Type 1 diabetes mellitus 1

This study tests a family-based behavioral program for youth aged 6-17 with type 1 diabetes who are overweight or obese, along with an overweight parent. The program focuses on healthy meal planning, food literacy, and family habits to improve weight and diabetes control. Twenty …

This study tested an updated version of the Control-IQ system, which automatically adjusts insulin delivery for people with type 1 diabetes. Sixty-six adults and adolescents used the new software along with a continuous glucose monitor for several weeks. The main goal was to see …

This study tested whether verapamil, a drug usually used for high blood pressure, can help preserve insulin-making cells in adults newly diagnosed with type 1 diabetes. 136 participants received either verapamil or a placebo for 12 months. The main goal was to see if verapamil co…

This study tested a program to help teens and young adults (ages 16-25) with type 1 diabetes better manage their blood sugar. The program focused on supporting their independence and self-care. 113 participants took part to see if this approach could improve their long-term healt…

This study tested a new insulin delivery system called Tandem Freedom in 10 adults with type 1 diabetes. Participants used their usual system at home for a week, then switched to the new system in a supervised hotel setting. The goal was to check safety and how well it controls b…

This study tested whether the Omnipod 5, a tubeless automated insulin pump, works better than multiple daily insulin injections for managing type 1 diabetes. 189 children and adults participated. The main goal was to see if the pump improved blood sugar control (HbA1c) over 13 we…

This study looked at how safe and effective Fiasp, a faster-acting mealtime insulin, is for people with type 1 or type 2 diabetes in everyday life. 42 adults used Fiasp as prescribed by their doctor for about 6 months. Researchers tracked side effects and blood sugar control to s…

This early-phase study tested a new medicine called NNC0363-1063 in 117 healthy volunteers and people with type 1 diabetes. The goal was to check safety, how the body processes the drug, and its effect on blood sugar. The study had three parts, including single and multiple doses…

This study followed 30 adults with type 1 diabetes who used the Smartguard system, a partially automated insulin pump that can pause insulin delivery when it predicts a low blood sugar. The goal was to see how well the system works in everyday life, focusing on time spent in the …

This early study tested a new approach called Stem Cell Educator therapy in 13 adults with type 1 diabetes. The treatment involves taking a patient's own blood cells, processing them with stem cells, and returning them to the body. The main goal was to see if it is safe and feasi…

This phase 2 trial tested whether infusions of PROCHYMAL, a stem cell product, could safely help people recently diagnosed with type 1 diabetes. The study enrolled 63 participants aged 12–35 who had been diagnosed within the past 20 weeks. Researchers measured how well the pancre…

This study looked at whether a special dietary supplement could help heal foot ulcers in people with diabetes and prevent the need for amputation. 35 adults with diabetes and foot ulcers were observed for 6 weeks while using the supplement at home. The main goals were to see how …

This study tested whether real-time remote blood sugar monitoring and secure texting could help teens (ages 13-18) with poorly controlled type 1 diabetes improve their blood sugar levels. Twenty teens wore a continuous glucose monitor that shared their readings with the study tea…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study tested a fully automated system that delivers both insulin and glucagon to manage blood sugar in adults with type 1 diabetes. Over 12 months, 243 participants used either the dual-hormone device or their usual care. The goal was to see if the system helps keep blood su…

This study looked at whether using a smart insulin pen (NovoPen 6) with two insulins (Tresiba and Fiasp) helps people with type 1 diabetes achieve better blood sugar levels. About 411 adults took part for 9-11 months, using their own continuous glucose monitor and a mobile app to…

This study tested whether combining two safe immune therapies—abatacept injections and nasal insulin—can help preserve the pancreas's ability to make insulin in people recently diagnosed with type 1 diabetes. The goal is to make blood sugar control easier and reduce the need for …

This study looked at how aerobic and resistance exercise impact blood sugar levels after eating in children and teens (ages 10-18) with type 1 diabetes. Forty-nine participants did different types of exercise, and their blood sugar was tracked for six hours after meals. The goal …

This study tested a smart system that combines a Bluetooth-enabled insulin pen with a continuous glucose monitor to help people with type 1 diabetes manage their blood sugar. 179 participants used either the smart system or standard insulin injections and glucose monitoring for 6…

This study tested a new medicine called dasiglucagon against the standard glucagon for treating severe low blood sugar in Asian adults and Japanese teens with type 1 diabetes. About 38 participants received both drugs in random order to see if dasiglucagon raises blood sugar just…

This study tested a new fast-acting insulin (faster aspart) against a standard insulin (NovoRapid) in 331 adults with type 1 or type 2 diabetes. Both were taken with a long-acting insulin (insulin degludec) for 16 weeks. The goal was to see if the new insulin works better at cont…

This study compares a new once-weekly insulin (icodec) to a standard daily insulin (degludec) in 582 adults with type 1 diabetes. Participants receive either weekly or daily injections, plus mealtime insulin, for about a year. The goal is to see if the weekly option controls bloo…

This study looked at how quickly a fast-acting insulin (faster aspart) enters the blood in 23 Chinese adults with type 1 or type 2 diabetes. Participants received one injection of faster aspart and one of the standard insulin NovoRapid, in random order. Blood samples were taken o…

