Toxic encephalopathy

This study tested whether the drug siltuximab can lessen the severity of cytokine release syndrome (CRS) and neurological side effects (ICANS) that often occur after CAR-T cell therapy for blood cancers like lymphoma and leukemia. Twenty-four participants received siltuximab alon…

This completed Phase 3 trial tested whether fecal microbiota transplantation (FMT) could help people with liver cirrhosis. Nineteen patients received FMT via colonoscopy. Researchers measured liver stiffness and signs of brain confusion (hepatic encephalopathy) one month later. T…

This study tested whether nifuroxazide, a drug used for gut infections, can help treat hepatic encephalopathy—a condition where liver disease causes confusion and brain fog. Researchers gave the drug to 80 hospitalized patients with moderate to severe symptoms. The goal was to se…

This study tested whether the antibiotic rifaximin could prevent a serious brain condition called hepatic encephalopathy in people with cirrhosis who undergo a TIPS procedure. The TIPS procedure helps reduce pressure in the liver but often leads to confusion and other brain issue…

This study tested whether tadalafil, a drug often used for erectile dysfunction, can prevent nerve damage caused by docetaxel chemotherapy in men with metastatic prostate cancer. 90 participants were randomly assigned to receive either tadalafil plus standard care or standard car…

This study tested whether Phycocare, a supplement made from spirulina, can reduce nerve damage caused by the chemotherapy drug oxaliplatin in people with metastatic gastrointestinal cancers. 73 participants took either Phycocare or a placebo daily for 9 months. The goal was to se…

This study tested a sleep medication called lemborexant in 82 adults with liver cirrhosis who had trouble sleeping. The drug works by blocking wakefulness signals in the brain. Researchers measured sleep quality and checked for side effects on the liver. The goal was to see if le…

This study compared two exercise programs—thoracolumbar stabilization exercises and spinal decompression exercises—in 26 adults with Maigne's syndrome, a condition causing pain at the junction of the lower back and upper buttock. Participants did their assigned exercises three ti…

This study tested whether neurotropin, a drug that may protect nerves, can reduce the nerve damage caused by oxaliplatin chemotherapy in people with stage II or III colorectal cancer. The trial included 333 participants who had surgery and were about to start chemotherapy. Resear…

This phase 2 trial tested whether adding the drug anakinra (Kineret) to standard CAR-T cell therapy could prevent nerve toxicity in 15 people with relapsed or refractory non-Hodgkin lymphoma. Participants received anakinra injections for a week alongside their CAR-T infusion. The…

This study tested whether mangafodipir, an MRI contrast agent with antioxidant properties, could reduce nerve damage caused by oxaliplatin chemotherapy. Researchers enrolled 23 cancer patients who already had moderate nerve problems from oxaliplatin but needed to continue treatme…

This study tested whether a program of therapeutic exercise and relaxation techniques (called ATENTO) could prevent nerve damage (neurotoxicity) in women newly diagnosed with breast cancer. 42 women were split into two groups: one started the program before cancer treatment, the …

This study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …

This study followed 400 intensive care patients receiving beta-lactam antibiotics to see how often these drugs cause brain-related side effects like confusion or agitation. Researchers measured antibiotic levels in the blood and checked patients' neurological status several times…

This study looked at whether speech features—like how people sound and what they say—can help detect or predict confusion caused by liver disease (hepatic encephalopathy). Researchers recorded speech tasks from 251 participants with cirrhosis and tracked their thinking skills and…