HEAD AND NECK NEOPLASMS

This large, completed Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to standard chemoradiation treatment works better than chemoradiation alone for people with locally advanced head and neck cancer. The study enrolled 804 patients to see if the combinat…

This study compared two standard treatment approaches for advanced head and neck cancer that had spread to lymph nodes. It tested whether performing neck surgery before combined chemotherapy and radiation could reduce severe treatment side effects and improve quality of life, wit…

This study tested whether combining two existing cancer drugs, pembrolizumab and cetuximab, could help control advanced head and neck cancer that had returned or spread. It involved 78 patients at four US cancer centers, grouped based on their prior treatments. The main goal was …

This study tested whether a daily pill called afatinib works better than a standard intravenous chemotherapy (methotrexate) for patients with advanced head and neck cancer that has continued to grow after initial platinum-based treatment. It involved 340 patients and aimed to see…

This study tested whether using lower radiation doses to healthy neck lymph nodes could reduce long-term side effects while still preventing cancer recurrence. It involved 300 adults with head and neck cancer who were scheduled for curative radiation treatment. Researchers compar…

This study tested whether a short exercise program before starting cancer treatment helps patients with head and neck cancer. Forty-seven adults scheduled for combined chemotherapy and radiation were randomly assigned to either do exercise training or receive usual care for at le…

This study looked back at whether ozone therapy could help cancer patients with severe mouth sores caused by radiation and chemotherapy. It involved 38 patients who received professional ozone treatments and used special ozonated oil at home. Researchers measured if this approach…

This study tested whether providing active nutritional support could help head and neck cancer patients receiving radiotherapy. It aimed to see if better nutrition could reduce the painful mouth sores (mucositis) that are a common and debilitating side effect of treatment. The go…

This study tested two non-drug treatments to help cancer patients with painful mouth sores, a common and debilitating side effect of chemotherapy and radiation. Forty adults with head, neck, or blood cancers were randomly assigned to receive either laser light therapy or ozone ga…

This study tested whether real acupuncture is better than fake acupuncture at helping head and neck cancer patients feel less tired and maintain better blood cell counts during combined chemotherapy and radiation. 34 adult patients were randomly assigned to receive either real or…

This study tested a special 3D MRI technique to create detailed maps of nerves in the face and neck of young children. The goal was to see if these maps could help surgeons better plan operations for tumors or birth defects in this delicate area. Seven children aged 1 to 5 who we…