This small study tested a new insulin delivery system called Tandem Freedom in 10 adults with type 1 diabetes. Participants first used their usual system at home for a week, then switched to Tandem Freedom in a supervised hotel setting. The main goals were to check for severe low…

This study looked at 76 children with type 1 diabetes to see if a different way of calculating insulin doses before meals could improve blood sugar control. The children used their usual rapid-acting insulin (glulisine, aspart, or lispro) via a pump. The goal was to find which me…

This early-phase trial tested the safety of a new drug called R-5280, a modified starch, in 9 children aged 11-17 who were recently diagnosed with type 1 diabetes. The study compared R-5280 to a placebo (food-grade starch) and monitored side effects and blood sugar levels over 12…

This study tested a continuous glucose monitor (CGM)-based advisory system to help adults with type 1 diabetes better manage their blood sugar. The system gives personalized advice based on glucose readings and the person's behavior and mindset. The goal was to improve glucose co…

This study tested whether using wireless continuous glucose monitors (CGM) in the hospital can help manage blood sugar levels for people with type 1 or high-risk type 2 diabetes. 157 patients wore the monitors, which sent real-time glucose readings to a care team that could adjus…

This pilot study tested whether high doses of omega-3 fatty acids (fish oil) and vitamin D are safe and can help preserve insulin production in people with type 1 diabetes. The trial included 27 participants, both children and adults, who had diabetes for up to 10 years. Research…

This completed Phase 4 trial enrolled 400 youth aged 7-25 with type 1 diabetes in low-resource settings. It compared insulin glargine (a long-acting analogue) to standard human insulin (NPH or premixed) to see if glargine reduces serious hypoglycemia or improves time in blood sug…

This completed Phase 1 study tested a new fast-acting insulin called NNC0471-0119 in 43 adults with type 1 diabetes who use an insulin pump. The goal was to see how quickly the insulin enters the bloodstream, how long it works, and how safe it is compared to a standard insulin (i…

This study tested whether personalized text messages could help young adults with type 1 diabetes feel more confident managing their condition as they moved from pediatric to adult care. 234 participants received either usual care or usual care plus a text messaging program. The …

This study tested how easy and convenient the DuraTouch® device is for injecting insulin. 128 people with type 1 or type 2 diabetes used the device for 12 weeks and rated their satisfaction. The goal was to see if the device improves the daily injection experience.

This study tested whether an online mindfulness program could help adults with type 1 or type 2 diabetes lower their blood sugar. Over 300 participants with high stress and poor glucose control were randomly assigned to either an 8-week Mindfulness-Based Stress Reduction course o…

This study looked at 347 children and teens with type 1 diabetes who use the Medtronic MiniMed 780G insulin pump. Researchers tracked how much carbohydrate they ate each day and measured their blood sugar control over time. The goal was to understand the link between daily carb i…

This study looked at how a new insulin (NNC0363-1063) interacts with a non-glucose carbohydrate (a type of sweetener) in 36 adults with type 1 diabetes. Participants received fixed doses of the insulin and different amounts of the carbohydrate in random order over 4 tests. The go…

This study tested whether a special heart ultrasound (speckle tracking strain echocardiography) can detect early heart muscle changes in 61 adults with type 1 diabetes, before symptoms appear. Researchers looked for links between these changes and small blood vessel damage (micro…

This completed study looked at 238 people who received a pancreas and kidney transplant for type 1 diabetes. The goal was to understand why diabetes sometimes returns even after a new pancreas is working. Researchers checked for immune system markers, like antibodies and T cells,…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This completed study tested a new biosensor designed to measure blood glucose every 10 minutes in people with type 1 diabetes who use an insulin pump. The sensor uses microdialysis to sample interstitial fluid and was compared to standard continuous glucose monitors (CGM) during …

This study tested a smartphone-based tool called PEPPER that gives personalized insulin dose advice to people with type 1 diabetes. The tool uses artificial intelligence to learn from each person's past data and includes safety features like low-glucose alarms. Eight adults used …

This study followed 87 active adults with type 1 diabetes who use automated insulin pumps and exercise at least twice a week. Researchers tracked their blood sugar levels before, during, and after exercise to see how well the pumps handle physical activity. The goal was to learn …

This study looked at how different types of exercise—short bursts of intense cycling versus steady moderate cycling—affect blood sugar levels in adults with type 1 diabetes. It also compared exercising after a meal versus on an empty stomach. Twenty-one physically active adults c…

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study looked at how often sleep apnea occurs in adults with type 1 diabetes. Researchers monitored 53 participants overnight using standard sleep tests and continuous glucose monitors. The goal was to measure the link between sleep-disordered breathing and blood sugar contro…

This study looked at whether eating fewer carbohydrates could help people with type 1 diabetes become more sensitive to insulin and improve blood vessel health. Fourteen adults on insulin pumps tried both a low-carb diet and a standard diet for one week each. The results showed n…

This study tested whether a Diabetes Navigator—a personal guide—helps people with type 1 diabetes use advanced devices like continuous glucose monitors and insulin pumps more effectively. 148 participants were randomly assigned to get navigator support or standard care. The main …

This study looks at 55 adults with diabetes who are either allergic to insulin or not, to better understand and diagnose insulin allergy. Researchers will test a step-by-step diagnostic approach and study the immune system's role. The goal is to make it easier to identify the exa…