HEMATOLOGIC MALIGNANCY

This study tests a new way to do stem cell transplants for 20 children with blood cancers or myelodysplasia who don't have a perfect donor match. Doctors remove certain immune cells from a parent's partially matched stem cells before transplant to help the new cells grow faster a…

This study tests whether replacing a standard immune-suppressing drug with tocilizumab can prevent graft failure and graft-versus-host disease in blood cancer patients receiving a special type of bone marrow transplant. About 21 adults with high-risk blood cancers are participati…

This study tests whether a special immune test can help doctors decide how long to use an anti-CMV drug (letermovir) after a stem cell transplant. The goal is to prevent late-onset CMV infection, a common and serious complication. The trial involves 250 adults receiving their fir…

This early-phase study tests whether giving healthy donor NK cells along with two medicines (vactosertib and IL-2) is safe and helps the cells stay active in people with advanced colorectal, stomach, esophageal, or blood cancers. The NK cells are meant to attack cancer, but the b…

This study tests a mobile app (CARE) designed to support caregivers of people receiving a bone marrow or stem cell transplant for cancer. About 120 adult caregivers will use the app or receive standard support to see if it improves their quality of life and reduces stress. The go…

This study collects leftover tissue and blood samples from 1,200 adults with known or suspected cancer during their standard surgeries or biopsies. Researchers will compare cancerous and normal tissues to find differences that could lead to new cancer treatments. No extra procedu…

This study looks at how doctors and patients feel about using a new tool to choose antibiotics for people with blood cancer who have a reported penicillin allergy. The goal is to find out what might make it hard or easy to use this tool in everyday hospital care. About 80 patient…

This study tests whether two computer-based survey methods (REDCap and Touchscreen) are practical and reliable for assessing the health of older adults (65+) with cancer. About 100 participants will complete a geriatric assessment on a computer to see if it works as well as tradi…

This study follows about 150 people who previously received Caribou cell therapy for blood cancers like lymphoma or leukemia. Researchers will check for long-term side effects and overall survival for up to 15 years after treatment. No new treatment is given—this is just observat…

This study collects bone marrow samples from 70 people with blood cancer to create 3D organoids—tiny lab-grown models of the cancer. Researchers will test different chemotherapy combinations on these organoids to see which kills the most cancer cells. The goal is to learn if this…

This study tests a program called PATH-C that uses positive psychology exercises to improve well-being, quality of life, and physical activity in caregivers of stem cell transplant patients. About 80 adult caregivers will be randomly assigned to the program or usual support. The …

This study monitors people who previously received AvenCell's CAR-T cell therapy for blood cancers or prostate cancer. The goal is to check for long-term side effects, including new cancers, nerve problems, or immune disorders. About 178 participants will be followed over time to…