HEAD AND NECK NEOPLASMS

This study tests a new approach for people with certain head and neck cancers: using lower doses of radiation and chemotherapy, followed by surgery to remove any remaining cancer in the neck. The goal is to see if this gentler treatment can still control the cancer while reducing…

This study tests an experimental drug called N17350 for people with advanced solid tumors that have not responded to standard treatments. The drug is injected directly into tumor lesions every two weeks for up to 12 weeks. Researchers aim to find the safest and most effective dos…

This study tests a less intense treatment for older adults (65+) with head and neck cancer who are considered frail. Participants receive a personalized mix of chemotherapy and immunotherapy based on their tumor's markers, followed by a shorter course of radiation. The goal is to…

This early-phase study tests a new three-drug combination (zanzalintinib, pembrolizumab, and cetuximab) in adults with recurrent or metastatic head and neck cancer that cannot be cured by local treatments. The main goal is to find the safest dose and check for early signs of tumo…

This early-stage study tests a new drug called AZD9592, alone or with other cancer treatments, in people with advanced solid tumors (lung, head & neck, or colorectal cancer that has spread). The main goals are to check safety, find the right dose, and see if it shrinks tumors. Ab…

This study looks at whether adjusting the dose of chemotherapy drugs (5-FU or capecitabine) based on a person's DPYD gene test can reduce severe side effects. About 100 adults with certain cancers (like colorectal, breast, or head/neck) will take part. The goal is to see if perso…

This program gives children and young adults with central nervous system or head and neck tumors access to a special PET scan that uses a tracer called methionine. The scan helps doctors see the tumor more clearly and make better treatment decisions. Anyone under care at St. Jude…

This study tests a light therapy called photobiomodulation to see if it can improve dry mouth, swallowing, and overall quality of life in 60 head and neck cancer survivors who have finished radiation. Participants will use a mobile health tool to track their symptoms. The goal is…

This study looks at whether starting a physical activity program before and continuing it during radiotherapy can help head and neck cancer patients maintain their physical function and quality of life. About 80 participants will be randomly assigned to either an exercise group o…

This study tests a new way to give radiation for head and neck cancer that tries to protect the parts of the throat used for swallowing. About 136 people with certain types of head and neck cancer will be randomly assigned to get either this new radiation or standard radiation. T…

This study looks at whether giving fluoride varnish during regular cancer follow-up visits can help improve oral health for head and neck cancer patients who have had radiation and lack easy access to dental care. About 120 uninsured or underinsured adults will take part. Researc…

This study tests whether a heavy lifting strength training program can help head and neck cancer survivors regain muscle strength, reduce fatigue, and improve quality of life. About 60 adults who finished cancer treatment at least one year ago will be randomly assigned to either …

This study tests if ozone gas therapy, alone or with special toothpaste and mouthwash, can reduce painful mouth sores caused by radiation or chemotherapy. About 50 adults with head and neck cancer who have mouth sores will be randomly assigned to ozone therapy or ozone plus a hom…

This study is testing whether special PET and MRI scans can help doctors personalize radiation therapy for people with head and neck cancer. About 390 participants will get scans before and during treatment to see if the images can predict survival and reduce side effects. The go…

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover tissue from medical procedures and collect additional samples like blood, saliva, and c…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study looks at the genetic makeup of head and neck tumors from 1000 people to find clues about which treatments work best and why some tumors come back. Researchers will analyze tumor tissue from biopsies or surgeries. The goal is to better understand how genes affect progno…

This study aims to create a large collection of biological samples to help scientists better understand disorders affecting hearing, balance, voice, and swallowing. Researchers will collect leftover tissue from medical procedures, plus blood, saliva, and cheek swabs from up to 1,…