ADVANCED MELANOMA
Clinical trials for ADVANCED MELANOMA explained in plain language.
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New cancer drug injected directly into tumors shows promise in early trial
Disease control CompletedThis early-stage study tested a new drug, CyPep-1, which is injected directly into tumors. It was combined with the immunotherapy drug pembrolizumab to see if it could help control advanced head and neck cancer, melanoma, or triple-negative breast cancer. The main goals were to c…
Matched conditions: ADVANCED MELANOMA
Phase: PHASE1, PHASE2 • Sponsor: Cytovation AS • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Personalized vaccine shows promise against deadly skin cancer
Disease control CompletedThis study tested whether adding a personalized cancer vaccine (autogene cevumeran) to standard immunotherapy (pembrolizumab) works better than immunotherapy alone for people with advanced melanoma that hasn't been treated before. The trial involved 131 patients with advanced ski…
Matched conditions: ADVANCED MELANOMA
Phase: PHASE2 • Sponsor: Genentech, Inc. • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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First human test of new melanoma drug cocktail
Disease control CompletedThis early-stage study tested the safety of a new three-drug combination (LBL-007, toripalimab, and axitinib) for people with advanced melanoma that cannot be removed by surgery. The main goal was to find the highest safe dose and see what side effects occurred. Researchers also …
Matched conditions: ADVANCED MELANOMA
Phase: PHASE1 • Sponsor: Nanjing Leads Biolabs Co.,Ltd • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New drug duo tested for Tough-to-Treat skin cancer
Disease control CompletedThis early-stage study tested the safety and initial effectiveness of combining two existing cancer drugs, trametinib and ceritinib, in patients with advanced melanoma that could not be surgically removed. It involved 27 patients whose cancer had worsened despite previous standar…
Matched conditions: ADVANCED MELANOMA
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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Direct tumor shots tested to revive immune attack on stubborn melanoma
Disease control CompletedThis study tested a new approach for patients with advanced melanoma that had stopped responding to standard immunotherapy. Doctors injected an experimental drug called LTX-315 directly into accessible tumors, while also giving the immunotherapy drug pembrolizumab. The goal was t…
Matched conditions: ADVANCED MELANOMA
Phase: PHASE2 • Sponsor: Lytix Biopharma AS • Aim: Disease control
Last updated Mar 18, 2026 18:25 UTC
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Blood test could predict which melanoma patients benefit from immunotherapy
Knowledge-focused CompletedThis research study aimed to understand how immune cells in the blood might predict whether melanoma patients respond to pembrolizumab immunotherapy. Researchers followed 25 patients with advanced melanoma who were starting standard pembrolizumab treatment. They analyzed blood sa…
Matched conditions: ADVANCED MELANOMA
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Scientists bank cancer samples to crack treatment resistance code
Knowledge-focused CompletedThis study collected blood and tumor tissue samples from 64 patients with advanced cancers to build a research library. The goal was to understand why cancers stop responding to treatments and to find better ways to match future patients with effective therapies. Samples were tak…
Matched conditions: ADVANCED MELANOMA
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Mar 13, 2026 15:06 UTC