HEAD AND NECK NEOPLASMS

This study tests whether adding the immunotherapy drug pembrolizumab before and after surgery can help people with advanced head and neck cancer live longer without their cancer coming back. About 714 participants with stage III or IVA disease will receive either pembrolizumab pl…

This study tests an experimental drug called disitamab vedotin in 120 adults with advanced head/neck, lung, endometrial, or ovarian cancers that have the HER2 marker. The drug is designed to stick to cancer cells and kill them. Participants receive the drug every two weeks to see…

This study tests a drug called entrectinib in people with advanced solid tumors that have certain gene changes (NTRK, ROS1, or ALK). The drug aims to shrink or control the cancer by blocking these faulty genes. About 534 adults with various cancers, including lung, breast, and br…

This study tests whether a blood test that tracks tumor DNA can help doctors decide when to add short bursts of chemotherapy to standard immunotherapy for people with head and neck cancer that has returned or spread. About 30 adults will receive the immunotherapy drug pembrolizum…

This early-phase study tests a new treatment called KSQ-001EX for people with advanced solid tumors (melanoma, lung, or head/neck cancers) that have not responded to standard therapy. The treatment involves taking a patient's own tumor-fighting immune cells, modifying them in a l…

This study compares two treatments for early-stage throat cancer: robotic surgery or radiation therapy. It looks at which one leads to better quality of life, especially swallowing. About 138 people took part. The goal is to help patients and doctors choose the best option.

This early-stage study tests a mouthwash made from copaiba, a natural oil from the Amazon, to see if it can safely prevent or treat painful mouth sores caused by radiation therapy for oral cancer. About 36 adult patients will try different doses of the mouthwash. The main goal is…

This study aimed to see if a personalized online education program could help patients and their caregivers feel more prepared before and after major head and neck surgery, and reduce trips back to the hospital. The program was designed for adults undergoing free flap surgery or …

This study looks at what helps people with head and neck or lung cancer stay away from cigarettes after they finish radiation treatment. Researchers will follow 100 patients for a year, checking in at 1, 6, and 12 months after treatment ends. The goal is to understand why some pe…