HEMATOLOGIC MALIGNANCY

This early-stage study tests the safety of a new drug called ziftomenib when combined with standard chemotherapy for people with a specific type of acute myeloid leukemia (AML) that has come back or not responded to treatment. About 171 adults with certain genetic markers (NPM1 m…

This study is for people living with HIV who also have a blood cancer that can be treated with a bone marrow transplant. Researchers want to see if a new mix of three drugs can safely prevent graft-versus-host disease, a common complication where donor cells attack the patient's …

This study is for people who have had a stem cell transplant for blood cancer and are at high risk of serious fungal infections. The standard preventive drug may not work well enough anymore. Researchers are testing a stronger drug, posaconazole, and checking its levels in the bl…

This study looks at the long-term safety and benefits of the drug pelabresib in people with blood cancers, solid tumors, or advanced cancers. It includes up to 50 adults who were in earlier pelabresib studies and are still benefiting from the drug. Some participants who received …

This study tests a new way to do a stem cell transplant for children with a hard-to-treat type of leukemia (ALL). It uses special immune cells (CAR T cells) from a partially matched family donor to try to kill any remaining cancer cells after the transplant. The goal is to see if…

This early-phase study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in 8 adults with blood cancers or bone marrow failure who are at high risk of rejecting a stem cell transplant. The goal is to reduce DSA levels enough to allow the transplant t…

This early-phase study tests whether injecting specially grown immune cells (HTLP) after a cord blood transplant can help rebuild the immune system more quickly in adults with blood cancers. Ten participants will receive the injection and be monitored for side effects like graft-…

This early-phase study tests whether collecting a patient's own blood stem cells and giving them alongside CAR-T cell therapy is safe and doable for people with blood cancers that have come back or not responded to treatment. About 20 adults with cancers like lymphoma, leukemia, …

This study tests whether combining two oral drugs, pirtobrutinib and venetoclax, can control mantle cell lymphoma (MCL) in patients whose cancer has come back or hasn't responded to prior treatments. About 30 adults with confirmed MCL will take these pills to see how many achieve…

This study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil along with their usual GVHD prevention medicin…

This study tests two different pre-transplant conditioning plans combined with a single drug (cyclophosphamide) after transplant to prevent graft-versus-host disease (GVHD) in 82 adults with blood cancers. Participants receive a stem cell transplant from a matched donor. The goal…

This study tests a stem cell transplant for people with blood cancers like leukemia or lymphoma. It uses a milder chemotherapy and radiation plan to prepare the body for a half-matched donor's stem cells. The goal is to see if this approach helps the new cells grow safely and con…

This study looks at a new approach to safely use beta-lactam antibiotics (like penicillin) in people with blood cancers who have a reported allergy to them. The goal is to see if this approach leads to better antibiotic use and shorter hospital stays. About 3,800 participants wil…

This early-stage trial tests a new treatment for children and young adults (up to age 21) with blood cancers like leukemia or lymphoma that have returned or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recogn…

This study looks at how long to give the drug maribavir to treat a stubborn CMV infection in people who had a stem cell transplant for blood cancer. About 218 adults will get either a shorter or longer course of maribavir. The goal is to see which approach better prevents the vir…

This early-stage study tests a new way to do stem cell transplants for children and young adults with hard-to-treat blood cancers. The approach uses special immune cells from a half-matched donor to help the body accept the transplant and fight cancer, while trying to lower the r…

This early-stage study tests whether adding two drugs, decitabine and venetoclax, to a standard stem cell transplant can make the treatment safer for people with high-risk blood cancers like leukemia. About 20 adults aged 18-75 with a matching donor will receive the new drug comb…

This study tests a new type of stem cell transplant for children and adults with blood cancers like leukemia. The transplant uses a special process to remove certain immune cells, which may lower the chance of the donor cells attacking the patient's body (graft-versus-host diseas…

This early-stage trial tests whether adding abatacept to standard anti-rejection drugs can safely prevent graft-versus-host disease (GVHD) in 10 adults with blood cancers receiving a special type of stem cell transplant (omidubicel). Participants will receive the drug combination…

