New pill tested against standard IV drug for Tough-to-Treat head and neck cancer

NCT ID NCT01856478

Summary

This study tested whether a daily pill called afatinib works better than a standard intravenous chemotherapy (methotrexate) for patients with advanced head and neck cancer that has continued to grow after initial platinum-based treatment. It involved 340 patients and aimed to see which treatment could better control the cancer's growth, help patients live longer, and improve their quality of life, particularly regarding pain and swallowing.

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Contacts and locations

Locations

  • Acharya Tulsi Regional Cancer Treatment & Research Institute

    Bikaner, 334001, India

  • Alexandria Clinical Research Center

    Alexandria, 21131, Egypt

  • Asan Medical Center

    Seoul, 138-736, South Korea

  • B. P .Poddar Hospital & Medical Research Ltd.

    Kolkata, West Bengal, 700053, India

  • Beijing Chao-Yang Hospital

    Beijing, 100020, China

  • Cancer Hospital of Chinese Academy of Medical Science

    Beijing, 100021, China

  • Fudan University Shanghai Cancer Center

    Shanghai, 200032, China

  • Geetanjali Medical College and Hospital

    Jaipur, 313002, India

  • Government Medical College & Hospital

    Nagpur, 440009, India

  • Harbin Medical University Cancer Hospital

    Harbin, 150081, China

  • J K Cancer Institute

    Kanpur, 208005, India

  • Keelung Chang Gung Memorial Lover's Lake Branch

    Keelung, 204, Taiwan

  • King George Medical University

    Lucknow, 226003, India

  • M N J Institute of Oncology and Regional Cancer Centre

    Hyderabad, 500004, India

  • Maharaj Nakom Chiangmai Hospital

    Chiang Mai, 50200, Thailand

  • Mansoura University Faculty of Medicine

    Dakahlia, 35516, Egypt

  • Naresuan University Hospital

    Phitsanulok, 65000, Thailand

  • National Cancer Center

    Goyang, 10408, South Korea

  • National Cancer Institute, Cairo University

    Cairo, 11796, Egypt

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • Navy General Hospital

    Beijing, 100037, China

  • Noble Hospital Pvt Ltd

    Pune, 411013, India

  • Pamela Youde Nethersole Eastern Hospital

    Hong Kong, 999077, Hong Kong

  • Peking Union Medical College Hospital

    Beijing, 100730, China

  • Perpetual Succour Hospital (Cebu)

    Cebu City, 6000, Philippines

  • Prince of Wales Hospital

    Shatin, 999077, Hong Kong

  • Pristine Hospital

    Bengaluru, 560086, India

  • Queen Mary Hospital

    Hong Kong, 999077, Hong Kong

  • Rajiv Gandhi Government General Hospital

    Chennai, 600003, India

  • Renji Hospital Shanghai Jiaotong Univesrity School of Medicine

    Shanghai, 200001, China

  • Ruby Hall Clinic

    Pune, 411001, India

  • Samsung Medical Center

    Seoul, 135-710, South Korea

  • Severance Hospital

    Seoul, 120-752, South Korea

  • Shanghai Changzheng Hospital

    Shanghai, 200003, China

  • Shanghai Ninth People's Hospital

    Shanghai, 200011, China

  • Shanghai Ninth People's Hospital

    Shanghai, 200125, China

  • Shatabdi Hospital, Nashik

    Nashik, 422002, India

  • Sichuan Cancer Hospital

    Chengdu, 610041, China

  • Songklanagarind Hospital

    Songkhla, 90110, Thailand

  • Srinagarind Hospital

    Muang, 40002, Thailand

  • St. Luke's Medical Center

    Quezon City, 1102, Philippines

  • Sujan Surgical Cancer Hospital

    Amravati, 444606, India

  • Sun Yat-Sen University Cancer Center

    Guangzhou, 510060, China

  • Taichung Veterans General Hospital

    Taichung, 407, Taiwan

  • The Catholic University of Korea, Seoul St.Mary's Hospital

    Seoul, 137-701, South Korea

  • The First Affiliated Hospital Of Bengbu Medical College

    Bengbu, 233004, China

  • The First Hospital of Jilin University

    Changchun, 130021, China

  • Tongji Hospital, Tongji University

    Wuhan, 430030, China

  • Tri-Service General Hospital

    Taipei, 11490, Taiwan

  • West China Hospital

    Chengdu, 610042, China

  • Wuhan Union Hospital

    Wuhan, 430022, China

  • Zhejiang Cancer Hospital

    Hangzhou, 310022, China

  • the 81th Hospital of PLA

    Nanjing, 210002, China

Conditions

Explore the condition pages connected to this study.