HEAD AND NECK NEOPLASMS

This study was designed for people with advanced head and neck cancer that had spread or come back. It aimed to test a combination of two drugs: decitabine (a chemotherapy drug) and nivolumab (an immunotherapy drug). The goal was to see if the combination was safe and could help …

This early-stage trial tests an experimental drug called AZD9592, alone or with other cancer drugs, in about 167 adults with advanced solid tumors (including lung, head & neck, and colorectal cancers). The main goals are to check safety, find the right dose, and see if the drug s…

This phase 2 trial tests an experimental drug called disitamab vedotin in people with advanced head and neck, lung, endometrial, or ovarian cancers that have a protein called HER2. The drug is designed to stick to cancer cells and kill them. Researchers want to see if it shrinks …

This phase 2 study tests the drug entrectinib in over 500 people with advanced solid tumors that have specific gene changes (NTRK, ROS1, or ALK fusions). The goal is to see if the drug can shrink tumors and control the disease. Participants have various cancer types, including lu…

This phase 3 trial tests whether adding the immunotherapy drug pembrolizumab before and after surgery can help people with advanced head and neck cancer stay cancer-free longer. About 714 participants receive either pembrolizumab plus standard radiation (with or without chemo) or…

This early-phase study tests whether a new treatment called KSQ-001EX is safe for people with advanced solid tumors like melanoma, lung cancer, or head and neck cancer. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are genetically modified …

This pilot study looks at whether giving fluoride varnish during regular cancer checkups can help protect the teeth of head and neck cancer patients who have had radiation and lack easy access to a dentist. About 43 uninsured or underinsured adults will receive 4-5 fluoride treat…

This early-phase study tests whether a mouthwash made from copaiba, a natural oil from the Amazon, can safely help prevent and treat painful mouth sores caused by radiation therapy in 20 adults with head and neck cancer. Researchers will find the highest safe dose and measure pai…

This study compares two treatments for early-stage throat cancer: robotic surgery (TORS) or radiation therapy (IMRT). It looks at which one leads to better swallowing function and overall quality of life. About 138 adults with HPV-related throat cancer are taking part. The goal i…

This study follows 100 head and neck or lung cancer patients who are current or former smokers and receive radiation therapy. Researchers track who stays smoke-free at 1, 6, and 12 months after treatment ends, and what factors help or hinder abstinence. The goal is to learn how t…

This study aimed to see if a personalized online education program could help people having major head or neck surgery feel more prepared and satisfied, and reduce trips to the hospital. The study was withdrawn before any participants were enrolled, so no results are available.