This study tests a new treatment called QH101 for people with blood cancers or solid tumors that have not responded to standard therapy. QH101 uses specially designed immune cells from a donor to better recognize and attack cancer cells while lasting longer in the body. The trial…

This study aims to create a blood test that can find many types of cancer at an early stage. Researchers will analyze DNA from blood samples of 6,000 people, including those with and without cancer, to train an artificial intelligence platform. The goal is to improve early detect…

This study tests if combining a special diet supplement with online brain training can improve memory and thinking in blood cancer survivors. About 80 adults who have finished treatment will either get the combined program right away or wait 12 weeks. The goal is to see if this a…

This study tests a program called Nite2Day+ that uses mindfulness and sleep tips to help blood cancer patients sleep better and manage fatigue, stress, and pain. About 60 adults with certain blood cancers will either get the program or standard care. The program includes a mobile…

This study explores whether a four-week online expressive writing workshop can improve mental wellness in young adults (ages 18-39) with blood cancer. Participants will attend the workshop and complete three surveys over 12 weeks to track changes in wellbeing and stress. The goal…

This study tests whether giving blood transfusions at home is practical and acceptable for cancer patients who need regular transfusions. About 30 adults with blood cancers or bone marrow failure will receive 1-5 blood product units at home. Researchers will track how often trans…

This study tests a program called BMT-CARE designed to improve the quality of life for people caring for a loved one undergoing a bone marrow transplant. Researchers will compare the well-being of 800 caregivers who receive the program versus those who get usual care. The goal is…

This study looks at whether offering blood transfusions at home for people with advanced blood cancers who are in hospice care can improve their quality of life, mood, and reduce hospital visits near the end of life. About 700 adults with relapsed or hard-to-treat blood cancers w…

This study tests a new program called Sentinel that helps doctors provide extra comfort and support to patients getting a stem cell transplant. The program is designed to be part of regular care. The study will check if the program is practical and if patients like it. About 40 a…

This study looks at whether a 12-week home exercise program with remote coaching can help lymphoma survivors improve their heart and lung fitness and stay active after cancer treatment. About 80 adults who finished chemotherapy for lymphoma will either exercise at home with remot…

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can improve quality of life for adults with blood cancers like lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly a…

This study tests whether using a virtual reality (VR) headset during a bone marrow biopsy can lower pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use VR or standard care. The goal is to see if VR offers a simple, drug-free way to improve the p…

This study looks at how a stem cell transplant changes a person's DNA and how that affects drug dosing. Researchers will collect blood, skin, hair, and other samples from 88 adults before and after transplant. The goal is to find the best way to test a patient's genes for safe an…

This study tests a new tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant and cellular therapy decisions. The goal is to see if the tool is practical and helpful for families. About 60 youth and their…

This study aims to find out if certain blood markers can predict how well cancer patients respond to immunotherapy. Researchers will collect blood samples from 1500 people with different types of cancer before and during treatment. Participants will be followed for up to 6 months…

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. About 60 adults who just received CAR-T cells will get heart ultrasounds before and a few days after treatment. The goal is to measure how often heart functio…

This study follows 100 children and young adults who received CAR T cell therapy to understand short- and long-term side effects like infections, slow blood cell recovery, and nerve problems. Researchers will check participants at 3, 6, 12, and 24 months after treatment. The goal…

This study looks at blood samples from 50 people with blood cancers who are getting CAR T therapy. Researchers want to see how certain immune cells change over time and if those changes are linked to the cancer coming back or not responding. The goal is to learn more, not to test…

This study looks at how the body handles venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured. The…

This study aims to understand how well the seasonal flu vaccine works in children with blood cancers like leukemia. Researchers will measure the immune response in up to 150 children at St. Jude Children's Research Hospital. The goal is to see if the vaccine triggers enough prote…

This study looks at how energy use inside cancer and immune cells changes the bone marrow and may make treatments stop working. Researchers will collect samples from 350 adults with certain blood cancers and from healthy volunteers. The goal is to find new clues that could lead t…