict how well chemotherapy works for people with advanced leiomyosarcoma, a rare and aggressive cancer. Researchers will collect blood samples from 200 patients before and during their first chemotherapy treatment to look for canc…

This study aims to find better ways to predict if chemotherapy is working for patients with a type of cancer called leiomyosarcoma. Researchers will test blood samples for tiny pieces of cancer DNA and analyze detailed scans to see if these can tell doctors early on which patient…