EWING SARCOMA

This study is testing a personalized peptide vaccine for children and young adults (up to age 30) with metastatic fusion-driven sarcomas (Ewing sarcoma, rhabdomyosarcoma, synovial sarcoma) who have completed standard treatment. The vaccine is custom-made for each patient based on…

This study tests a drug called lurbinectedin in people aged 10 and older whose solid tumors (like Ewing sarcoma) have returned after standard treatment. The goal is to see if the drug is safe and can shrink tumors or delay their growth. Participants must have a specific genetic c…

This study tests a new treatment for children and young adults up to age 21 with sarcomas that have come back or not responded to standard therapy. It combines a special type of immune cell (B7-H3-CAR T cells) with targeted radiation to see if it is safe and can shrink tumors. Ab…

This early-stage study is testing whether combining two drugs, cabozantinib and high-dose ifosfamide, is safe and effective for people with sarcomas (a type of cancer) that have returned or not responded to standard treatment. About 30 children and adults will take part. The main…

This early-phase study tests a personalized cell therapy for children and young adults up to age 21 with solid tumors that have returned or not responded to standard care. The therapy uses the patient's own immune T cells, which are genetically modified to recognize and attack a …

This study tests whether adding specially trained immune cells (NK cells) to standard chemotherapy can help children and young adults with sarcoma that has returned or not responded to prior treatments. About 50 participants aged 2 to 40 with certain types of sarcoma will receive…

This study looks at whether the drug regorafenib can help prevent bone sarcomas from coming back after initial treatment. About 168 people with different types of bone sarcoma will be randomly assigned to take regorafenib for up to 12 months or to receive standard monitoring. The…

This early-phase trial tests an experimental oral drug called ST-01156 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The drug works by breaking down a protein inside cancer cells. The main goals are to find a safe dose and check for side e…

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma or sarcoma) have come back or not responded to treatment. The goal is to find a safe dose and see if the c…

This study tests whether adding eflornithine (DFMO) to standard chemotherapy can help teens and young adults with Ewing sarcoma or osteosarcoma live longer without their cancer coming back. About 406 participants will join one of five groups based on their cancer type and stage. …

This study tests a new way of giving radiation therapy for Ewing sarcoma, a rare bone and soft tissue cancer. The radiation dose is tailored to each patient's tumor size and biology, with higher doses given over a shorter time. The goal is to reduce the chance of the cancer retur…

This early-phase trial is testing an experimental drug called xaluritamig in about 50 people (adults, teens, and children) whose Ewing sarcoma has returned or stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers…

This early-stage trial tests a new drug called INBRX-109 in people with advanced solid tumors, including Ewing sarcoma and colorectal cancer. The drug is designed to attach to a protein on cancer cells and trigger their death. The main goals are to check safety and see if the dru…

This early-stage trial tests a new treatment for children whose solid tumors (rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, or Wilms tumor) have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in the lab to b…

This study tests two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas (cancers of the soft tissue or bone) that have spread or cannot be removed by surgery. The goal is to see if the combination can stop the cancer from growing for at least 6 months. About …

This study tests an experimental oral drug called AMXT 1501 combined with eflornithine (DFMO) in children and young adults up to age 21 with neuroblastoma, brain tumors, or sarcomas. The goal is to find the best dose, check safety, and see if the combination helps keep the cancer…

This early-stage study tests whether giving HER2-targeting CAR T cells along with an immune checkpoint inhibitor (pembrolizumab or nivolumab) is safe for people with advanced sarcoma. About 25 participants will receive chemotherapy to prepare their bodies, then the CAR T cells, f…

This early-phase study tests a new drug called DXC008 in people with prostate cancer or other solid tumors (like Ewing sarcoma) who have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. Abou…

This early-phase study tests a four-drug combination (vorinostat plus three chemotherapy drugs) in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goal is to find a safe dose and und…

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid. The goal is to help the donor cells attack the tumor more effectively while reducing side effects. It is for children and young…

This study is for children, teens, and young adults up to age 39 with sarcoma that has spread to a few other places in the body. Researchers want to see if giving extra radiation to those spread spots, along with usual treatment, can help them live longer without the cancer growi…

This study tests a drug called lurbinectedin in children and young adults (ages 2 to 30) with Ewing sarcoma that has returned or not responded to prior treatments. The first part finds the safest dose, and the second part checks if the drug shrinks tumors. About 60 participants w…

This early-stage study tests a new type of stem cell transplant for children whose blood cancers or solid tumors have returned or are hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells and give a drug called zoledronate after tr…

This study tests an experimental drug called zilovertamab vedotin in children and young adults (ages 1 to <18) whose blood cancers (like B-cell acute lymphoblastic leukemia, diffuse large B-cell lymphoma, or Burkitt lymphoma) or solid tumors (neuroblastoma or Ewing sarcoma) have …

This study looks at how to safely preserve fertility in children with neuroblastoma or Ewing sarcoma. When ovarian or testicular tissue is frozen before cancer treatment, there is a risk that cancer cells could be put back into the body later. Researchers will compare two lab met…

This early-stage study tests whether people with advanced solid tumors can safely follow a diet low in methionine, an amino acid found in many proteins. Researchers will measure how well participants stick to the diet, check for side effects, and track changes in blood methionine…

This study looks at how closely bone cancer patients follow a personalized home exercise program in the first six months after lower leg surgery. Researchers will track daily exercise logs and explore what factors help or hinder adherence. The goal is to improve rehabilitation su…