New combo therapy shows promise in early cancer trial

NCT ID NCT05383170

First seen Jan 08, 2026 · Last updated May 01, 2026 · Updated 16 times

Summary

This early-phase study tested a new drug called CyPep-1, injected directly into tumors, combined with the immunotherapy pembrolizumab. It included 6 people with advanced head and neck, melanoma, or triple-negative breast cancers. The main goals were to check safety and see if the combo could shrink both injected and non-injected tumors.

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Contacts and locations

Locations

  • AP-HM - Hôpital de la Timone

    Marseille, France

  • Azienda Ospedaliero Universitaria Senese

    Siena, Italy

  • CHRU de Besançon

    Besançon, France

  • CHU Lille

    Lille, France

  • Centre Leon Berard

    Lyon, France

  • City Of Hope

    Duarte, California, 91010, United States

  • Clinica Universidad de Navarra Madrid

    Madrid, Spain

  • Clinica Universidad de Navarra Pamplona

    Pamplona, Spain

  • EMC

    Rotterdam, Netherlands

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Hospital Universitario 12 de Octubre

    Madrid, Spain

  • Hospital Universitario HM Sanchinarro

    Madrid, Spain

  • Hospital Universitario Virgen Macarena

    Seville, Spain

  • Houston Methodist

    Houston, Texas, 77030, United States

  • Hôpital Saint Louis - AP-HP

    Paris, France

  • Institut Bergonie

    Bordeaux, France

  • Institut Paoli Calmettes

    Marseille, France

  • Institute Gustave Roussy

    Villejuif, France

  • Istituto Europeo di Oncologia

    Milan, Italy

  • Maastricht UMC

    Maastricht, Netherlands

  • NKI/AvL

    Amsterdam, Netherlands

  • Texas Oncology - Baylor Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213-2582, United States

  • Vall d'Hebron (VHIO)

    Barcelona, Spain

Conditions

Explore the condition pages connected to this study.