Sleep-wake disorder
MONDO:0003406Abnormal sleep-wake schedule or pattern associated with the circadian rhythm which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle. These can include dyssomnias such as circadian rhythm disorders, hypersomnia, and sleep apnea and parasomnias such as bruxism and rapid eye movement sleep disorder.
Also known as: disorder of sleep-wake cycle, sleep wake disorder, Subwakefullness syndrome, Subwakefullness syndromes, Tachypneas, sleep-related neurogenic, disorder of sleep-wake schedule, disorder, sleep, disorder, sleep wake
1063 clinical trials for this condition and its sub-types, 179 tagged with Sleep-wake disorder itself.
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Sub-types of Sleep-wake disorder
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Sleep apnea syndrome 214 trials · 603 incl. sub-types
2 sub-types
- Obstructive sleep apnea syndrome 519 trials · 520 incl. sub-types Sub-types →
- Central sleep apnea syndrome 21 trials · 23 incl. sub-types Sub-types →
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Circadian rhythm sleep disorder 103 trials · 138 incl. sub-types
8 sub-types
- Circadian rhythm sleep disorder, shift work type 35 trials
- Circadian rhythm sleep disorder, delayed sleep phase type 12 trials
- Rapid eye movement sleep disorder 4 trials
- Circadian rhythm sleep disorder, irregular sleep wake type 3 trials
- Circadian rhythm sleep disorder, jet lag type 2 trials
- Non-24-hour sleep-wake syndrome 2 trials
- Circadian rhythm sleep disorder, advanced sleep phase type 1 trial
- Advanced sleep phase syndrome 0 trials Sub-types →
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Narcolepsy 38 trials · 57 incl. sub-types
3 sub-types
- Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types Sub-types →
- Narcolepsy without cataplexy 22 trials
- Hereditary narcolepsy 0 trials · 5 incl. sub-types Sub-types →
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Bruxism 56 trials
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Hypersomnia 24 trials · 50 incl. sub-types
1 sub-type
- Idiopathic hypersomnia 28 trials Sub-types →
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REM sleep behavior disorder 48 trials
1 sub-type
- Rapid eye movement sleep disorder 4 trials
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Periodic limb movement disorder 2 trials
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Recurrent hypersomnia 0 trials
1 sub-type
- Kleine-Levin syndrome 0 trials
Most studied deeper sub-types
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Fixing sleep, fortifying hearts: a new trial tests the link
Disease control By invitation onlyThis trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…
Sponsor: Indiana University • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Could your mattress detect sleep apnea?
Diagnosis OngoingThis study tests whether a non-contact device placed under the mattress can accurately detect sleep apnea. Researchers will compare the device's readings to standard sleep tests in 200 adults suspected of having sleep apnea. If proven reliable, this could offer a simple, low-cost…
Sponsor: Withings • Aim: Diagnosis
Last updated Jun 27, 2026 09:05 UTC
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Could your blanket track your sleep? smart duvet tested in sleep lab
Diagnosis OngoingThis study tests a new 'intelligent duvet' called Easy Sleep Monitoring (ESM) that uses built-in sensors to detect movement and estimate sleep. Researchers will compare its accuracy to standard sleep lab tests (video-polysomnography) in 50 people, including those with sleep disor…
Sponsor: University Hospital, Clermont-Ferrand • Aim: Diagnosis
Last updated Jun 27, 2026 07:52 UTC
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Writing as medicine: can words soothe chronic pain?
Symptom relief CancelledThis study looks at whether a guided therapeutic writing program can help adult women with chronic pain and co-occurring mental health conditions. Participants will complete writing exercises focused on emotional processing and meaning-making over four weeks, then share their exp…
Sponsor: Toni Salikka • Aim: Symptom relief
Last updated Sep 04, 2026 00:00 UTC
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Can better sleep ease knee pain? new study tests sleep therapy for osteoarthritis
Symptom relief OngoingThis study looks at whether adding cognitive behavioral therapy for insomnia (CBT-I) to standard knee osteoarthritis care (education and exercise) helps reduce pain and improve function. About 128 adults aged 45+ with both knee osteoarthritis and insomnia will be followed for 6 m…
Sponsor: Vrije Universiteit Brussel • Aim: Symptom relief
Last updated Aug 22, 2026 00:00 UTC
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Sleep better, age better? study tests urolithin a and fisetin
Symptom relief OngoingThis study is testing whether two dietary supplements, urolithin A and fisetin, can improve sleep quality and reduce signs of aging in middle-aged and older adults. Eighty participants aged 30-75 with poor sleep will take one of the supplements, a combination, or a placebo daily …
Sponsor: Huazhong University of Science and Technology • Aim: Symptom relief
Last updated Aug 12, 2026 00:00 UTC
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Smart earbuds that listen to your heart could lull you to sleep
Symptom relief OngoingThis trial tests a pair of smart earbuds that use artificial intelligence to adjust soothing music in real time based on your heart rate and movement, aiming to help people with chronic insomnia fall asleep faster and sleep deeper. Adults with chronic insomnia will spend three ni…
Sponsor: The Chinese University of Hong Kong, Shenzhen • Aim: Symptom relief
Last updated Aug 06, 2026 00:00 UTC
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Could a new pill fix your body clock? phase 3 trial underway
Symptom relief OngoingThis Phase 3 trial tests whether the drug tasimelteon can help people with Delayed Sleep-Wake Phase Disorder (DSWPD) fall asleep earlier and sleep better. 70 adults with DSWPD will receive either tasimelteon or a placebo daily. The study measures sleep onset and quality using sle…
Phase 3 • Sponsor: Vanda Pharmaceuticals • Aim: Symptom relief
Last updated Jul 29, 2026 00:00 UTC
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Can sleep coaching help firefighters get better rest?
