Spondylolisthesis

This study looks at whether placing a small drain near the surgical site after one- or two-level lumbar spine surgery reduces complications like infection or the need for another operation. About 975 adults having open back surgery for spinal stenosis or spondylolisthesis are ran…

This study tests whether carbon fiber screws work as well as titanium ones for spinal fusion in people with degenerative disc disease. Carbon fiber allows clearer MRI and CT scans after surgery, which may help doctors monitor healing better. About 118 adults needing one or two le…

This study looks at how well a spine implant (VIPER PRIME/Expedium) combined with a special bone graft putty (Fibergraft BG) helps bones fuse together after spine surgery. About 100 adults with spine problems like slipped vertebrae or disc degeneration will be followed for two ye…

This study is testing a device called the Minuteman G5 Fusion Plate, which is already approved for use, to see how well it helps people with chronic low back pain caused by degenerative spine conditions. About 150 adults who are candidates for this surgery will be followed for a …

This study is testing whether a special bone scan (SPECT/CT) can predict which patients with chronic back pain will have good results from lumbar fusion surgery. Researchers will measure how much the scan lights up in the spine and compare it to pain and disability scores one yea…

This study is testing whether artificial intelligence can accurately diagnose spinal deformities like scoliosis by analyzing photos of a person's bare back. Researchers will enroll 2,500 participants with various spinal conditions and compare the AI's assessment to standard X-ray…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests a new, smaller surgical tool called LUSE-TLIF against the current standard minimally invasive fusion (MIS-TLIF) for people with lumbar spinal stenosis. The new tool is a flexible endoscope only 1.8 mm wide, designed to give surgeons a better view and reduce muscl…

This study compares two techniques used during lumbar fusion surgery to see which one better reduces bleeding and pain after the operation. About 62 adults having back fusion surgery will be randomly assigned to receive either a large-volume injection of numbing medicine with a v…

This study looks at whether avoiding opioids during back surgery can still control pain and reduce side effects like nausea and constipation. About 75 adults having elective lumbar spine surgery will be placed into one of three groups based on their anesthesia plan. The goal is t…

This study tests whether taking melatonin, a natural sleep aid, can help teens aged 12-18 sleep better and recover faster after major musculoskeletal surgery (like scoliosis or hip surgery). About 45 teens will receive either a fast-dissolve melatonin pill or a placebo daily. The…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study compares two types of spine surgery for a condition called degenerative lumbar spondylolisthesis, where a vertebra slips forward and causes pain or nerve problems. One surgery uses a small camera (endoscope) to relieve pressure, while the other involves fusing bones to…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This early-stage trial is testing whether a new device called Regenn® Negative Pressure Therapy System is safe for people recovering from spinal fusion surgery. The device applies gentle suction to the surgical wound to help manage healing. About 30 adults will be randomly assign…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study is tracking 561 people who have already had spine surgery using METROSAN spinal implants and BONEGRAFT bone fillers. Researchers want to see how well these devices work and if any new safety issues pop up over a year. It's an observational study, meaning patients get s…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study is building a database of information from 300 adults who have had spine surgery using a special device called the Implanet Jazz System. The goal is to collect measurements like pain levels and quality of life to help doctors learn more and improve future treatments. P…