Toxic encephalopathy

This study tests whether treating enlarged stomach veins (gastric varices) early with a procedure called retrograde transvenous obliteration (RTO) can prevent dangerous bleeding. 68 adults with cirrhosis and gastric varices will be randomly assigned to either RTO or standard care…

This study looks at whether adding L-carnitine, a natural substance, to standard care can improve outcomes for critically ill adults with liver disease in the ICU. About 58 participants with conditions like liver failure or severe infections will be enrolled. Researchers will tra…

This study compares a new procedure using a special stent (underdilated VCX-TIPS) with standard treatment (endoscopic banding plus beta-blockers) to prevent variceal rebleeding in people with cirrhosis. The new approach uses a smaller balloon to expand the stent, aiming to lower …

This early-stage study tests a genetically-modified pig liver used outside the body to temporarily take over liver functions for people with acute-on-chronic liver failure. About 20 adults who are not eligible for a transplant will receive this treatment for a short time. The goa…

This study tests a new procedure that uses an endoscope (a thin tube with a camera) to guide coils and glue into abnormal blood vessels in the liver. The goal is to block these vessels and reduce severe confusion (hepatic encephalopathy) in people with liver cirrhosis. The trial …

This early study tests whether adding the steroid dexamethasone to standard hyperbaric oxygen therapy helps prevent long-term brain problems after carbon monoxide poisoning. Twenty adults who receive hyperbaric oxygen will be randomly given either dexamethasone or a placebo. Rese…

This study tests whether a fecal microbiota transplant (FMT) from healthy donors can prevent severe confusion (hepatic encephalopathy) in 40 patients who still get episodes despite standard drugs after a liver shunt procedure (TIPS). Participants receive either FMT or a placebo, …

This study tests whether a special 4D-flow MRI can accurately measure blood flow and pressure in the liver without needing an invasive catheter. Researchers will enroll 60 adults with cirrhosis and compare MRI results to the standard pressure test. If it works, this could make di…

This pilot study will test whether an iPad app called DCog Short can spot early signs of brain-related side effects (neurotoxicity) in 40 adults receiving CAR-T cell therapy for blood cancers. Participants will use the app to self-report symptoms, and researchers will compare the…

This study tests whether a personalized nutritional plan can prevent a serious brain condition called hepatic encephalopathy in people with liver cirrhosis who undergo a TIPS procedure. The trial will enroll 50 malnourished patients and compare the personalized diet to standard c…

This study tests whether capsules containing gut microbes from healthy people can prevent future episodes of hepatic encephalopathy (a brain condition caused by liver problems) in 162 veterans with cirrhosis. Participants will take the capsules and be monitored for hospital visit…

This study tests whether adding a bile acid pill (UDCA) to standard treatment can prevent a serious brain condition called hepatic encephalopathy after a liver procedure (TIPS). About 270 adults with cirrhosis will be randomly assigned to receive either UDCA plus lactulose or lac…

This study tests a home-based tele-rehabilitation program for people who have thinking and movement problems after chemotherapy. Sixty adults who finished chemo will be split into two groups: one gets 15 sessions of personalized cognitive and motor exercises via a tablet and remo…

This observational study will follow 30 multiple myeloma patients receiving a standard CAR-T therapy called cilta-cel. Researchers will collect blood, bone marrow, and other samples to find biomarkers linked to rare toxicities like nerve damage, blood issues, and gut problems. Th…

This study looks at hepatic encephalopathy, a brain complication from liver cirrhosis that can cause memory loss and confusion. Researchers will follow over 700 liver cirrhosis patients and 120 healthy volunteers in China for up to 3 years. Participants use a simple phone app to …

This study looks at a thinking and coordination test called PHES to find early, hidden brain problems in people with stable liver cirrhosis. About 150 patients and some healthy volunteers will take the test. The goal is to see how well the test catches these issues before they ge…

This study looks at differences in proteins and gut bacteria between liver cirrhosis patients with and without hepatic encephalopathy (a brain complication). Researchers will analyze blood and stool samples from 32 adults to find unique patterns that could help diagnose and under…