Symptom relief By invitation onlyThis study tests whether a sleep health coaching program, based on cognitive behavioral therapy for insomnia, can improve sleep in firefighters who have trouble sleeping. About 400 firefighters from 20 fire agencies in Arizona will take part. Half will receive the coaching progra…
Phase 4 • Sponsor: University of Arizona • Aim: Symptom relief
Last updated Jul 18, 2026 00:00 UTC
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Holy Qur'an or music: which helps kids on chemo sleep better?
Symptom relief OngoingThis study compares listening to Holy Qur'an recitation versus calming music before bed in children aged 6 to 10 who are undergoing chemotherapy. Sleep problems are common in these children, and the goal is to find a safe, non-medication way to improve sleep quality. Ninety child…
Sponsor: Rawand Shafeeq Ali • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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New combo therapy aims to beat Cancer-Related insomnia
Symptom relief OngoingThis phase 2 trial tests whether combining cognitive behavioral therapy, a stimulant (methylphenidate), melatonin, and light therapy can improve sleep in cancer patients. About 68 patients currently on cancer treatment who have sleep problems will participate. The study measures …
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Breathing your way to better sleep: new study targets Emotion-Linked insomnia
Symptom relief OngoingThis study tests whether a breathing training program can improve sleep in people whose insomnia is linked to anxiety or depression. Researchers will monitor sleep quality and heart activity in 188 adults. The goal is to find a simple, drug-free way to ease sleep problems and und…
Sponsor: Qilu Hospital of Shandong University • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Could a simple ear device ease Parkinson's symptoms?
Symptom relief By invitation onlyThis study tests a non-invasive device that stimulates a nerve in the ear to see if it can improve movement, mood, sleep, and motivation in people with Parkinson's disease. Thirty participants will try three different stimulation patterns over several weeks. The goal is to find t…
Sponsor: Anhui Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Brain chemical dopamine linked to sleep apnea risk in new study
Knowledge-focused By invitation onlyThis study looks at whether dopamine levels and certain genes affect the risk and severity of sleep breathing disorders like sleep apnea. Researchers will monitor 100 adults overnight and take blood samples to measure dopamine and check for genetic variations. The goal is to bett…
Sponsor: Wroclaw Medical University • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Why do people grind their teeth at night? new study seeks answers
Knowledge-focused By invitation onlyThis study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…
Sponsor: Wroclaw Medical University • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC
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AI and wearables join forces to uncover Dementia's hidden clues
Knowledge-focused OngoingThis study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…
Sponsor: IRCCS San Raffaele Roma • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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War wounds may trigger hidden heart risks, new study reveals
Knowledge-focused By invitation onlyThis study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…
Sponsor: Uniformed Services University of the Health Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Scientists probe the Mind-Sleep connection with brain and heart scans
Knowledge-focused By invitation onlyThis study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…
Sponsor: Qilu Hospital of Shandong University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Could a common drug stop teeth grinding and protect your heart?
Knowledge-focused By invitation onlyThis study examines the links between sleep bruxism (teeth grinding during sleep) and sleep quality, heart health, thyroid function, and mood. Researchers will give some participants opipramol, a drug that may reduce grinding activity, and monitor them with sleep tests. The goal …
Sponsor: Wroclaw Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Sleep study tracks hidden health risks for decades
Knowledge-focused OngoingThis study follows 1,545 adults over many years to understand how sleep-disordered breathing and other sleep problems develop and affect health. Participants were Wisconsin state employees aged 30-60 when the study began. Researchers use overnight sleep tests, questionnaires, and…
Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
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Can a watch reveal hidden sleep troubles in POTS patients?
Knowledge-focused OngoingThis study uses a wrist-worn activity watch to measure sleep quality in people with orthostatic intolerance (a condition where standing causes dizziness) compared to healthy volunteers. Researchers want to see if these patients have worse sleep, like taking longer to fall asleep.…
Sponsor: Satish R. Raj • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC